Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Takashi Temma"'
Autor:
Anna Miyazaki, Yasukazu Kanai, Keita Wakamori, Serina Mizuguchi, Mikiya Futatsugi, Fuko Hirano, Naoya Kondo, Takashi Temma
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Background Signal transducer and activator of transcription 3 (STAT3) is a protein that regulates cell proliferation and differentiation, and it is attracting attention as a new index for evaluating cancer pathophysiology, as its activation
Externí odkaz:
https://doaj.org/article/0b59f10667d44a15a9ae84db9aa36405
Publikováno v:
Cancers, Vol 15, Iss 6, p 1862 (2023)
Boron neutron capture therapy (BNCT) is an attractive approach to treating cancers. Currently, only one 10B-labeled boronoagent (Borofalan, BPA) has been approved for clinical BNCT in Japan, and methods for predicting and measuring BNCT efficacy must
Externí odkaz:
https://doaj.org/article/aded391a5e97468386426d9e181bca69
Publikováno v:
Sensors, Vol 22, Iss 19, p 7671 (2022)
The amount and localization of boron-10 atoms delivered into tumor cells determines the therapeutic effect of boron neutron capture therapy (BNCT) and, consequently, efforts have been directed to develop fluorescence sensors to detect intracellular b
Externí odkaz:
https://doaj.org/article/1643b718a2094f93ab9b7fbe02e59e72
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1106 (2022)
Although 4-borono-l-phenylalanine (4-BPA) is currently the only marketed agent available for boron neutron capture therapy (BNCT), its low water solubility raises concerns. In this study, we synthesized 3-borono-l-phenylalanine (3-BPA), a positional
Externí odkaz:
https://doaj.org/article/01b34d0780f84685a0d64e3b210f42ed
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Understanding cerebral oxygen metabolism is of great importance in both clinical diagnosis and animal experiments because oxygen is a fundamental source of brain energy and supports brain functional activities. Since small animals such as rats are wi
Externí odkaz:
https://doaj.org/article/e216544aa56b48cf8b4b86222fa4e1f5
Autor:
Kantaro Nishigori, Takashi Temma, Satoru Onoe, Sotaro Sampei, Ikuo Kimura, Masahiro Ono, Hideo Saji
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94668 (2014)
Fatty acid binding protein 4 (FABP4) is the most well-characterized FABP isoform. FABP4 regulates inflammatory pathways in adipocytes and macrophages and is involved in both inflammatory diseases and tumor formation. FABP4 expression was recently rep
Externí odkaz:
https://doaj.org/article/2e7b7fe7a6cd4fdea6b0a332eab734b0
Autor:
Takashi Temma, Hirofumi Hanaoka, Aki Yonezawa, Naoya Kondo, Kohei Sano, Takeharu Sakamoto, Motoharu Seiki, Masahiro Ono, Hideo Saji
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102180 (2014)
Since matrix metalloproteinase-2 (MMP-2) is an important marker of tumor malignancy, we developed an original drug design strategy, MMP-2 activity dependent anchoring probes (MDAP), for use in MMP-2 activity imaging, and evaluated the usefulness of t
Externí odkaz:
https://doaj.org/article/2c3de7107756466f8485d8cd4e50586f
Publikováno v:
Analytical Sciences. 38:1289-1296
Since the therapeutic effect of boron neutron capture therapy is influenced by the intracellular distribution profile of boronoagents containing
Autor:
Kohei Sano, Yuji Nakamoto, Kaori Togashi, Ayako Kato, Masashi Ueda, Takashi Temma, Yoichi Shimizu, Tsuneo Saga, Nobuyuki Hayakawa, Takayoshi Ishimori
Publikováno v:
Annals of Nuclear Medicine. 35:397-405
Tumor-induced osteomalacia (TIO) is caused by typically small tumors that secrete fibroblast growth factor 23 (FGF23). As tumor resection is the only effective treatment for TIO, it is important to detect the culprit tumor. We aimed to assess the uti
Autor:
Yoshihiro Kushida, Masahiro Tsuji, Toshihiko Suzuki, Masahiro Hayakawa, Yukako Iitani, Shigeyoshi Saito, Yoshiyuki Takahashi, Mari Dezawa, Kenji Imai, Cesar V. Borlongan, Shinobu Shimizu, Hideki Hida, Masaaki Mizuno, Takashi Temma, Shohei Wakao, Hidehiro Iida, Kazuto Ueda, Yoshiaki Sato
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Perinatal hypoxic ischemic encephalopathy (HIE) results in serious neurological dysfunction and mortality. Clinical trials of multilineage-differentiating stress enduring cells (Muse cells) have commenced in stroke using intravenous delivery of donor