Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Takayoshi, Suganami"'
Autor:
Yoshiki Shinoda, Hideki Tatsukawa, Atsushi Yonaga, Ryosuke Wakita, Taishu Takeuchi, Tokuji Tsuji, Miyako Tanaka, Takayoshi Suganami, Kiyotaka Hitomi
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-14 (2023)
Abstract Macrophages are important components in modulating homeostatic and inflammatory responses and are generally categorized into two broad but distinct subsets: classical activated (M1) and alternatively activated (M2) depending on the microenvi
Externí odkaz:
https://doaj.org/article/60a8363128b6446cb25e9a900b1c1a02
Autor:
Hisashi Kato, Kaori Iwashita, Masayo Iwasa, Sayaka Kato, Hajime Yamakage, Takayoshi Suganami, Masashi Tanaka, Noriko Satoh-Asahara
Publikováno v:
Cells, Vol 13, Iss 3, p 284 (2024)
Type 2 diabetes mellitus (T2DM) is an epidemiological risk factor for dementia and has been implicated in multifactorial pathologies, including neuroinflammation. In the present study, we aimed to elucidate the potential anti-inflammatory effects of
Externí odkaz:
https://doaj.org/article/ea5f729723444c16856b97dc1c9981ec
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-8 (2022)
Abstract Chronic inflammation is currently considered as a molecular basis of metabolic syndrome. Particularly, obesity-induced inflammation in adipose tissue is the origin of chronic inflammation of metabolic syndrome. Adipose tissue contains not on
Externí odkaz:
https://doaj.org/article/7afadefcfee94a9992d0a364c3033fc5
Autor:
Ryuji Ohue-Kitano, Hazuki Nonaka, Akari Nishida, Yuki Masujima, Daisuke Takahashi, Takako Ikeda, Akiharu Uwamizu, Miyako Tanaka, Motoyuki Kohjima, Miki Igarashi, Hironori Katoh, Tomohiro Tanaka, Asuka Inoue, Takayoshi Suganami, Koji Hase, Yoshihiro Ogawa, Junken Aoki, Ikuo Kimura
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Medium-chain triglycerides (MCTs), which consist of medium-chain fatty acids (MCFAs), are unique forms of dietary fat with various health benefits. G protein–coupled 84 (GPR84) acts as a receptor for MCFAs (especially C10:0 and C12:0); however, GPR
Externí odkaz:
https://doaj.org/article/ecafa7ca37954e389e6d0e6f51ad1a89
Autor:
Kento Kurita, Hiroya Ohta, Ibuki Shirakawa, Miyako Tanaka, Yasuyuki Kitaura, Yorihiro Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Seiichiro Aoe, Hiroshi Arima, Yoshihiro Ogawa, Ayaka Ito, Takayoshi Suganami
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract A growing body of evidence indicates that cellular metabolism is involved in immune cell functions, including cytokine production. Serine is a nutritionally non-essential amino acid that can be generated by de novo synthesis and conversion f
Externí odkaz:
https://doaj.org/article/c78ccae1fd384490939f7565d66e5db1
Autor:
Takayuki Watanabe, Atsunori Tsuchiya, Suguru Takeuchi, Shunsuke Nojiri, Tomoaki Yoshida, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai
Publikováno v:
Regenerative Therapy, Vol 14, Iss , Pp 252-261 (2020)
Introduction: Currently, there are no approved drugs for treating non-alcoholic steatohepatitis (NASH); however, mesenchymal stem cells (MSCs) and their small extracellular vesicles (sEVs), which possess immunomodulatory activities, are potential can
Externí odkaz:
https://doaj.org/article/6607854cb2f4474e85ae67ab042f51ae
Autor:
Azusa Kobayashi, Ayaka Ito, Ibuki Shirakawa, Atsushi Tamura, Susumu Tomono, Hideo Shindou, Per Niklas Hedde, Miyako Tanaka, Naotake Tsuboi, Takuji Ishimoto, Sachiko Akashi-Takamura, Shoichi Maruyama, Takayoshi Suganami
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To
Externí odkaz:
https://doaj.org/article/15704b94f80744bbb9fe0cc111083c27
Autor:
Yohei Kanamori, Miyako Tanaka, Michiko Itoh, Kozue Ochi, Ayaka Ito, Isao Hidaka, Isao Sakaida, Yoshihiro Ogawa, Takayoshi Suganami
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102032- (2021)
Summary: Although recent evidence suggests the involvement of iron accumulation in the pathogenesis of nonalcoholic steatohepatitis (NASH), the underlying mechanisms remain poorly understood. Previously, we reported a unique histological structure te
Externí odkaz:
https://doaj.org/article/16a03f7777ad4768bb6009dc684fd2ff
Autor:
Siyuan Chen, Takuya Miyazaki, Michiko Itoh, Hiroko Matsumoto, Yuki Moro-oka, Miyako Tanaka, Yuji Miyahara, Takayoshi Suganami, Akira Matsumoto
Publikováno v:
Gels, Vol 8, Iss 2, p 74 (2022)
Recently, phenylboronic acid (PBA) gel containing microneedle (MN) technology with acute and sustained glucose-sensitive functionality has attracted significant research attention. Herein, we report a polyvinyl alcohol(PVA)-coated MNs patch with an i
Externí odkaz:
https://doaj.org/article/ab4389c8296a41d294993d58bce4527a
Autor:
Kumiko Shiba, Kyoichiro Tsuchiya, Chikara Komiya, Yasutaka Miyachi, Kentaro Mori, Noriko Shimazu, Shinobu Yamaguchi, Naomi Ogasawara, Makoto Katoh, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic st
Externí odkaz:
https://doaj.org/article/f40c5869250d4118846a58308f7da1f5