Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Takatoshi Yogo"'
Autor:
Taisuke Katoh, Tomoya Sameshima, Masato Yoshikawa, Tomoya Yukawa, Hideto Hara, Takatoshi Yogo, Russell Naven, Makoto Miyamoto, Ikuo Miyahisa, Yoshihiko Hirozane, Teruaki Okuda
Publikováno v:
Chemical Research in Toxicology. 33:154-161
Despite the recent advances in the life sciences and the remarkable investment in drug discovery research, the success rate of small-molecule drug development remains low. Safety is the second most influential factor of drug attrition in clinical stu
Autor:
Masato Yoshikawa, Tomoya Sameshima, Yoshihiko Hirozane, Masashi Toyofuku, Yukiya Tanaka, Takatoshi Yogo, Ikuo Miyahisa
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(21)
Selectivity profiling of compounds is important for kinase drug discovery. To this end, we aimed to develop a broad-range protein kinase assay by synthesizing a novel staurosporine-derived fluorescent probe based on staurosporine and kinase-binding r
Autor:
Harumi Hattori, Morihisa Saitoh, Yoshihisa Nakada, Kumar Singh Saikatendu, Yuji Shimizu, Masako Kuno, Hua Zou, Taisuke Katoh, Masato Yoshikawa, Seki Tomohiro, Masanori Nakakariya, Etsuro Watanabe, Takuro Okai, Takayuki Tatamiya, Takatoshi Yogo, Tsuyoshi Ishii, Simone V. Bigi
Publikováno v:
Journal of medicinal chemistry. 61(6)
We report the discovery of 7-oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine derivatives as a novel class of receptor interacting protein 1 (RIP1) kinase inhibitors. On the basis of the overlay study between HTS hit 10 and GSK2982772 (6) in RIP1
Autor:
Tsuyoshi Ishii, Masako Kuno, Masato Yoshikawa, Manabu Mochizuki, Tomohiro Kawamoto, Takuro Okai, Sachio Shibata, Takatoshi Yogo, Masanori Nakakariya, Misa Iwatani-Yoshihara, Satoko Unno
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
The proof of target engagement (TE) is a key element for evaluating potential investment in drug development. The cellular thermal shift assay (CETSA) is expected to facilitate direct measurement of intracellular TE at all stages of drug development.
Autor:
Noriyuki Nii, Nobuyuki Negoro, Shinkichi Suzuki, Ryoukichi Koyama, Taisuke Katoh, Masato Yoshikawa, Ryosuke Arai, Takatoshi Yogo, Yoshihide Tomata, Takeshi Yamamoto
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
We describe a methodology for quick development of fluorescent probes with the desired potency for the target of interest by using a method of parallel synthesis, termed as Parallel Fluorescent Probe Synthesis (Parallel-FPS). BODIPY FL propionic acid
Autor:
Masako Kuno, Huang Shih-Chung, Gil Nam Lee, Syunsuke Yamamoto, Suk Young Cho, Kazuyoshi Aso, Masato Yoshida, Shogo Marui, Norihito Tokunaga, Yusuke Ohba, Takatoshi Yogo, Hideyuki Nakagawa, Satoshi Sasaki, Masaki Seto, Atsutoshi Okabe, Takahiro Miyazaki, Chul Yun Rhim, Yousuke Satou, Robert J. Skene, Cheol Hwan Yoon, Hiroyuki Nagamiya
Publikováno v:
Journal of medicinal chemistry. 59(2)
We report herein the discovery and optimization of 3-amino-1,5-dihydro-4H-pyrazolopyridin-4-one TYK2 inhibitors. High-throughput screening against TYK2 and JAK1-3 provided aminoindazole derivative 1 as a hit compound. Scaffold hopping of the aminoind
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4320-4323
Photosensitizers produce cytotoxic reactive oxygen species (ROS) upon light illumination, but it is difficult to ablate cells of a specific type (e.g., tumor cells) in the presence of other cell populations, because of the limited precision with whic
Autor:
Hisato Sunahara, Yasuteru Urano, Tetsuo Nagano, Kenzo Hirose, Takanari Inoue, Masamitsu Iino, Akiko Mizushima, Takatoshi Yogo, Kazuya Kikuchi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(1)
Chromophore-assisted light inactivation is a promising technique to inactivate selected proteins with high spatial and temporal resolution in living cells, but its use has been limited because of the lack of a methodology to prevent nonspecific photo
Publikováno v:
Chemistrybiology. 11(8)
A membrane-permeant malachite green-conjugated IP3 analog (MGIP3/PM) was synthesized as a probe for small molecule-based CALI (smCALI), and its effect on the Ca2+ signaling in intact DT40 chicken B cells was examined. In DT40 B cells treated with the
Autor:
Takatoshi Yogo, Hiroyuki Nagamiya, Masaki Seto, Satoshi Sasaki, Huang Shih-Chung, Yusuke Ohba, Norihito Tokunaga, Gil Nam Lee, Chul Yun Rhim, Cheol Hwan Yoon, Suk Young Cho, Robert Skene, Syunsuke Yamamoto, Yousuke Satou, Masako Kuno, Takahiro Miyazaki, Hideyuki Nakagawa, Atsutoshi Okabe, Shogo Marui, Kazuyoshi Aso
Publikováno v:
Journal of Medicinal Chemistry; Jan2016, Vol. 59 Issue 2, p733-749, 17p