Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Takeharu Tonai"'
Autor:
Naoki Shinohara, Toru Uyama, Xing-Hua Jin, Kazuhito Tsuboi, Takeharu Tonai, Hitoshi Houchi, Natsuo Ueda
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 1927-1935 (2011)
A-C1 protein is the product of a tumor suppressor gene negatively regulating the oncogene Ras and belongs to the HRASLS (HRAS-like suppressor) subfamily. We recently found that four members of this subfamily expressed in human tissues function as pho
Externí odkaz:
https://doaj.org/article/33bda5f6a95d4431bc15be35a88e62ac
Autor:
E. Kudo-Tanaka, Koichiro Saisho, Atsushi Ogata, S. Teshigawara, Noriyuki Chiba, Takuro Nii, S. Tsuji, Y. Harada, Hideki Tsuboi, Makoto Sueishi, Takeharu Tonai, Akiko Yura, Akane Watanabe, Masato Matsushita, Jun Hashimoto, Shiro Ohshima, Yasuo Suenaga, M. Yoshimura, Makoto Hirao, Yukihiko Saeki, Takashi Shimizu, Shigeto Tohma
Publikováno v:
Modern Rheumatology. 25:831-836
To examine whether or not earlier therapeutic intervention with methotrexate (MTX) prevents the development of rheumatoid arthritis (RA) in patients with recent-onset undifferentiated arthritis (UA) showing high anti-citrullinated peptide antibody (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46312e1b7815b648f3eab10c1982f289
https://doi.org/10.3109/14397595.2015.1031364
https://doi.org/10.3109/14397595.2015.1031364
Autor:
Kiyoshi Migita, Shigeki Miyata, Tomotaro Sato, Seiji Bito, Shigeru Yamada, Motoyuki Shimizu, Kazuo Ikeda, Shinnosuke Nakahara, Satoru Motokawa, Toshihito Mori, Kazuhito Shinohara, Masataka Kamei, Shusuke Ota, Mashio Nakamura, Yasuhiro Shibata, Chikara Kubota, Naofumi Shiota, Kazuhiko Kishi, Takeharu Tonai, Takeshi Minamizaki
Platelet-activating antibodies, which recognize platelet factor 4 (PF4)/heparin complexes, induce spontaneous heparin-induced thrombocytopenia (HIT) syndrome or fondaparinux-associated HIT without exposure to unfractionated heparin (UFH) or low-molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26a9ac8077ef777a8e4c8faaedd9e52
https://europepmc.org/articles/PMC4768427/
https://europepmc.org/articles/PMC4768427/
Autor:
Takeharu Tonai, Kazuhito Tsuboi, Akira Tokumura, Naoki Shinohara, Xing-Hua Jin, Toru Uyama, Natsuki Ikematsu, Natsuo Ueda, Manami Inoue
Publikováno v:
Journal of Biological Chemistry. 287:31905-31919
Bioactive N-acylethanolamines (NAEs), including N-palmitoylethanolamine, N-oleoylethanolamine, and N-arachidonoylethanolamine (anandamide), are formed from membrane glycerophospholipids in animal tissues. The pathway is initiated by N-acylation of ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7458d19d82f119e751809260c1be38ac
https://doi.org/10.1074/jbc.m112.368712
https://doi.org/10.1074/jbc.m112.368712
Autor:
Hitoshi Houchi, Naoki Shinohara, Xing-Hua Jin, Natsuo Ueda, Kazuhito Tsuboi, Toru Uyama, Takeharu Tonai
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 1927-1935 (2011)
A-C1 protein is the product of a tumor suppressor gene negatively regulating the oncogene Ras and belongs to the HRASLS (HRAS-like suppressor) subfamily. We recently found that four members of this subfamily expressed in human tissues function as pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5f1685c2cf06d73c5def9a99a3c23c
https://doi.org/10.1194/jlr.m015081
https://doi.org/10.1194/jlr.m015081
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1791:32-38
The formation of N-acylphosphatidylethanolamine by N-acylation of phosphatidylethanolamine (PE) is the initial step in the biosynthetic pathway of bioactive N-acylethanolamines, including the endocannabinoid anandamide and the anti-inflammatory subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5eee5d842b5271e934dfdd05842d821
https://doi.org/10.1016/j.bbalip.2008.09.006
https://doi.org/10.1016/j.bbalip.2008.09.006
Autor:
Takeharu Tonai, Makoto Murakami, Yong-Xin Sun, Kazuhito Tsuboi, Yasuo Okamoto, Natsuo Ueda, Ichiro Kudo
Publikováno v:
Biochemical Journal. 380:749-756
Anandamide (an endocannabinoid) and other bioactive long-chain NAEs (N-acylethanolamines) are formed by direct release from N-acyl-PE (N-acyl-phosphatidylethanolamine) by a PLD (phospholipase D). However, the possible presence of a two-step pathway f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b06a86cdeaa748a07ebe703ffd8b545
https://doi.org/10.1042/bj20040031
https://doi.org/10.1042/bj20040031
Publikováno v:
Journal of Biological Chemistry. 279:5298-5305
Anandamide (N-arachidonoylethanolamine) is known to be an endogenous ligand of cannabinoid and vanilloid receptors. Its congeners (collectively referred to as N-acylethanolamines) also show a variety of biological activities. These compounds are prin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5710418011702b241295d54aaab1ba
https://doi.org/10.1074/jbc.m306642200
https://doi.org/10.1074/jbc.m306642200
Autor:
Takehiko Nishisho, Kei-ichiro Shiba, Masahiro Muraguchi, Hiroyuki Ohsaki, Takeharu Tonai, Yasukazu Ohmoto, Eiji Takeda, Kaori Murata, Yutaka Taketani
Publikováno v:
Journal of Neurochemistry. 78:1064-1072
In view of a cytoprotective effect of elastase inhibitor on chemokine-mediated tissue injury, we examined the neuroprotective effect of ONO-5046, a specific inhibitor of neutrophil elastase, in rats with spinal cord injury. Standardized spinal cord c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae48a88fbe33f0c1950adafca307d2f2
https://doi.org/10.1046/j.1471-4159.2001.00488.x
https://doi.org/10.1046/j.1471-4159.2001.00488.x
Publikováno v:
Orthopedics & Traumatology. 41:528-531
Metastatic bone tumors were treated by reimplantation of the resected bone after autoclaving, with filling of the defects caused by tumor resection using fresh autogenous bone grafts.Case 1. A 67-year-old woman with lung cancer had a lytic lesion in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a1a9adea5f498ceba3e3e84d1e8349
https://doi.org/10.5035/nishiseisai.41.528
https://doi.org/10.5035/nishiseisai.41.528