Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Takatoshi Otonari"'
Autor:
Kazumasa Harada, Takumi Imai, Hidenori Arai, Kazuo Sakabe, Yasuo Katayama, Shiro Tanaka, Naoto Yokota, Takao Urabe, Koutaro Yokote, Yasuo Ohashi, Shinichi Oikawa, Takashi Kobayashi, Shizuya Yamashita, Yasufumi Uchida, Masayasu Yamamoto, Hirokazu Nishida, Hideki Ito, Masanari Kuwabara, Jun Sasaki, Ichiro Sakuma, Masaru Hayashi, Yasuyoshi Ouchi, Hiromi Rakugi, Takatoshi Otonari, Tadashi Arai
Publikováno v:
Circulation. 140:992-1003
Background: Evidence regarding the primary prevention of coronary artery disease events by low-density lipoprotein cholesterol (LDL-C) lowering therapy in older individuals, aged ≥75 years, is insufficient. This trial tested whether LDL-C–lowerin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56fb9e29f5d67d43f77e2743a0b68743
https://doi.org/10.1161/circulationaha.118.039415
https://doi.org/10.1161/circulationaha.118.039415
Autor:
Mitsuhiro Tominaga, Junya Kawasaki, Hisatomi Arima, Yuki Morinaga, Comfort Investigators, Masayo Fukuhara, Yuko Ohta, Toshio Ohtsubo, Isao Kato, Toshiyuki Sasaguri, Takuya Tsuchihashi, Takatoshi Otonari, Kiyoshi Matsumura, Koji Fujii, Keiko Uezono
Publikováno v:
Clinical and Experimental Hypertension. 37:192-196
It has been shown that losartan, an angiotensin II receptor blocker (ARB), reduces serum uric acid levels. However, the effects of losartan on serum uric acid levels in the patients treated with a thiazide diuretic have not been fully elucidated. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e55c89ecc76bfad57a2a5f1099f433c
https://doi.org/10.3109/10641963.2014.933968
https://doi.org/10.3109/10641963.2014.933968
Autor:
Shinichi Oikawa, Takeshi Inazawa, Yasushi Nakajima, Takatoshi Otonari, Taro Harada, Fumitaka Okajima, Hitoshi Sugihara, Masanobu Kawakami, Hideki Tamura, Mototsugu Nagao, Kyoko Tanimura-Inagaki
Publikováno v:
Journal of Diabetes Investigation
Aims/Introduction α-Glucosidase inhibitors (αGIs) are widely used for the primary treatment of type 2 diabetes. We compared the clinical effects of three αGIs (miglitol, acarbose and voglibose) in patients with obese type 2 diabetes. Materials and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f515510cf62883320d58e700995689
https://doi.org/10.1111/jdi.12135
https://doi.org/10.1111/jdi.12135
Autor:
Jun, Sasaki, Takatoshi, Otonari, Yasunori, Sawayama, Shiro, Hata, Yoshimi, Oshima, Tetsunori, Saikawa, Sadatoshi, Biro, Suminori, Kono, S, Suzuki
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 19:485-493
Aim This study compared the effect of doubling the dose of pravastatin with that of adding ezetimibe to low-dose pravastatin on the LDL cholesterol (LDL-C) level and on cholesterol absorption and synthesis markers. The tolerability of the 2 regimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c61a1620c806e2b262d85328287d085
https://doi.org/10.5551/jat.12013
https://doi.org/10.5551/jat.12013
Autor:
Syozou Kobori, Tetsunori Saikawa, Keizou Kajiwara, Masato Ageta, Yoshihiko Ikeda, Tadanobu Kuribayashi, Kyosuke Yamamoto, Suminori Kono, Jun Sasaki, Sadatoshi Biro, Takatoshi Otonari
Publikováno v:
Clinical Therapeutics. 30:1089-1101
Statin therapy has been found to produce substantial reductions in low-density lipoprotein cholesterol (LDL-C) levels, resulting in a reduced risk for cardiovascular events. Recently, research interest has focused on modification of high-density lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7c26d72120506fbb20658afd13e06f
https://doi.org/10.1016/j.clinthera.2008.05.017
https://doi.org/10.1016/j.clinthera.2008.05.017
Autor:
Takatoshi Otonari, Jun Sasaki, Tetsunori Saikawa, Sadatoshi Biro, Yasunori Sawayama, Hachiro Obata, Masato Ageta, Suminori Kono
Publikováno v:
Clinical Pharmacology & Biopharmaceutics. 3
Activation of renin angiotensin system is implicated in insulin resistance. In mega trials, it has been suggested that angiotensin receptor blockers may be beneficial on insulin sensitivity in hypertensive patients. We conducted a multicenter, open-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cf23df9b55a84264c36f26245c5f2d5
https://doi.org/10.4172/2167-065x.1000118
https://doi.org/10.4172/2167-065x.1000118
Autor:
Mitsuhiro Tominaga, Kiyoshi Matsumura, Takatoshi Otonari, Hisatomi Arima, Yuko Ohta, Yuki Morinaga, Toshiyuki Sasaguri, Toshio Ohtsubo, Comfort Investigators, Isao Kato, Masayo Fukuhara, Takuya Tsuchihashi, Junya Kawasaki, Keiko Uezono, Koji Fujii
Publikováno v:
QJM : monthly journal of the Association of Physicians. 106(10)
Background: It has not been fully elucidated whether antihypertensive medication adherence affects blood pressure (BP) control in hypertension cases. Aim: To investigate the association of adherence to antihypertensive drug regimens and BP control us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b2e64c96f5a1823d44611ab3db1c98
https://pubmed.ncbi.nlm.nih.gov/23696676
https://pubmed.ncbi.nlm.nih.gov/23696676
Autor:
Jun, Sasaki, Takatoshi, Otonari, Yasufumi, Uchida, Yoshihiko, Ikeda, Sadatoshi, Biro, Suminori, Kono, K, Gondo
Publikováno v:
Journal of atherosclerosis and thrombosis. 20(4)
Aims: While statins have the property of increasing high-density lipoprotein cholesterol (HDL-C) in addition to lowering low-density lipoprotein cholesterol (LDL-C), a potential adverse effect on glucose metabolism has raised a concern over statin th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc94ba333988f83e7aac50142bc6fc53
https://pubmed.ncbi.nlm.nih.gov/23257975
https://pubmed.ncbi.nlm.nih.gov/23257975
Autor:
Kiyoshi, Matsumura, Hisatomi, Arima, Mitsuhiro, Tominaga, Toshio, Ohtsubo, Toshiyuki, Sasaguri, Koji, Fujii, Masayo, Fukuhara, Keiko, Uezono, Yuki, Morinaga, Yuko, Ohta, Takatoshi, Otonari, Junya, Kawasaki, Isao, Kato, Takuya, Tsuchihashi, Morioki, Ishibashi
Publikováno v:
Circulation journal : official journal of the Japanese Circulation Society. 76(6)
Background: In order to achieve target blood pressure levels to prevent cardiovascular disease, combination therapy of antihypertensive drugs is often required, although it is thought that requiring a patient to take many different pills would reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce4dbbb3530b7ab34bf30596ea447bf
https://pubmed.ncbi.nlm.nih.gov/22447014
https://pubmed.ncbi.nlm.nih.gov/22447014
Autor:
Tetsunori, Saikawa, Jun, Sasaki, Sadayoshi, Biro, Suminori, Kono, Takatoshi, Otonari, Yoshiyuki, Ikeda, S, Kono
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 33(9)
Whether the reno-protective effect of angiotensin receptor blockers is dose dependent is unknown for the Japanese population. We sought to elucidate the dose-dependent reno-protective effects of valsartan in Japanese hypertensive patients with albumi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2615f350c93dfaf966c37fe0ca92a524
https://pubmed.ncbi.nlm.nih.gov/20555331
https://pubmed.ncbi.nlm.nih.gov/20555331