Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Takehiko, Yokomizo"'
Autor:
Natsuki Ohkawa, Hiromichi Shoji, Naho Ikeda, Yayoi Murano, Toshiaki Okuno, Masato Kantake, Takehiko Yokomizo, Toshiaki Shimizu
Publikováno v:
Pediatrics and Neonatology, Vol 65, Iss 2, Pp 123-126 (2024)
Background: There is limited evidence on the association between the clinical course of patent ductus arteriosus (PDA) and prostaglandin (PG) metabolites. This study aimed to determine the influence of PDA treatment on urinary PG metabolite excretion
Externí odkaz:
https://doaj.org/article/146b288bbee440dcb3d3e1d7a7629b1a
Autor:
Airi Jo-Watanabe, Toshiki Inaba, Takahiro Osada, Ryota Hashimoto, Tomohiro Nishizawa, Toshiaki Okuno, Sayoko Ihara, Kazushige Touhara, Nobutaka Hattori, Masatsugu Oh-Hora, Osamu Nureki, Takehiko Yokomizo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Homoeostatic regulation of the acid–base balance is essential for cellular functional integrity. However, little is known about the molecular mechanism through which the acid–base balance regulates cellular responses. Here, we report tha
Externí odkaz:
https://doaj.org/article/f95ce9a7d6854817a73fa616defc04d5
Autor:
Hiroki Fujii, MD, Kazuko Saeki, PhD, Sujin Hoshi, MD, PhD, Yuri Kadoya, MD, Tetsuro Oshika, MD, PhD, Takehiko Yokomizo, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 2, Pp 100414- (2024)
Purpose: To establish a robust and objective method to evaluate (SPK) superficial punctate keratopathy in a murine dry eye model by developing a reliable photographic system. Design: Experimental study. Subjects: A murine dry eye model was generated
Externí odkaz:
https://doaj.org/article/8f3754cc61814f5cbf08cf914b419306
Autor:
Fumiya Takahashi, Takashi Baba, Antonius Christianto, Shogo Yanai, Hyeon-Cheol Lee-Okada, Keisuke Ishiwata, Kazuhiko Nakabayashi, Kenichiro Hata, Tomohiro Ishii, Tomonobu Hasegawa, Takehiko Yokomizo, Man Ho Choi, Ken-ichirou Morohashi
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113715- (2024)
Summary: The zona fasciculata (zF) in the adrenal cortex contributes to multiple physiological actions through glucocorticoid synthesis. The size, proliferation, and glucocorticoid synthesis characteristics are all female biased, and sexual dimorphis
Externí odkaz:
https://doaj.org/article/9961e1b280314f7cbbce9266e2036088
Autor:
Deepa Jonnalagadda, Yasuyuki Kihara, Aran Groves, Manisha Ray, Arjun Saha, Clayton Ellington, Hyeon-Cheol Lee-Okada, Tomomi Furihata, Takehiko Yokomizo, Edward V. Quadros, Richard Rivera, Jerold Chun
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113545- (2023)
Summary: Vitamin B12 (B12) deficiency causes neurological manifestations resembling multiple sclerosis (MS); however, a molecular explanation for the similarity is unknown. FTY720 (fingolimod) is a sphingosine 1-phosphate (S1P) receptor modulator and
Externí odkaz:
https://doaj.org/article/3f10e3549c7c42cb9615af7fb85c19b0
Autor:
Ryosuke Ishimura, Afnan H. El-Gowily, Daisuke Noshiro, Satoko Komatsu-Hirota, Yasuko Ono, Mayumi Shindo, Tomohisa Hatta, Manabu Abe, Takefumi Uemura, Hyeon-Cheol Lee-Okada, Tarek M. Mohamed, Takehiko Yokomizo, Takashi Ueno, Kenji Sakimura, Tohru Natsume, Hiroyuki Sorimachi, Toshifumi Inada, Satoshi Waguri, Nobuo N. Noda, Masaaki Komatsu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The UFM1 system, a ubiquitin-like conjugation system is crucial for endoplasmic reticulum (ER) homeostasis. Here, authors found that CYB5R3 is covalently conjugated with UFM1, which becomes a signal for ER-phagy, a selective autophagy of ER.
Externí odkaz:
https://doaj.org/article/fedd7858566a4c3695542e6f98801031
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Leydig cells highly express FADS2 to facilitate male steroid hormone production by accumulating omega-6 HUFA-containing cholesteryl esters, which serve as preferred substrates for hormone-sensitive lipase
Externí odkaz:
https://doaj.org/article/89678da2fbf446aa9c0ead2ba03be0d7
Autor:
Fumie Nakashima, Takashi Suzuki, Odaine N. Gordon, Dominic Golding, Toshiaki Okuno, Juan A. Giménez-Bastida, Takehiko Yokomizo, Claus Schneider
Publikováno v:
JACS Au, Vol 1, Iss 9, Pp 1380-1388 (2021)
Externí odkaz:
https://doaj.org/article/767303db875b4c539101de30ffc05318
Autor:
Bo Han, Hyeon‐Cheol Lee‐Okada, Momoko Ishimine, Hajime Orita, Keiko Nishikawa, Tetsuya Takagaki, Kazunori Kajino, Takehiko Yokomizo, Okio Hino, Toshiyuki Kobayashi
Publikováno v:
FEBS Open Bio, Vol 10, Iss 11, Pp 2375-2387 (2020)
Malignant mesothelioma (MM) is an aggressive malignant neoplasm which rapidly invades pleural tissues and has a poor prognosis. Here, we explore enhancement of the effect of irinotecan [camptothecin‐11 (CPT‐11)] by the p53‐dependent induction o
Externí odkaz:
https://doaj.org/article/95ef359e025a429ea89d075c8971ea0a
Autor:
Miho Asahara, Nobuko Ito, Yoko Hoshino, Takaharu Sasaki, Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu, Yoshitsugu Yamada
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Leukotriene B4 (LTB4) is a potent lipid mediator involved in the recruitment and activation of neutrophils, which is an important feature of tissue injury and inflammation. The biological effects of LTB4 are primarily mediated through the high-affini
Externí odkaz:
https://doaj.org/article/72a6cc41bfe149d28111edbfb2949b3d