Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Takehiko, Ueyama"'
Autor:
Takashi Sasayama, Takeshi Hamada, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Takehiko Ueyama
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-11 (2024)
Abstract Glioblastoma is the most common malignant brain tumor in adults, the survival rate of which has not significantly improved over the past three decades. Therefore, there is an urgent need to develop novel treatment modalities. We previously r
Externí odkaz:
https://doaj.org/article/ea4f1c9feeab4ce5a84e6ab40539c443
Autor:
Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W. Kilimann, Takehiko Ueyama, Masahiko Watanabe, Tomomi Shimogori, Hideyuki Okano, Naoshi Dohmae, Toru Takumi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Postsynaptic proteins play crucial roles in synaptic function and plasticity. During brain development, alterations in synaptic number, shape, and stability occur, known as synapse maturation. However, the postsynaptic protein composition ch
Externí odkaz:
https://doaj.org/article/6f5fb2950d1a4074bc884f6b375b37fc
Publikováno v:
Neurobiology of Disease, Vol 186, Iss , Pp 106280- (2023)
Considerable evidence of reactive oxygen species (ROS) involvement in cochlear hair cell (HC) loss, leading to acquired sensorineural hearing loss (SNHL), were reported. Cochlear synaptopathy between HCs and spiral ganglion neurons has been gathering
Externí odkaz:
https://doaj.org/article/13ce5f34d3c84c8ba56e5d032842d681
Autor:
Haruki Hirakawa, Kei Taguchi, Seiya Murakawa, Masaya Asano, Soma Noguchi, Satoshi Kikkawa, Kana Harada, Naoko Adachi, Takehiko Ueyama, Izumi Hide, Shigeru Tanaka, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 187-195 (2022)
Flurbiprofen, a nonsteroidal anti-inflammatory drug, reportedly exhibits chemical chaperone activity. Herein, we investigated the role of flurbiprofen in regulating serotonin transporter (SERT) function via membrane trafficking. We used COS-7 cells t
Externí odkaz:
https://doaj.org/article/9330ce51e2554433b6a7217e7813e997
Autor:
Shigefumi Morioka, Hirofumi Sakaguchi, Hiroaki Mohri, Mariko Taniguchi-Ikeda, Motoi Kanagawa, Toshiaki Suzuki, Yuko Miyagoe-Suzuki, Tatsushi Toda, Naoaki Saito, Takehiko Ueyama
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008826 (2020)
Hearing loss (HL) is one of the most common sensory impairments and etiologically and genetically heterogeneous disorders in humans. Muscular dystrophies (MDs) are neuromuscular disorders characterized by progressive degeneration of skeletal muscle a
Externí odkaz:
https://doaj.org/article/e459f0bf0deb4f4bba4537cab949d556
Autor:
Takashi Nakamura, Hirofumi Sakaguchi, Hiroaki Mohri, Yuzuru Ninoyu, Akihiro Goto, Taro Yamaguchi, Yoshitaka Hishikawa, Michiyuki Matsuda, Naoaki Saito, Takehiko Ueyama
Publikováno v:
Journal of Molecular Medicine.
Abstract Rac small GTPases play important roles during embryonic development of the inner ear; however, little is known regarding their function in cochlear hair cells (HCs) after specification. Here, we revealed the localization and activation of Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f81b9b132b6fa4fa6c495a333b29b37
https://doi.org/10.1007/s00109-023-02317-4
https://doi.org/10.1007/s00109-023-02317-4
Autor:
Takehiko Ueyama, Yuzuru Ninoyu, Shin‐ya Nishio, Takushi Miyoshi, Hiroko Torii, Koji Nishimura, Kazuma Sugahara, Hideaki Sakata, Dean Thumkeo, Hirofumi Sakaguchi, Naoki Watanabe, Shin‐ichi Usami, Naoaki Saito, Shin‐ichiro Kitajiri
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 11, Pp 1310-1324 (2016)
Abstract DIAPH1 encodes human DIA1, a formin protein that elongates unbranched actin. The c.3634+1G>T DIAPH1 mutation causes autosomal dominant nonsyndromic sensorineural hearing loss, DFNA1, characterized by progressive deafness starting in childhoo
Externí odkaz:
https://doaj.org/article/8ba343c90b2e49b3816b0a1f746534e5
Autor:
Seiya Murakawa, Naoko Adachi, Takehiko Ueyama, Haruki Hirakawa, Kei Taguchi, Sohma Noguchi, Kana Harada, Norio Sakai, Masaya Asano, Izumi Hide, Shigeru Tanaka, Satoshi Kikkawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 187-195 (2022)
Flurbiprofen, a nonsteroidal anti-inflammatory drug, reportedly exhibits chemical chaperone activity. Herein, we investigated the role of flurbiprofen in regulating serotonin transporter (SERT) function via membrane trafficking. We used COS-7 cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23831ee8d956735081c839b73811d3c
http://www.sciencedirect.com/science/article/pii/S1347861321001134
http://www.sciencedirect.com/science/article/pii/S1347861321001134
Autor:
Loïc Maillard, Naoaki Saito, Hanna Hlawaty, Véronique Friand, Nadine Suffee, Fanny Chmilewsky, Oualid Haddad, Christelle Laguillier, Erwan Guyot, Takehiko Ueyama, Olivier Oudar, Angela Sutton, Nathalie Charnaux
Publikováno v:
Biology Open, Vol 3, Iss 10, Pp 995-1004 (2014)
The perpetuation of angiogenesis is involved in certain chronic inflammatory diseases. The accelerated neovascularisation may result from an inflammatory status with a response of both endothelial cells and monocytes to inflammatory mediators such as
Externí odkaz:
https://doaj.org/article/270ce84ec53548b88673fcc443cfd1b3
Autor:
Shigeru Hirano, Hiroaki Mohri, Hirofumi Sakaguchi, Yuzuru Ninoyu, Naoaki Saito, Takehiko Ueyama
Publikováno v:
The Journal of Neuroscience
Reactive oxygen species (ROS) produced by NADPH oxidases (Nox) contribute to the development of different types of sensorineural hearing loss (SNHL), a common impairment in humans with no established treatment. Although the essential role of Nox3 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229a062cf7cee3f3469f265fda6aa55a
https://hdl.handle.net/20.500.14094/90008398
https://hdl.handle.net/20.500.14094/90008398