Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Takayoshi Kuno"'
Identification and characterization of a novel antifungal compound tubeimoside I targeting cell wall
Autor:
Qiannan Liu, Zhiqi Zhong, Shunxin Zheng, Yunzhuo Chu, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Due to fungal diseases that threaten immunocompromised patients, along with the limited availability of antifungal agents, there is an urgent need for new antifungal compounds to treat fungal infections. Here, we aimed to identify potential
Externí odkaz:
https://doaj.org/article/63b07fc2fa0243e7a1310747315fecd0
Autor:
Yingrong Shi, Si Chen, Huijuan Xing, Guanglie Jiang, Nan Wu, Qiannan Liu, Norihiro Sakamoto, Takayoshi Kuno, Reiko Sugiura, Qinghuan Xiao, Feng Jin, Yue Fang, Fan Yao
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Recent studies reveal that tumor microenvironment contributes to breast cancer (BRCA) development, progression, and therapeutic response. However, the contribution of the tumor microenvironment-related genes in routine diagnostic testing or therapeut
Externí odkaz:
https://doaj.org/article/f97b771b014b49e3a057feedda777f5e
Autor:
Kun Liu, Qiannan Liu, Yanli Sun, Jinwei Fan, Yu Zhang, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang
Publikováno v:
Frontiers in Microbiology, Vol 12 (2022)
Aberration in the control of cell cycle contributes to the development and progression of many diseases including cancers. Ksg1 is a Schizosaccharomyces pombe fission yeast homolog of mammalian phosphoinositide-dependent protein kinase 1 (PDK1) which
Externí odkaz:
https://doaj.org/article/5f3634d3e18e45b3998bc64a83ae2cce
Autor:
Hao Miao, Qiannan Liu, Guanglie Jiang, Wen Zhang, Kun Liu, Xiang Gao, Yujie Huo, Si Chen, Toshiaki Kato, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228845 (2020)
Sterol regulatory element-binding protein (SREBP), a highly conserved family of membrane-bound transcription factors, is an essential regulator for cellular cholesterol and lipid homeostasis in mammalian cells. Sre1, the homolog of SREBP in the fissi
Externí odkaz:
https://doaj.org/article/d4d047dd70e54a2887ec3496826d2742
Autor:
Yikun Yang, Qiannan Liu, Guanglie Jiang, Si Chen, Lina Zhou, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang, Fan Yao
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198516 (2018)
To study sodium homeostasis, we performed a genome-wide screen for deletion strains that show resistance to NaCl. We identified 34 NaCl-resistant strains. Among them, the largest group that consists of 10 genes related to membrane trafficking and 7 o
Externí odkaz:
https://doaj.org/article/7e267cd594524b5bb1533e607facb2e5
Autor:
Kun Liu, Guanglie Jiang, Hao Miao, Toshiaki Kato, Qiannan Liu, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang, Xiang Gao, Si Chen
Publikováno v:
Molecular Microbiology. 115:1323-1338
Mitochondria play essential roles in eukaryotic cells for glucose metabolism to produce ATP. In Schizosaccharomyces pombe, transcription factor Rst2 can be activated upon glucose deprivation. However, the link between Rst2 and mitochondrial function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dbebb30d11ab0d9127161ed31ce8731
https://doi.org/10.1111/mmi.14678
https://doi.org/10.1111/mmi.14678
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 2, Pp 273-283 (2005)
We have investigated the toxicity of an α1L-adrenoceptor agonist, ESR 1150 CL, and compared the toxicokinetics and pharmacokinetics in rats and monkeys. In rats, this compound induced death with remarkable sacculated aneurysms of the aorta in groups
Externí odkaz:
https://doaj.org/article/3a66c0c7d66f4cfe92b284422fa6765e
Autor:
Yue Fang, Wurentuya Jaiseng, Yan Ma, Lingling Hu, Shizuka Yamazaki, Xibo Zhang, Tsutomu Hayafuji, Lin Shi, Takayoshi Kuno
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85238 (2014)
We previously identified three glycosylphosphatidylinositol (GPI)-anchored proteins including Ecm33, as multicopy suppressors of the phenotypes of a mutant allele of cis4(+) that encodes a zinc transporter in fission yeast. Here, we further identifie
Externí odkaz:
https://doaj.org/article/92f491c01fd64dfb92425b12fc6adf71
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65904 (2013)
Micafungin is a non-reversible inhibitor of 1, 3-β-D-glucan synthase and interferes with fungal cell wall synthesis. Clinically, micafungin has been shown to be efficacious for the treatment of invasive candidiasis and invasive aspergillosis. Howeve
Externí odkaz:
https://doaj.org/article/caf11a1e38e745018f3fc0f833d6f415
Autor:
Guanglie Jiang, Guoxiang Wu, Hao Miao, Norihiro Sakamoto, Takayoshi Kuno, Fan Yao, Xiaoxu Guo, Si Chen, Kun Liu, Qiannan Liu, Yue Fang
Publikováno v:
Antimicrob Agents Chemother
Invasive fungal diseases are a leading cause of mortality among immunocompromised populations. Treatment is notoriously difficult due to the limited number of antifungal drugs as well as the emergence of drug resistance. Tamoxifen (TAM), a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c3348153ddd52f3a870a3060b13ca0
https://pubmed.ncbi.nlm.nih.gov/32571823
https://pubmed.ncbi.nlm.nih.gov/32571823