Výsledky vyhledávání - "Takehiko, Matsumura"

Automated radiosynthesis of [11C]MTP38—a phosphodiesterase 7 imaging tracer—using [11C]hydrogen cyanide for clinical applications

Autor: Kazunori, Kawamura, Hiroki, Hashimoto, Ohkubo, Takayuki, Masayuki, Hanyu, Masanao, Ogawa, Nobuki, Nengaki, Daisuke, Arashi, Kurihara, Yusuke, Fujishiro, Tomoya, Togashi, Takahiro, Sakai, Toshiyuki, Masatoshi, Muto, Makoto, Takei, Hideki, Ishii, Takeaki, Saijo, Takehiko, Matsumura, Naoyuki, Obokata, Zhang, Ming-Rong

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 65(5):140-146

We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3- a]pyrazine-5-[11C]carbonitrile ([11C]MTP38) as a PET tracer for the imaging of phosphodiesterase 7. For the fully automated production of [11C]MTP38 routinely and efficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::888be5395770096a5a4614398f9dd947
https://repo.qst.go.jp/records/85665

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Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain

Autor: Takehiko Matsumura, Chie Seki, Makoto Higuchi, Ming-Rong Zhang, Misae Takakuwa, Takeaki Saijo, Hajime Fukuda, Jun Maeda, Naoyuki Obokata, Takeshi Hirata, Hideki Ishii, Takafumi Minamimoto, Tatsuo Nakajima, Kazunori Kawamura, Yuji Nagai

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging

Purpose Phosphodiesterase (PDE) 7 is a potential therapeutic target for neurological and inflammatory diseases, although in vivo visualization of PDE7 has not been successful. In this study, we aimed to develop [11C]MTP38 as a novel positron emission

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655bdffc9932ea6eab843c65edab30a3
https://doi.org/10.1007/s00259-021-05269-4

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Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain

Autor: Takeaki Saijo, Chie Seki, Ming-Rong Zhang, Jun Maeda, Takafumi Minamimoto, Takehiko Matsumura, Tatsuo Nakajima, Kazunori Kawamura, Yuji Nagai, Misae Takakuwa, Hajime Fukuda, Naoyuki Obokata, Takeshi Hirata, Hideki Ishii, Makoto Higuchi

PurposePhosphodiesterase (PDE) 7 is a potential therapeutic target for neurological and inflammatory diseases, although in-vivo visualization of PDE7 has not been successful. In this study, we aimed to develop [11C]MTP38 as a novel positron emission

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f79a4ac17c6a38052bff078dcdb122fb
https://doi.org/10.1101/2020.10.29.354696

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Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor

Autor: Kei Takedomi, Eiji Kawanishi, Yumi Watanabe, Mayumi Kimura, Koki Kojima, Yoichi Kadoh, Yoshihito Tanaka, Takehiko Matsumura, Kenji Omori, Tamaki Kobayashi, Toshiaki Sakamoto, Haruko Miyoshi, Jun Kotera, Toshiyuki Himiyama, Mitsuya Hongu, Takashi Sasaki, Hiroyuki Taniguchi

Publikováno v: Chemical and Pharmaceutical Bulletin. 66:243-250

Phosphodiesterase (PDE) 10A is a dual hydrolase of cAMP and cGMP and highly expressed in striatal medium spiny neurons. Inhibition of PDE10A modulates the activity of medium spiny neurons (MSN) via the regulation of cAMP and cGMP. Signal control of M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6843e881235274aefe3a3c26a35ba5a
https://doi.org/10.1248/cpb.c17-00783

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Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety

Autor: Takehiko Matsumura, Hiroyuki Taniguchi, Takashi Sasaki, Misae Takakuwa, Haruko Miyoshi, Yoichi Kadoh, Eiji Kawanishi, Mitsuya Hongu, Yoshihito Tanaka, Yumi Watanabe, Kei Takedomi, Nobuyuki Baba, Yuuki Koizumi, Jun Kotera, Koki Kojima, Itsuko Nakamura

Publikováno v: Bioorganicmedicinal chemistry. 27(15)

We have developed a new class of PDE10A inhibitor, a pyrazolo[1,5-a]pyrimidine derivative MT-3014 (1). A previous compound introduced was deprioritized due to concerns for E/Z-isomerization and glutathione-adduct formation at the core stilbene struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd08f7ec18e9eee0e29fcebbf425ca7
https://pubmed.ncbi.nlm.nih.gov/31235264

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Direct reductive amination using triethylsilane and catalytic bismuth(III) chloride

Autor: Masahisa Nakada, Takehiko Matsumura

Publikováno v: Tetrahedron Letters. 55:1829-1834

Direct reductive amination (DRA) using triethylsilane (TESH) and catalytic bismuth(III) chloride (BiCl 3 ) is described for the first time. The use of TESH and BiCl 3 provides easy handling, low cost, non-toxicity, and a mild Lewis acid activity, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53ad68c756e1e94e8f967b3eaa4a712c
https://doi.org/10.1016/j.tetlet.2014.01.132

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Preparation of imidazolinium salts by the Pd-catalyzed reduction of thioureas with triethylsilane and trialkylsilyl triflate

Autor: Takehiko Matsumura, Masahisa Nakada

Publikováno v: Tetrahedron Letters. 55:1412-1415

A Pd-catalyzed method for the preparation of imidazolinium salts from the corresponding thioureas that could then be used for the synthesis of imidazolium and amidinium salts is described. This method has great potential because all the required reag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df12e5a81ae2ab7761b9a9686c8ac390
https://doi.org/10.1016/j.tetlet.2014.01.022

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