Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Takehiko Fujino"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Plasmalogens (Pls) are specialized phospholipids integral to brain health, whose decline due to aging and stress contributes to cognitive impairment and neuroinflammation. This study explores the potential of a novel Pls derivative, KIT-13 (1-O-octad
Externí odkaz:
https://doaj.org/article/cfc8d57de65141d2afa93b09ef58e01a
Autor:
Yu Wu, Borislav Angelov, Yuru Deng, Takehiko Fujino, Md Shamim Hossain, Markus Drechsler, Angelina Angelova
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Cyclic-AMP-response element-binding protein (CREB) is a leucine zipper class transcription factor that is activated through phosphorylation. Ample CREB phosphorylation is required for neurotrophin expression, which is of key importance for p
Externí odkaz:
https://doaj.org/article/33017c9842b541c7b428e29307969fae
Autor:
Hiroya Kadokawa, Miyako Kotaniguchi, Shiro Mawatari, Risa Saito, Takehiko Fujino, Shinichi Kitamura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Brain ethanolamine plasmalogens (EPls) are the only known ligands of G-protein-coupled receptor 61, a novel receptor that stimulates follicle-stimulating hormone (FSH), but not luteinizing hormone (LH), secretion by bovine gonadotrophs. We h
Externí odkaz:
https://doaj.org/article/18b59587ee2e497bbdd9b54789cc0f77
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Ethanolamine-containing alkenyl ether glycerophospholipids, plasmalogens, are major cell membrane components of mammalian cells that activate membrane protein receptors such as ion transporters and G-protein coupled receptors. However, the mechanism
Externí odkaz:
https://doaj.org/article/adcc572234f9468c9c93469fe8923ff3
Autor:
Minoru Fujino, Jun Fukuda, Hirohisa Isogai, Tetsuro Ogaki, Shiro Mawatari, Atsushi Takaki, Chikako Wakana, Takehiko Fujino
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Background: Plasmalogens have been shown to improve neurodegenerative pathology and cognitive function. We hypothesized that plasmalogens work in small amounts as a kind of hormone interacting with a G protein-coupled receptor, and then explored the
Externí odkaz:
https://doaj.org/article/466db1d00d6c4b299847159a7429288d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Plasmalogens (Pls), a kind of glycerophospholipids, have shown potent biological effects but their role in hippocampus-dependent memory remained mostly elusive. Here, we first report Pls can enhance endogenous expression of brain-derived neurotrophic
Externí odkaz:
https://doaj.org/article/ec84fdd3863145b3a100da14a886cb15
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Erythrocytes are oxygen carriers and exposed to redox cycle in oxygenation and deoxygenation of hemoglobin. This indicates that circulating erythrocytes are vulnerable to the oxidative injury occurring under the imbalance of redox homeostasis. In thi
Externí odkaz:
https://doaj.org/article/26fdfc711b714c67b6f16831fa744073
Autor:
Shiro Mawatari, Shinji Ohara, Yoshihide Taniwaki, Yoshio Tsuboi, Toru Maruyama, Takehiko Fujino
Publikováno v:
Parkinson's Disease, Vol 2020 (2020)
Introduction. Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). With the ageing of population, the frequency of PD is expected to increase dramatically in the coming decades. L-DOPA (1,3,
Externí odkaz:
https://doaj.org/article/c4ccefc367664599a4b9f6b1edd7d3dc
Publikováno v:
Practical Laboratory Medicine, Vol 10, Iss C, Pp 44-51 (2018)
Objectives: Ethanolamine ether phospholipids (ePE) and choline ether phospholipid (ePC) are present in human serum or plasma. Decreases in ether phospholipids (plasmalogens) in serum (plasma) have been reported in several diseases such as Alzheimer's
Externí odkaz:
https://doaj.org/article/47258ac22a0e45e29d1c92cf179fde3e
Autor:
Takehiko Fujino, Tatsuo Yamada, Takashi Asada, Yoshio Tsuboi, Chikako Wakana, Shiro Mawatari, Suminori Kono
Publikováno v:
EBioMedicine, Vol 17, Iss C, Pp 199-205 (2017)
Background: Plasmalogens (Pls) reportedly decreased in postmortem brain and in the blood of patients with Alzheimer's disease (AD). Recently we showed that intraperitoneal administration of Pls improved cognitive function in experimental animals. In
Externí odkaz:
https://doaj.org/article/b8ea21c2725f4006bfcc6ca85b440b38