Chemoproteomics Identifies State-Dependent and Proteoform-Selective Caspase-2 Inhibitors.

Autor: Castellón JO; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States., Ofori S; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States., Burton NR; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Julio AR; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Turmon AC; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Armenta E; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Sandoval C; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095, United States., Boatner LM; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Takayoshi EE; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Faragalla M; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Taylor C; California NanoSystems Institute (CNSI), UCLA, Los Angeles, California 90095, United States., Zhou AL; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Tran K; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Shek J; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Yan T; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Desai HS; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States., Fregoso OI; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095, United States., Damoiseaux R; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California 90095, United States.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, California 90095, United States.; California NanoSystems Institute (CNSI), UCLA, Los Angeles, California 90095, United States.; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California 90095, United States.; Department of Bioengineering, Samueli School of Engineering, UCLA, Los Angeles, California 90095, United States., Backus KM; Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States.; DOE Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095, United States.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California 90095, United States.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, California 90095, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jun 05; Vol. 146 (22), pp. 14972-14988. Date of Electronic Publication: 2024 May 24.

Hif1α and Wnt are required for posterior gene expression during Xenopus tropicalis tail regeneration.

Autor: Patel JH; Department of Biochemistry, University of Washington, Seattle, WA, USA; Program in Molecular and Cellular Biology, University of Washington School of Medicine, Seattle, WA, USA., Schattinger PA; Department of Biochemistry, University of Washington, Seattle, WA, USA., Takayoshi EE; Department of Biochemistry, University of Washington, Seattle, WA, USA., Wills AE; Department of Biochemistry, University of Washington, Seattle, WA, USA; Program in Molecular and Cellular Biology, University of Washington School of Medicine, Seattle, WA, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. Electronic address: aewills@uw.edu.

Publikováno v: Developmental biology [Dev Biol] 2022 Mar; Vol. 483, pp. 157-168. Date of Electronic Publication: 2022 Jan 20.