Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Takayoshi Kinoshita"'
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
KM12SM-ER cells were treated with siRNAs specific for NTRK1 (siNTRK), VEGFR-2 (siVEGFR-2), MET (siMET), or a scrambled control (siSCR). (A, C) The expression of TRK-A, VEGFR-2 and MET was determined by western blot. (B, D) Cell viability was determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5535a83bbd8ec2965f03cf19dc0da2db
https://doi.org/10.1158/1078-0432.22463982.v1
https://doi.org/10.1158/1078-0432.22463982.v1
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
Tumor cells were treated with 10nM of drugs for indicated time, and harvested lysates were assessed by western blotting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ae911c0fe04b8c2c0943569a3f61fe
https://doi.org/10.1158/1078-0432.22463988.v1
https://doi.org/10.1158/1078-0432.22463988.v1
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
Tumor tissues obtained in the liver metastasis model (Fig. 5) and brain metastasis-mimicking model (Fig. 6) were assessed for microvessel density. Sections of formalin-fixed and paraffin-embedded tissues were stained with anti-mouse CD31 antibody and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df1d298455ddde51bf047112dc014b1
https://doi.org/10.1158/1078-0432.22463976
https://doi.org/10.1158/1078-0432.22463976
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
Tumor cells were treated with various concentrations of drugs for 4 h, and harvested lysates were assessed by western blotting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dab9ef04efdaafa88a8ec73dd287b57
https://doi.org/10.1158/1078-0432.22463991.v1
https://doi.org/10.1158/1078-0432.22463991.v1
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
KM12SM-ER cells were inoculated into the brain of SHO mice. The mice were treated daily with or without entrectinib (15 mg/kg or 30mg/kg) from day 8 to day 17. Mean {plus minus} SE of total flux are shown in the left panel. Representative pictures we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9f6457339a3b66591caa5baa5af228
https://doi.org/10.1158/1078-0432.22463997
https://doi.org/10.1158/1078-0432.22463997
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
KM12SM and EGFP-Eluc-transfected KM12SM (KM12SM/Eluc) cells (2 Ã- 103 per well) were incubated with various concentrations of entrectinib in 96-well flat plates for 72 h. Cell viability was determined using a CCK-8 kit. Data (mean {plus minus} SD of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d907d0ba2f5a27812ac5ecb6fe32f2
https://doi.org/10.1158/1078-0432.22464000
https://doi.org/10.1158/1078-0432.22464000
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
The IC50 value of entrectinib, foretinib and nintedanib against TRK-A, TRK-B and TRK-C human kinases was determined by SignalChem's target profiling service (SignalChem, Richmond, BC, Canada). SignalChem uses a radioisotope assay format for profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7deac4e025a415be5d60c0bdd6389001
https://doi.org/10.1158/1078-0432.22463994
https://doi.org/10.1158/1078-0432.22463994
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
Purpose: Rearrangement of the neurotrophic tropomyosin receptor kinase 1 (NTRK1) gene, which encodes tyrosine receptor kinase A (TRK-A), occurs in various cancers, including colon cancer. Although entrectinib is effective in the treatment of central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781976e3fe5195dfc3250499ca55c78f
https://doi.org/10.1158/1078-0432.c.6525591
https://doi.org/10.1158/1078-0432.c.6525591
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
Body weights of treated mice in the (A) liver metastasis model (Fig. 5) and (B) brain metastasis-mimicking model (Fig. 6) were evaluated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9df63832e5ae53cb2fdfa454a9a5a6
https://doi.org/10.1158/1078-0432.22463979
https://doi.org/10.1158/1078-0432.22463979
Autor:
Seiji Yano, Takayoshi Kinoshita, Noritaka Furuya, Atsushi Tajima, Shoichiro Tange, Shinji Takeuchi, Azusa Tanimoto, Koji Fukuda, Sachiko Arai, Rong Wang, Kenji Kita, Tadaaki Yamada, Akihiro Nishiyama
The coordinates of TRK-A for the docking study of foretinib and entrectinib were prepared from the X-ray structures as stated in the Materials and Methods section. The coordinate of the G595R mutant for the docking study of foretinib was prepared usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acfbbd7b0739cc349f75c187a55c380
https://doi.org/10.1158/1078-0432.22463985.v1
https://doi.org/10.1158/1078-0432.22463985.v1