IL-33 Is Essential for Adjuvant Effect of Hydroxypropyl-β-Cyclodexrin on the Protective Intranasal Influenza Vaccination

Autor: Shingo Kobari, Takato Kusakabe, Masatoshi Momota, Takayuki Shibahara, Tomoya Hayashi, Koji Ozasa, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Shuichi Ito, Etsushi Kuroda, Ken J. Ishii

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Vaccine adjuvants are traditionally used to augment and modulate the immunogenicity of vaccines, although in many cases it is unclear which specific molecules contribute to their stimulatory activity. We previously reported that both subcutaneous and

Externí odkaz: https://doaj.org/article/e46abc3c4835404a8f47a34fabbb8a4c

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Autor: Tomoya Hayashi, Masatoshi Momota, Etsushi Kuroda, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S. J. Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J. Ishii, Hidetoshi Arima

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing ho

Externí odkaz: https://doaj.org/article/ad7b4fe64f98488ebd2bc9094ccbfdcc

Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn’s disease

Autor: William D. Fiers, Jesús Pla, Randy S. Longman, Woan-Yu Lin, Irina Leonardi, Patrick C Wilson, Iliyan D. Iliev, Meghan Bialt-DeCelie, Itai Doron, Xin Li, Dustin G. Shaw, Takato Kusakabe, Elvira Román, Marissa Mesko

Publikováno v: Nature Microbiology. 6:1493-1504

Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection by shaping the resident microbiota community, restricting the growth of bacterial pathogens and enhancing host protective immunity via immunological exclusion. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e8b38ce8f7c82c5865965a9713b4cb4
https://doi.org/10.1038/s41564-021-00983-z

Immune regulation by fungal strain diversity in inflammatory bowel disease

Autor: Xin V. Li, Irina Leonardi, Gregory G. Putzel, Alexa Semon, William D. Fiers, Takato Kusakabe, Woan-Yu Lin, Iris H. Gao, Itai Doron, Alejandra Gutierrez-Guerrero, Meghan B. DeCelie, Guilhermina M. Carriche, Marissa Mesko, Chen Yang, Julian R. Naglik, Bernhard Hube, Ellen J. Scherl, Iliyan D. Iliev

Publikováno v: Li, X V, Leonardi, I, Putzel, G G, Semon, A, Fiers, W D, Kusakabe, T, Lin, W-Y, Gao, I H, Doron, I, Gutierrez-Guerrero, A, DeCelie, M B, Mesko, M, Chen, Y, Naglik, J R, Hube, B, Scherl, E J & Iliev, I D 2022, ' Immune regulation by fungal strain diversity in inflammatory bowel disease ', NATURE, vol. 603, no. 7902, pp. 672-678 . https://doi.org/10.1038/s41586-022-04502-w
Nature

The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has an important role in immune regulation1,2,3,4,5,6. Although aberrant changes in the mycobiot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e70399a7894d340f4b7da93db72b2df
https://kclpure.kcl.ac.uk/en/publications/b6cc3903-a678-4ec5-b9df-57dcaa1eda45

Author Correction: Immune regulation by fungal strain diversity in inflammatory bowel disease

Autor: Xin V. Li, Irina Leonardi, Gregory G. Putzel, Alexa Semon, William D. Fiers, Takato Kusakabe, Woan-Yu Lin, Iris H. Gao, Itai Doron, Alejandra Gutierrez-Guerrero, Meghan B. DeCelie, Guilhermina M. Carriche, Marissa Mesko, Chen Yang, Julian R. Naglik, Bernhard Hube, Ellen J. Scherl, Iliyan D. Iliev

Publikováno v: Nature. 608:E21-E21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ab31da7ced270c0a2541e9783c48b53
https://doi.org/10.1038/s41586-022-05102-4