Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Takayoshi Awakawa"'
Autor:
Zhiyang Quan, Takayoshi Awakawa
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 578-588 (2024)
Meroterpenoids are hybrid compounds that are partially derived from terpenoids. This group of natural products displays large structural diversity, and many members exhibit beneficial biological activities. This mini-review highlights recent advances
Externí odkaz:
https://doaj.org/article/029edf437f3c4c208f727eed356e03cc
Autor:
Takahiro Mori, Takuto Kumano, Haibing He, Satomi Watanabe, Miki Senda, Toshio Moriya, Naruhiko Adachi, Sanae Hori, Yuzu Terashita, Masato Kawasaki, Yoshiteru Hashimoto, Takayoshi Awakawa, Toshiya Senda, Ikuro Abe, Michihiko Kobayashi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
In C-glycosides the sugar moiety is linked through a carbon-carbon bond to the non-sugar moiety, which can be cleaved by intestinal microbes. Here, the authors use bioinformatics analysis to identify C-glycoside deglycosidase enzymes in intestinal an
Externí odkaz:
https://doaj.org/article/be2834e7f7604e8f81be75ba24bda5b8
Autor:
Xiaojun Song, Jianming Lv, Zhiqin Cao, Huiyun Huang, Guodong Chen, Takayoshi Awakawa, Dan Hu, Hao Gao, Ikuro Abe, Xinsheng Yao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1676-1685 (2021)
Fusidane-type antibiotics, represented by helvolic acid, fusidic acid and cephalosporin P1, are fungi-derived antimicrobials with little cross-resistance to commonly used antibiotics. Generation of new fusidane-type derivatives is therefore of great
Externí odkaz:
https://doaj.org/article/08d9453c35ba499baf1cda6c274a63a6
Autor:
Takayoshi Awakawa, Ikuro Abe
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1545-1551 (2019)
Aromatic prenyltransferases (PTases) are enzymes that catalyze Friedel–Crafts reactions between aromatic compounds and isoprenoid diphosphates. In hapalindole biosynthesis, the aromatic PTases AmbP1 and AmbP3 exhibit surprisingly plastic selectivit
Externí odkaz:
https://doaj.org/article/3c537267c24f47d4a6ff1e9749acece5
Autor:
Zhiqin Cao, Shaoyang Li, Jianming Lv, Hao Gao, Guodong Chen, Takayoshi Awakawa, Ikuro Abe, Xinsheng Yao, Dan Hu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 433-442 (2019)
Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However, biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, w
Externí odkaz:
https://doaj.org/article/a809b3780b4d4c5295a2b7fddc6d7f30
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Sulfonamide is in many important drugs yet is rare in nature and little is known about the synthesis of sulfonamide containing antibiotics. Here, the authors report on a detailed analysis of the biosynthesis machineries of the aminoacyl sulfonamide a
Externí odkaz:
https://doaj.org/article/30679522601f44ad84e27c778ada3f8a
Autor:
Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide ra
Externí odkaz:
https://doaj.org/article/209bc4d1b5344a32b292f405caa6ac8b
Autor:
Gao-Qian Wang, Guo-Dong Chen, Sheng-Ying Qin, Dan Hu, Takayoshi Awakawa, Shao-Yang Li, Jian-Ming Lv, Chuan-Xi Wang, Xin-Sheng Yao, Ikuro Abe, Hao Gao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Demethoxyviridin is a fungal steroid that inhibits a phosphatidylinositol 3-kinase, an enzyme contributing to tumor progression. Here, the authors elucidate the biosynthetic route that leads to the formation of demethoxyviridin in fungi.
Externí odkaz:
https://doaj.org/article/f30a4248c8d1480983d411fc8c04ad53
Autor:
Yu Nakashima, Takahiro Mori, Hitomi Nakamura, Takayoshi Awakawa, Shotaro Hoshino, Miki Senda, Toshiya Senda, Ikuro Abe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Non-heme iron and α-ketoglutarate (αKG) oxygenases play a major role in fungal meroterpenoid biosynthesis, but their mechanism remains elusive. Here the authors present crystal structures of two oxygenases, AusE and PrhA, which provide insights int
Externí odkaz:
https://doaj.org/article/a9d82d60fc91499ea620314cccccd36f
Autor:
Jian-Ming Lv, Dan Hu, Hao Gao, Tetsuo Kushiro, Takayoshi Awakawa, Guo-Dong Chen, Chuan-Xi Wang, Ikuro Abe, Xin-Sheng Yao
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The biosynthetic pathway of fusidane-type antibiotics, such as helvolic acid, is largely undiscovered. Here, the authors investigate the biosynthesis of helvolic acid, thereby determining the sequence of the enzymatic reactions involved in the proces
Externí odkaz:
https://doaj.org/article/9d043d8d1f0e4010b686b64da0e4c8b7