Výsledky vyhledávání - "Takayasu Date"

Cell sorting analysis of cell cycle-dependent X-ray sensitivity in end joining-deficient human cells

Autor: Kuniyoshi Iwabuchi, Tadashi Matsui, Takayasu Date, Mitsumasa Hashimoto, Noritaka Adachi, Aya Kurosawa

Publikováno v: Biochemical and Biophysical Research Communications. 372:662-667

Non-homologous end joining (NHEJ) plays a major role in the repair of ionizing radiation-induced DNA double-strand breaks (DSBs), especially during the G1-phase of the cell cycle. Using a flow cytometric cell sorter, we fractionated G1- and S/G2-phas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cf2c4384559c917524ef07f91fea2c
https://doi.org/10.1016/j.bbrc.2008.05.147

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Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells

Autor: Tsukasa Matsunaga, Megumi Matsumoto, Kuniyoshi Iwabuchi, Kanji Ishizaki, Mayumi Imura, Toshio Mori, Manabu Inobe, Mizuho Hasegawa, Takayasu Date, Kie Yaginuma, Ai Igarashi, Katsumi Yamashita

Publikováno v: Journal of Cell Science. 120:1104-1112

Human histone H2AX is rapidly phosphorylated on serine 139 in response to DNA double-strand breaks and plays a crucial role in tethering the factors involved in DNA repair and damage signaling. Replication stress caused by hydroxyurea or UV also init

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ecd8d1a56a208c5b39d85a7fefcb4d
https://doi.org/10.1242/jcs.03391

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High mobility Group I-C protein in astrocytoma and glioblastoma

Autor: Shogo Katsuda, Tomio Hamada, Yasunori Okada, Takayasu Date, Hideaki Iizuka, Yoshimichi Ueda, Yasuo Sasagawa, Kiran Chada, Takuya Akai

Publikováno v: Pathology - Research and Practice. 200:619-624

High mobility group I-C (HMGI-C) protein is a non-histone DNA-binding factor that organizes active chromatin. This protein is expressed during the limited phase of embryonic development and may regulate the expression of genes critical for embryonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3f18a3f84d840d28e833edca58e3f5
https://doi.org/10.1016/j.prp.2004.06.008

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Expression of Unphosphorylated Form of Human Double-Stranded RNA-Activated Protein Kinase in Escherichia coli

Autor: Kiyomi Tanihara, Takayasu Date, Tadashi Matsui

Publikováno v: Biochemical and Biophysical Research Communications. 284:798-807

Interferon (IFN)-inducible, double-stranded (dsRNA)-activated protein kinase (PKR) is a key mediator of the antiviral and antiproliferative effects of IFN. PKR is present within cells in a latent state. In response to binding dsRNA, the enzyme become

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918b89fd34560816b05234353a3d473b
https://doi.org/10.1006/bbrc.2001.5039

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Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

Autor: Takayasu Date, Junjie Chen, Kuniyoshi Iwabuchi, Irene Rappold

Publikováno v: The Journal of Cell Biology

The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of p53 and enhances p53-mediated transcriptional activation. 53BP1 contains two breast cancer susceptibility gene 1 COOH terminus (BRCT) motifs, which are present in s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4098de407e2291a877b41613272d52ba
https://doi.org/10.1083/jcb.153.3.613

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Mode Analysis of a Fatty Acid Molecule Binding to the N-terminal 8-kDa Domain of DNA Polymerase β

Autor: Takayasu Date, Mineo Saneyoshi, Toyofumi Yamaguchi, Fumio Sugawara, Kengo Sakaguchi, Yoshiyuki Mizushina, Tadayasu Ohkubo

Publikováno v: Journal of Biological Chemistry. 274:25599-25607

We reported previously that long-chain fatty acids are potent inhibitors of mammalian DNA polymerase beta. At present, based on information available from the NMR structure of the N-terminal 8-kDa domain, we examined the structural interaction with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85e0dba7c2f926a1d5a3a90b850bef85
https://doi.org/10.1074/jbc.274.36.25599

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Rat Liver Serine Dehydratase

Autor: Kunihiko Wakaki, Mohammad R. Eskandarian, Masashi Kobayashi, Takayasu Date, Num-Ho Huh, Hirofumi Ogawa, Henry C. Pitot, Fusao Takusagawa, Hiroyuki Kishi

Publikováno v: Journal of Biological Chemistry. 274:12855-12860

A pCW vector harboring rat liver serine dehydratase cDNA was expressed in Escherichia coli. The expressed level was about 5-fold higher in E. coli BL21 than in JM109 cell extract; the former lacked two kinds of proteases. Immunoblot analysis revealed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7853677c268828caef45380b524226d
https://doi.org/10.1074/jbc.274.18.12855

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Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2

Autor: Barbara J. Trask, Stanley Fields, Bin Li, Takayasu Date, Kuniyoshi Iwabuchi, Hillary Massa

Publikováno v: Journal of Biological Chemistry. 273:26061-26068

p53 is a tumor suppressor protein that controls cell proliferation by regulating the expression of growth control genes. In a previous study, we identified two proteins, 53BP1 and 53BP2, that are able to bind to wild type but not to mutant p53 via th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afd63de65df21c56d38cace0f45c678
https://doi.org/10.1074/jbc.273.40.26061

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