Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Takehiko, Yokobori"'
Autor:
Kouki Hoshino, Seshiru Nakazawa, Takehiko Yokobori, Kei Hagiwara, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Kenichiro Araki, Norifumi Harimoto, Fuminori Tokunaga, Ken Shirabe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract RNF31 is a multifunctional RING finger protein implicated in various inflammatory diseases and cancers. It functions as a core component of the linear ubiquitin chain assembly complex (LUBAC), which activates the nuclear factor kappaB (NF-κ
Externí odkaz:
https://doaj.org/article/9025baf96e8442feb4c6e0ffaa86bfae
Autor:
Natsumi Mori, Gendensuren Dorjkhorloo, Takuya Shiraishi, Bilguun Erkhem-Ochir, Haruka Okami, Arisa Yamaguchi, Ikuma Shioi, Chika Komine, Mizuki Endo, Takaomi Seki, Nobuhiro Hosoi, Nobuhiro Nakazawa, Yuta Shibasaki, Takuhisa Okada, Katsuya Osone, Akihiko Sano, Makoto Sakai, Makoto Sohda, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki
Publikováno v:
Cancers, Vol 16, Iss 15, p 2684 (2024)
Tertiary lymphoid structures (TLSs) are complex lymphocyte clusters that arise in non-lymphoid tissues due to inflammation or cancer. A mature TLS with proliferating germinal centers is associated with a favorable prognosis in various cancers. Howeve
Externí odkaz:
https://doaj.org/article/c4d77d4d7aff4cc2a8da0bdc9908d5d0
Autor:
Nobuhiro Nakazawa, Makoto Sohda, Takehiko Yokobori, Navchaa Gombodorj, Akihiko Sano, Makoto Sakai, Tetsunari Oyama, Hiroyuki Kuwano, Ken Shirabe, Hiroshi Saeki
Publikováno v:
Annals of Gastroenterological Surgery, Vol 6, Iss 4, Pp 505-514 (2022)
Abstract Background Connexin is a basic molecule that forms gap junctions and undergoes localization changes to the cytoplasm in association with carcinogenesis. We aimed to investigate and clarify the significance of cytoplasmic Cx26 expression in g
Externí odkaz:
https://doaj.org/article/4208efdfc7e14caeb6b21e6825c534c7
Identification of MicroRNAs Associated with Histological Grade in Early-Stage Invasive Breast Cancer
Autor:
Sasagu Kurozumi, Naohiko Seki, Eriko Narusawa, Chikako Honda, Shoko Tokuda, Yuko Nakazawa, Takehiko Yokobori, Ayaka Katayama, Nigel P. Mongan, Emad A. Rakha, Tetsunari Oyama, Takaaki Fujii, Ken Shirabe, Jun Horiguchi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 35 (2023)
This study aimed to identify microRNAs associated with histological grade using comprehensive microRNA analysis data obtained by next-generation sequencing from early-stage invasive breast cancer. RNA-seq data from normal breast and breast cancer sam
Externí odkaz:
https://doaj.org/article/e65fda22e5d64172a45719880f053973
Autor:
Hiroyuki Kuwano, Takehiko Yokobori, Munenori Ide, Hiroshi Saeki, Makoto Sohda, Makoto Sakai, Tomonori Yoshida, Kengo Kuriyama, Kyoichi Ogata, Hiroomi Ogawa, Takuhisa Okada, Tatsuya Miyazaki, Shunsuke Takahashi, Ken Shirabe
Publikováno v:
Cancer Medicine, Vol 11, Iss 4, Pp 983-992 (2022)
Abstract Background & Aims Mixed neuroendocrine–non‐neuroendocrine neoplasm (MiNEN) is a rare neuroendocrine neoplasm (NEN) comprising dual neuroendocrine and non‐neuroendocrine components. Although the coexistence pattern of neuroendocrine and
Externí odkaz:
https://doaj.org/article/68a3afb7febe46d79730b9fe22797339
Autor:
Sasagu Kurozumi, Kyoichi Kaira, Hiroshi Matsumoto, Masafumi Kurosumi, Takehiko Yokobori, Yoshikatsu Kanai, Chikako Sekine, Chikako Honda, Ayaka Katayama, Mio Furuya, Sho Shiino, Takaya Makiguchi, Nigel P. Mongan, Emad A. Rakha, Tetsunari Oyama, Takaaki Fujii, Ken Shirabe, Jun Horiguchi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract L-type amino acid transporter 1 (LAT1), also referred to as SLC7A5, is believed to regulate tumor metabolism and be associated with tumor proliferation. In invasive breast cancer, we clinicopathologically investigated the utility of LAT1 exp
Externí odkaz:
https://doaj.org/article/4daa3a3afb8940298b1d057e671dbd12
Autor:
Kenjiro Ogushi, Takehiko Yokobori, Sumihito Nobusawa, Takahiro Shirakura, Junko Hirato, Bilguun Erkhem-Ochir, Haruka Okami, Gendensuren Dorjkhorloo, Akira Nishi, Makoto Suzuki, Sayaka Otake, Hiroshi Saeki, Ken Shirabe
Publikováno v:
Cancers, Vol 15, Iss 18, p 4482 (2023)
Background. Stathmin 1 (STMN1), a marker for immature neurons and tumors, controls microtubule dynamics by destabilizing tubulin. It plays an essential role in cancer progression and indicates poor prognosis in several cancers. This potential protein
Externí odkaz:
https://doaj.org/article/ece04e10cfbf4869940d9ef4682884cd
Autor:
Haruka Okami, Naoya Ozawa, Makoto Sohda, Takehiko Yokobori, Katsuya Osone, Bilguun Erkhem-Ochir, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Tatsuya Miyazaki, Hiroomi Ogawa, Takashi Yao, Takahiro Oike, Hiro Sato, Ken Shirabe, Atsushi Shibata, Hiroshi Saeki
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13648 (2023)
Human leukocyte antigen class I (HLA-I) is considered a genetic pathogen for ulcerative colitis (UC). This study aimed to investigate the significance of DNA damage and HLA-I expression in infiltrating immune cells and immune checkpoint protein PD-L1
Externí odkaz:
https://doaj.org/article/93c8d5ffedd545f096334e9c74868a24
Autor:
Nobuhiro Nakazawa, Takehiko Yokobori, Makoto Sohda, Nobuhiro Hosoi, Takayoshi Watanabe, Yuki Shimoda, Munenori Ide, Akihiko Sano, Makoto Sakai, Bilguun Erkhem-Ochir, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11790 (2023)
Lipopolysaccharides are a type of polysaccharide mainly present in the bacterial outer membrane of Gram-negative bacteria. Recent studies have revealed that lipopolysaccharides contribute to the immune response of the host by functioning as a cancer
Externí odkaz:
https://doaj.org/article/3240654976be4e80a7123e78802e2707
Autor:
Naoya Ozawa, Takehiko Yokobori, Katsuya Osone, Chika Katayama, Kunihiko Suga, Chika Komine, Yuta Shibasaki, Takuya Shiraishi, Takuhisa Okada, Ryuji Kato, Hiroomi Ogawa, Akihiko Sano, Makoto Sakai, Makoto Sohda, Hitoshi Ojima, Tatsuya Miyazaki, Yoko Motegi, Munenori Ide, Takashi Yao, Hiroyuki Kuwano, Ken Shirabe, Hiroshi Saeki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Ulcerative colitis (UC) is a DNA damage-associated chronic inflammatory disease; the DNA double-strand break (DSB) repair pathway participates in UC-associated dysplasia/colitic cancer carcinogenesis. The DSB/interferon regulatory factor-1 (
Externí odkaz:
https://doaj.org/article/af1b22a145e34167b4094d6666a0d50f