Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome‐Wide Association and Mendelian Randomization Study

Autor: Kosuke Inoue, Tatsuhiko Naito, Ryosuke Fuji, Kyuto Sonehara, Kenichi Yamamoto, Ryuta Baba, Takaya Kodama, Yu Otagaki, Akira Okada, Kiyotaka Itcho, Kazuhiro Kobuke, Haruya Ohno, Takayuki Morisaki, Noboru Hattori, Atsushi Goto, Tetsuo Nishikawa, Kenji Oki, Yukinori Okada

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 15 (2024)

Background Observational studies have reported associations between primary aldosteronism (PA) and cardiovascular outcomes, including coronary artery diseases (CAD), congestive heart failure (CHF), and stroke. However, establishing causality remains

Externí odkaz: https://doaj.org/article/d8c02857d41640e2a219bc6762859cf6

ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

Autor: Elise P. Gomez-Sanchez, Masayasu Yoneda, Kazuhiro Kobuke, Kiyotaka Itcho, Kenji Oki, Koji Arihiro, Yoko Yoshii, Celso E. Gomez-Sanchez, Noboru Hattori, Takaya Kodama, Haruya Ohno, Ryuta Baba, Gaku Nagano

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 10981, p 10981 (2021)

The molecular mechanisms by which ATP1A1 mutation-mediated cell proliferation or tumorigenesis in aldosterone-producing adenomas (APAs) have not been elucidated. First, we investigated whether the APA-associated ATP1A1 L104R mutation stimulated cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba4cddab63b226e06ac973c09b88168
http://europepmc.org/articles/PMC8537586

Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma

Autor: Yuta Nanao, Kenji Oki, Kazuhiro Kobuke, Kiyotaka Itcho, Ryuta Baba, Takaya Kodama, Yu Otagaki, Akira Okada, Yoko Yoshii, Gaku Nagano, Haruya Ohno, Koji Arihiro, Celso E. Gomez-Sanchez, Noboru Hattori, Masayasu Yoneda

Publikováno v: Mol Cell Endocrinol

DNA methylation alteration is tissue-specific and play a pivotal role in regulating gene transcription during cell proliferation and survival. We aimed to detect genes regulated by DNA methylation, and then investigated whether the gene influenced ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9597ce93b4d05f80d9417df9a1c08a
https://doi.org/10.1016/j.mce.2022.111613

Diffuse sclerosing variant of papillary carcinoma of the thyroid: Clinical importance, surgical treatment, and follow-up study

Autor: Kazuyoshi Yamaguchi, Yukio Ito, Takaya Kodama, Takao Obara, Motohiko Aiba, Yoshihide Fujimoto

Publikováno v: Cancer. 66:2306-2312

A diffuse sclerosing variant is not very rare among papillary carcinomas of the thyroid when the patients are female and younger than 30 years of age. The variant is characterized by diffuse involvement of one or both thyroid lobes, with dense sclero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68aebd602be6039ceb59feb7fdda1f3
https://doi.org/10.1002/1097-0142(19901201)66:11<2306::aid-cncr2820661109>3.0.co

Flow cytometric DNA analysis of parathyroid tumors. Implication of aneuploidy for pathologic and biologic classification

Autor: Yukio Ito, Takahiro Okamoto, Yoshiharu Kanaji, Akira Hirayama, Takaya Kodama, Yoshihide Fujimoto, Takao Obara

Publikováno v: Cancer. 66(7)

The previous cytometric studies on parathyroid tumors have provided conflicting data regarding the relationship between DNA content and histopathology, resulting from differences in technical methods and data analysis. This study measured nuclear DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c4d940dd8aaf46ca62dfa77d826654
https://pubmed.ncbi.nlm.nih.gov/2208008