Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Takashi UMEHARA"'
Autor:
Takashi UMEHARA, Marino OGASAHARA, D.M.V. Supun PREMARATHNE, Yuka SASAKAWA, Yasuo SUMIDA, Masayuki SHIMADA
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 3, Pp 202-206 (2024)
Ovarian fibrosis contributes to age-related ovarian dysfunction. In our previous study, we observed ovarian fibrosis in both obese and aging mice with intracellular lipid droplets in the fibrotic ovaries. Although the importance of mitochondria in ov
Externí odkaz:
https://doaj.org/article/c0aa709f0e764b44aa30ac28870be3a3
Autor:
Akari Miwa, Masatoshi Wakamori, Tetsuro Ariyoshi, Yasushi Okada, Mikako Shirouzu, Takashi Umehara, Koki Kamiya
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract To develop artificial cell models that mimic living cells, cell-sized lipid vesicles encapsulating cell-free protein synthesis (CFPS) systems are useful for protein expressions or artificial gene circuits for vesicle–vesicle communications
Externí odkaz:
https://doaj.org/article/e556d5036f8846bba93418939d59267e
Autor:
Nando D. Das, Jen-Chien Chang, Chung-Chau Hon, S. Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, Haruhiko Koseki, Yutaka Kondo, Aki Minoda, Takashi Umehara
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Super-enhancers (SEs), which activate genes involved in cell-type specificity, have mainly been defined as genomic regions with top-ranked enrichment(s) of histone H3 with acetylated K27 (H3K27ac) and/or transcription coactivator(
Externí odkaz:
https://doaj.org/article/5b74b7e87b6c485084dc2c0220e913a3
Autor:
Masaki Kikuchi, Satoshi Morita, Masatoshi Wakamori, Shin Sato, Tomomi Uchikubo-Kamo, Takehiro Suzuki, Naoshi Dohmae, Mikako Shirouzu, Takashi Umehara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Histone acetylation is important for the activation of gene transcription but little is known about its direct read/write mechanisms. Here, we report cryogenic electron microscopy structures in which a p300/CREB-binding protein (CBP) multido
Externí odkaz:
https://doaj.org/article/acaf383597024ad590d456fce9a48fc8
Autor:
Ihshan Akthar, Yejin Kim, Takashi Umehara, Chihiro Kanno, Motoki Sasaki, Mohamed Ali Marey, Mohamed Samy Yousef, Shingo Haneda, Masayuki Shimada, Akio Miyamoto
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
It is known that sperm and seminal plasma (SP) affect uterine immunity. In cattle, artificial insemination enables breeding by depositing frozen and largely diluted sperm with a negligible amount of SP into the uterus. Thus, the present study focused
Externí odkaz:
https://doaj.org/article/42edfaa6c48d42a2b5823995e9ebc606
Autor:
Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
This study describes RK-701, an inhibitor of histone methyltransferases G9a/GLP, as a promising therapeutic candidate for sickle cell disease and a universal role of BGLT3 lncRNA in fetal hemoglobin reactivation by chemical inducers including RK-701.
Externí odkaz:
https://doaj.org/article/854cca959e544001b639a7418e25c89f
Autor:
Atsushi Morimoto, Ryan Rose, Kirsten Smith, Doan ‘Thao’ Dinh, Takashi Umehara, Yasmyn Winstanley, Yoshiharu Morimoto, Darryl Russell, Rebecca Robker
Publikováno v:
Fertility & Reproduction, Vol 05, Iss 04, Pp 323-323 (2023)
Background and Aims: Aging and obesity are associated with female infertility, with mitochondrial dysfunction proposed as an underlying factor; but our understanding of energy metabolism within the ovary remains limited. Method: This study focused on
Externí odkaz:
https://doaj.org/article/19b1cefba8b6488eb8b4fea759ebbc1c
Autor:
Ayako Furukawa, Masatoshi Wakamori, Yasuhiro Arimura, Hideaki Ohtomo, Yasuo Tsunaka, Hitoshi Kurumizaka, Takashi Umehara, Yoshifumi Nishimura
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105408- (2022)
Externí odkaz:
https://doaj.org/article/4c08afbc89814082b417b06881f3110d
Publikováno v:
Reproductive Medicine and Biology, Vol 20, Iss 3, Pp 289-298 (2021)
Abstract Purpose The present study was undertaken to clarify whether bovine sperm could take up fatty acids (FAs) and produce ATP to maintain linear motility. Methods Frozen bovine semen was thawed in media containing either lipid mixture (LM) or FAs
Externí odkaz:
https://doaj.org/article/1e11fe75818d4c979a3e57ab55b16a84
Autor:
Erna Davydova, Tadahiro Shimazu, Maren Kirstin Schuhmacher, Magnus E. Jakobsson, Hanneke L. D. M. Willemen, Tongri Liu, Anders Moen, Angela Y. Y. Ho, Jędrzej Małecki, Lisa Schroer, Rita Pinto, Takehiro Suzuki, Ida A. Grønsberg, Yoshihiro Sohtome, Mai Akakabe, Sara Weirich, Masaki Kikuchi, Jesper V. Olsen, Naoshi Dohmae, Takashi Umehara, Mikiko Sodeoka, Valentina Siino, Michael A. McDonough, Niels Eijkelkamp, Christopher J. Schofield, Albert Jeltsch, Yoichi Shinkai, Pål Ø. Falnes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Only very few enzymes are known to catalyze protein histidine methylation. Here, the authors show that METTL9 is responsible for most 1-methylhistidine modifications in mouse and human proteomes, and characterize METTL9′s substrate specificity and
Externí odkaz:
https://doaj.org/article/f285ea6c5c6e4717b078c180ed9b6cd5