Highly Water-Soluble Orotic Acid Nanocrystals Produced by High-Energy Milling

Autor: Nikoletta Fotaki, Gabriel Lima Barros de Araujo, Raimar Löbenberg, Veni Maria Andres Felli, Jéssica de Cássia Zaghi Compri, Takayuki Takatsuka, Nadia Araci Bou-Chacra, Felipe Rebello Lourenço

Publikováno v: de Cássia Zaghi Compri, J, Andres Felli, V M, Lourenço, F R, Takatsuka, T, Fotaki, N, Löbenberg, R, Bou-Chacra, N A & Barros de Araujo, G L 2019, ' Highly Water-Soluble Orotic Acid Nanocrystals Produced by High-Energy Milling ', Journal of Pharmaceutical Sciences, vol. 108, no. 5, pp. 1848-1856 . https://doi.org/10.1016/j.xphs.2018.12.015

Orotic acid (OA), a heterocyclic compound also known as vitamin B13, has shown potent antimalarial and cardiac protection activities; however, its limited water solubility has posed a barrier to its use in therapeutic approaches. Aiming to overcome t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135a293e02de3d13beb467258fb76815
https://pubmed.ncbi.nlm.nih.gov/30599168

Nanosizing of Poorly Water Soluble Compounds Using Rotation/Revolution Mixer

Autor: Naofumi Hashimoto, Yao Jianguo, Kayo Yuminoki, Takayuki Takatsuka, Tomoko Endo

Publikováno v: Chemical and Pharmaceutical Bulletin. 57:1061-1067

In this study, nanoparticles of various poorly water soluble compounds were prepared by wet milling that was carried out using a rotation/revolution mixer and zirconia balls. To be compared with Beads mill, rotation/revolution mixer has superior in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682670a0e038988c9a96fa81b9235e8b
https://doi.org/10.1248/cpb.57.1061