Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Takashi Yamoto"'
Autor:
Takashi Yamoto, Kazuhiko Mori, Yumi Nishiya, Kyoko Watanabe, Yuki Kishino, Ayako Kato, Tomoko Hasegawa, Wataru Takasaki, Veronika Rozhnal
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 838:37-45
We investigated the relationship between metabolic activities of cytochrome P450 (CYP) isozymes present in microsomal fractions derived from the livers of 78 donors and micronucleus induction by cyclophosphamide (CPA). Consequently, a wide inter-indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee486c49bd6203dfc26b603a427f26b
https://doi.org/10.1016/j.mrgentox.2018.11.016
https://doi.org/10.1016/j.mrgentox.2018.11.016
Autor:
Kazunori Fujimoto, Kazuyuki Hashimoto, Kazuhiko Mori, Hiroyuki Kishino, Takashi Yamoto, Kyoko Watanabe
Publikováno v:
The Journal of toxicological sciences. 45(6)
The metabolomic profiles of rat primary hepatocytes following treatment with rotenone, FCCP, or (+)-usnic acid were determined using liquid chromatography-mass spectrometry/mass spectrometry and gas chromatography-mass spectrometry. Significant and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558580cca13413c15abad1b5738b823c
https://pubmed.ncbi.nlm.nih.gov/32493876
https://pubmed.ncbi.nlm.nih.gov/32493876
Publikováno v:
The Journal of Toxicological Sciences. 44:145-153
A high incidence of positive results is obtained with in vitro genotoxicity tests, which do not correlate with the in vivo negative results in many cases. To address this issue, the metabolic profile of rat liver 9000 × g supernatant fraction (S9) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d686488b5cbfc9d0e0517a8b0897a4
https://doi.org/10.2131/jts.44.145
https://doi.org/10.2131/jts.44.145
Publikováno v:
The Journal of Toxicological Sciences. 44:701-709
Genotoxicity and carcinogenicity profiles of drugs occasionally vary across species due to species difference in drug metabolic profile. To clarify the effect of species differences in the metabolic profile on micronucleus induction, we conducted an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1740c84efbe952b3bcbd032df8739d8
https://doi.org/10.2131/jts.44.701
https://doi.org/10.2131/jts.44.701
Autor:
Yuki, Kishino, Tomoko, Hasegawa, Shingo, Arakawa, Yukari, Shibaya, Takashi, Yamoto, Kazuhiko, Mori
Publikováno v:
The Journal of toxicological sciences. 44(3)
A high incidence of positive results is obtained with in vitro genotoxicity tests, which do not correlate with the in vivo negative results in many cases. To address this issue, the metabolic profile of rat liver 9000 × g supernatant fraction (S9) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b7084a8cff730b0fd441b7a02439a18
https://pubmed.ncbi.nlm.nih.gov/30842367
https://pubmed.ncbi.nlm.nih.gov/30842367
Autor:
Yoshikazu Nezu, Takashi Yamoto, Mitsuyuki Shirai, Fumitoshi Asai, Hisakuni Obayashi, Naoko Kobayashi
Publikováno v:
The Journal of Toxicological Sciences. 42:385-396
To identify new candidate biomarkers for skeletal muscle toxicity, an unbiased metabolomic analysis was performed in rats treated with two distinct myotoxicants, cerivastatin (CER) and tetramethyl-p-phenylenediamine (TMPD). Skeletal muscle toxicity w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7cd92ab539d120fc74fceee4494a39
https://doi.org/10.2131/jts.42.385
https://doi.org/10.2131/jts.42.385
Autor:
Fumitoshi Asai, Takashi Yamoto, Yoshikazu Nezu, Hisakuni Obayashi, Naoko Kobayashi, Mitsuyuki Shirai
Publikováno v:
The Journal of toxicological sciences. 43(10)
Previously, we have demonstrated the potential of plasma 2-hydroxyglutarate (2HG) as an easily detectable biomarker for skeletal muscle injury in rats. Here, we examined whether plasma 2HG was superior to conventional skeletal muscle damage biomarker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272ea9a90ac54b91f807928b1d2b619e
https://pubmed.ncbi.nlm.nih.gov/30298848
https://pubmed.ncbi.nlm.nih.gov/30298848
Publikováno v:
Drug Metabolism and Pharmacokinetics. 26:399-406
The widely used analgesic-antipyretic drug acetaminophen (APAP) is known to cause serious liver necrosis at high doses in man and experimental animals. For studies of toxic processes, 1H NMR spectroscopy of biofluids allows monitoring of endogenous m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2906d228cf00966b0b537c6e10dead
https://doi.org/10.2133/dmpk.dmpk-11-rg-005
https://doi.org/10.2133/dmpk.dmpk-11-rg-005
Autor:
Sunao Manabe, Naoki Kiyosawa, Shusuke Yamauchi, Noriyo Niino, Kyoko Watanabe, Atsushi Sanbuissho, Yosuke Ando, Kazumi Ito, Takashi Yamoto
Publikováno v:
Archives of Toxicology. 85:1045-1056
Hepatic transcriptome and proteome responses against glutathione depletion were investigated by Affymetrix GeneChip Microarray and 2-dimensional gel electrophoresis (2D-DIGE), followed by MALDI-TOF-MS analysis and utilizing a glutathione-depleted rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d67e3dc2c85e4f6a002a43bb63a418
https://doi.org/10.1007/s00204-010-0632-7
https://doi.org/10.1007/s00204-010-0632-7
Publikováno v:
Chemico-Biological Interactions. 188:404-411
Glutathione plays an important role as not only a scavenger of reactive oxygen species but also in the conjugation or detoxification of electrophilic reactive metabolites, which has been thought to be one of the causes for idiosyncratic drug toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8595cfffea38ddfa6f6c64fddb73fce
https://doi.org/10.1016/j.cbi.2010.09.012
https://doi.org/10.1016/j.cbi.2010.09.012