Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Takehiko Yasuji"'
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 103:95-103
Background Precipitation of poorly soluble, weakly basic drugs upon entering the small intestine may lead to poor bioavailability. It would be useful to be able to predict the extent of in vivo precipitation so that formulation measures to counteract
Autor:
Takehiko Yasuji, Keiichi Yoshihara, Kazuhiro Sako, Yuuki Kasashima, Noriyuki Namiki, Shinya Uchida
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1304-1309
The objective of this study was to establish the key factor of the lauryl sulfate (LS) salt/complex for sustained release of a hydrophilic drug at various physiological pH levels. Mirabegron is a hydrophilic drug that exhibits pH-dependent solubility
Autor:
Yuuki Kasashima, Takehiko Yasuji, Shinya Uchida, Kazuhiro Sako, Keiichi Yoshihara, Noriyuki Namiki
Publikováno v:
International journal of pharmaceutics. 515(1-2)
The objective of this study was to evaluate the feasibility of lauryl sulfate (LS) salt/complex as a novel carrier in oral sustained-release suspensions. Mirabegron, which has a pH-dependent solubility, was selected as the model drug. Sodium lauryl s
Publikováno v:
Therapeutic Delivery. 3:81-90
Here we review the mediation of the food effects on drugs by pharmaceutical technologies. The pharmacokinetics of drugs are affected by the interaction of drugs with food, which changes drug physicochemical and physiological properties (food effects)
Publikováno v:
Pharmaceutical Research. 17:94-99
Purpose. The properties of novel spray-dried lactose compositeparticles suitable for the coating filler of a dry-coated tablet having a longinduction period in drug release were investigated.
Publikováno v:
Pharmaceutical Research. 16:1193-1198
Purpose. Composite particles of lactose with a small amount of sodium alginate were prepared by spray-drying (SD) in an effort to improve the compactibility of the polymer for direct compression. The compaction behavior of the SD composite particles
Publikováno v:
International Journal of Pharmaceutics. 174:91-100
A novel composite particle suitable for the filler of controlled-release matrix tablets was prepared by spray-drying an aqueous solution of α -lactose monohydrate and sodium alginate. The spray-dried (SD) particles had an excellent flowing property
Publikováno v:
Advanced drug delivery reviews. 60(3)
In order to improve the dissolution properties of poorly water-soluble drugs, some drugs were subjected to micronization or prepared as composite particles using supercritical fluid (SCF) technology with carbon dioxide (CO(2)). Solubility in CO(2) is
Publikováno v:
Pharmaceutical development and technology. 5(3)
The purpose of this study was to investigate the temperature- and moisture-induced crystallization of amorphous lactose in the composite particles prepared by spray-drying an aqueous solution of crystalline lactose and sodium alginate. The temperatur
Publikováno v:
Chemicalpharmaceutical bulletin. 48(4)
The purpose of this study was to investigate the temperature-induced crystallization and the compactibility of the composite particles containing amorphous lactose and various types of polymers. The composite particles were prepared by spray-drying a