Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Takashi Yahata"'
Autor:
Abd Aziz Ibrahim, Taku Fujimura, Tomoko Uno, Tomoya Terada, Ken-ichi Hirano, Hiroyuki Hosokawa, Akio Ohta, Toshio Miyata, Kiyoshi Ando, Takashi Yahata
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIncreased levels of plasminogen activator inhibitor-1 (PAI-1) in tumors have been found to correlate with poor clinical outcomes in patients with cancer. Although abundant data support the involvement of PAI-1 in cancer progression, whether
Externí odkaz:
https://doaj.org/article/d02edfa23ac84b4a99017fbbb5525d16
Autor:
Shohei Kawakami, Mitsuyo Tsuma-Kaneko, Masakazu Sawanobori, Tomoko Uno, Yoshihiko Nakamura, Hideyuki Matsuzawa, Rikio Suzuki, Makoto Onizuka, Takashi Yahata, Kazuhito Naka, Kiyoshi Ando, Hiroshi Kawada
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract In this study, we examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marro
Externí odkaz:
https://doaj.org/article/23eeca82d7b742c798169e85b4b7464f
Autor:
Daisuke Harama, Takashi Yahata, Keiko Kagami, Masako Abe, Norie Ando, Shin Kasai, Minori Tamai, Koshi Akahane, Takeshi Inukai, Nobutaka Kiyokawa, Abd Aziz Ibrahim, Kiyoshi Ando, Kanji Sugita
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract The long-term prognosis of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) is still unsatisfactory even after the emergence of tyrosine kinase inhibitors (TKIs) against chimeric BCR-ABL, and this is associated with t
Externí odkaz:
https://doaj.org/article/2156dba5f82d4456a3ea4c71de9a68ce
Autor:
Ken-ichi Hirano, Hiroyuki Hosokawa, Takashi Yahata, Kiyoshi Ando, Masayuki Tanaka, Jin Imai, Masaki Yazawa, Masato Ohtsuka, Naoko Negishi, Sonoko Habu, Takehito Sato, Katsuto Hozumi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T-cell development in the thymus is dependent on Notch signaling induced by the interaction of Notch1, present on immigrant cells, with a Notch ligand, delta-like (Dll) 4, on the thymic epithelial cells. Phylogenetic analysis characterizing the prope
Externí odkaz:
https://doaj.org/article/6e7a20644a1948fc86277519767bc960
Autor:
Nobuo Watanabe, Masako Kidokoro, Makiko Tanaka, Shigeaki Inoue, Tomoatsu Tsuji, Hisako Akatuska, Chisa Okada, Yumi Iida, Yoshinori Okada, Yusuke Suzuki, Takehito Sato, Takashi Yahata, Noriaki Hirayama, Yoshihide Nakagawa, Sadaki Inokuchi
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-22 (2020)
Abstract Background The transmembrane glycoprotein podoplanin (PDPN) is upregulated in some tumors and has gained attention as a malignant tumor biomarker. PDPN molecules have platelet aggregation-stimulating domains and, are therefore, suggested to
Externí odkaz:
https://doaj.org/article/5a1af4a7f9584ec687fe39ffbfbe6e70
Autor:
Jin Imai, Takashi Yahata, Hitoshi Ichikawa, Abd Aziz Ibrahim, Masaki Yazawa, Hideaki Sumiyoshi, Yutaka Inagaki, Masashi Matsushima, Takayoshi Suzuki, Tetsuya Mine, Kiyoshi Ando, Toshio Miyata, Katsuto Hozumi
Publikováno v:
Intestinal Research, Vol 18, Iss 2, Pp 219-228 (2020)
Background/Aims Intestinal fibrosis is a major complication of Crohn’s disease (CD). The profibrotic protein transforming growth factor-β (TGF-β) has been considered to be critical for the induction of the fibrotic program. TGF-β has the ability
Externí odkaz:
https://doaj.org/article/990179d6f86f4070a843a3b057abdb35
Autor:
Ken-ichi Hirano, Hiroyuki Hosokawa, Maria Koizumi, Yusuke Endo, Takashi Yahata, Kiyoshi Ando, Katsuto Hozumi
Publikováno v:
eLife, Vol 10 (2021)
Notch signaling primarily determines T-cell fate. However, the molecular mechanisms underlying the maintenance of T-lineage potential in pre-thymic progenitors remain unclear. Here, we established two murine Ebf1-deficient pro-B cell lines, with and
Externí odkaz:
https://doaj.org/article/0ef8605041b74b7abf09a191f6d51579
Autor:
Takashi Yahata, Abd Aziz Ibrahim, Ken-ichi Hirano, Yukari Muguruma, Kazuhito Naka, Katsuto Hozumi, Douglas E. Vaughan, Toshio Miyata, Kiyoshi Ando
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
Therapeutic strategies that target leukemic stem cells (LSCs) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here, we show that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibil
Externí odkaz:
https://doaj.org/article/33be840ab0fa4143ad05bd208fc116c2
Autor:
Hiromichi Matsushita, Takashi Yahata, Yin Sheng, Yoshihiko Nakamura, Yukari Muguruma, Hideyuki Matsuzawa, Masayuki Tanaka, Hideki Hayashi, Tadayuki Sato, Anar Damdinsuren, Makoto Onizuka, Mamoru Ito, Hayato Miyachi, Pier Paolo Pandolfi, Kiyoshi Ando
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111082 (2014)
Recent advances in cancer biology have revealed that many malignancies possess a hierarchal system, and leukemic stem cells (LSC) or leukemia-initiating cells (LIC) appear to be obligatory for disease progression. Acute promyelocytic leukemia (APL),
Externí odkaz:
https://doaj.org/article/8321de1a09bc4a3fa4ba669156ce9a79
Autor:
Yukari Muguruma, Hiromichi Matsushita, Takashi Yahata, Shizu Yumino, Yumiko Tanaka, Hayato Miyachi, Yoshiaki Ogawa, Hiroshi Kawada, Mamoru Ito, Kiyoshi Ando
Publikováno v:
Haematologica, Vol 96, Iss 4 (2011)
Background To understand how myelodysplastic syndrome cells evolve from normal stem cells and gain competitive advantages over normal hematopoiesis, we established a murine xenograft model harboring bone marrow cells from patients with myelodysplasti
Externí odkaz:
https://doaj.org/article/2578e17e98824a53a4a038756aa51a48