Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Takatsugu Hirokawa"'
Autor:
Genki Kudo, Takumi Hirao, Ryuhei Harada, Takatsugu Hirokawa, Yasuteru Shigeta, Ryunosuke Yoshino
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract DNA methylation is an epigenetic mechanism that introduces a methyl group at the C5 position of cytosine. This reaction is catalyzed by DNA methyltransferases (DNMTs) and is essential for the regulation of gene transcription. The DNMT1 and D
Externí odkaz:
https://doaj.org/article/b38df8e4c2e54e1aaa78f6499faa8322
Autor:
Julia Kitadokoro, Shigeki Kamitani, Yukiko Okuno, Takaaki Hikima, Masaki Yamamoto, Takatsugu Hirokawa, Kengo Kitadokoro
Publikováno v:
FEBS Open Bio, Vol 14, Iss 6, Pp 942-954 (2024)
Staphylococcus aureus produces large amounts of toxins and virulence factors. In patients with underlying diseases or compromised immune systems, this bacterium can lead to severe infections and potentially death. In this study, the crystal structure
Externí odkaz:
https://doaj.org/article/2ffb2b6eb7ce490eb27f195ce6afdcb6
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Driving mechanisms of many biological functions in a cell include physical interactions of proteins. As protein-protein interactions (PPIs) are also important in disease development, protein-protein interactions are highlighted in the pharmaceutical
Externí odkaz:
https://doaj.org/article/3fd5b256ffec4182b022024f43952255
Autor:
Kazue Inaba, Kana Ebihara, Miki Senda, Ryunosuke Yoshino, Chisako Sakuma, Kotaro Koiwai, Daisuke Takaya, Chiduru Watanabe, Akira Watanabe, Yusuke Kawashima, Kaori Fukuzawa, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Nozomi Uemura, Shinji Kasai, Hirotaka Kanuka, Takashi Nishimura, Kodai Watanabe, Hideshi Inoue, Yuuta Fujikawa, Teruki Honma, Takatsugu Hirokawa, Toshiya Senda, Ryusuke Niwa
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Background Mosquito control is a crucial global issue for protecting the human community from mosquito-borne diseases. There is an urgent need for the development of selective and safe reagents for mosquito control. Flavonoids, a group of ch
Externí odkaz:
https://doaj.org/article/b49433e4465946a08dd1ecf88c040e05
Autor:
Atsushi Hijikata, Clara Shionyu‐Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 285-294 (2022)
Cepharanthine (CEP) is a natural biscoclaurine alkaloid of plant origin and was recently demonstrated to have anti‐severe acute respiratory syndrome coronavirus 2 (anti‐SARS‐CoV‐2) activity. In this study, we evaluated whether natural analogu
Externí odkaz:
https://doaj.org/article/107db267d382427094cc9f1a9c93c0be
Autor:
Motohiro Sekiya, Kenta Kainoh, Takehito Sugasawa, Ryunosuke Yoshino, Takatsugu Hirokawa, Hiroaki Tokiwa, Shogo Nakano, Satoru Nagatoishi, Kouhei Tsumoto, Yoshinori Takeuchi, Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Sensing of nutrient status coordinates the regulation of liver glucose and lipid metabolism, and is important for metabolic homeostasis. Here the authors report that transcriptional the corepressor CtBP2 can sense nutrient status and coordinate repre
Externí odkaz:
https://doaj.org/article/996f1a434a0445a0ba8691377b30fab1
Autor:
Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1036 (2023)
Vitamin D3 (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D3 (6a) and 4β,25-dihydroxyvitamin D3 (6b) are both produced from 25-hydroxyvitamin D3 (2)
Externí odkaz:
https://doaj.org/article/c5b86fd457e040e49e31682f095f8413
Autor:
Eiko Uezono, Yusuke Mizobuchi, Kanako Miyano, Katsuya Ohbuchi, Hiroaki Murata, Akane Komatsu, Sei Manabe, Miki Nonaka, Takatsugu Hirokawa, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida, Izumi Kawagoe
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8369 (2023)
Remifentanil (REM) and fentanyl (FEN) are commonly used analgesics that act by activating a µ-opioid receptor (MOR). Although optimal concentrations of REM can be easily maintained during surgery, it is sometimes switched to FEN for optimal pain reg
Externí odkaz:
https://doaj.org/article/6b2a585b9013486aa88a2d3221e978ac
Autor:
Keiko Fukasawa, Mari Gotoh, Akiharu Uwamizu, Takatsugu Hirokawa, Masaki Ishikawa, Yoshibumi Shimizu, Shinji Yamamoto, Kensuke Iwasa, Keisuke Yoshikawa, Junken Aoki, Kimiko Murakami-Murofushi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo. Although
Externí odkaz:
https://doaj.org/article/e959ecf2a7d64653976c5ac68bc4d772
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Ras mutations (e.g., occur in K-Ras, N-Ras, and H-Ras) are one of the most desirable and promising drug targets in chemotherapy treatments for cancer. However, there are still no approved drugs directly targeting mutated Ras. In 2017, an art
Externí odkaz:
https://doaj.org/article/1169d92c6a314ea185bfdf3f8304635f