Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Takashi Sohda"'
Publikováno v:
YAKUGAKU ZASSHI. 122:909-918
Insulin resistance is a characteristic feature of type II diabetes as well as obesity. This insulin resistant state at the peripheral tissue level causes impaired glucose utilization, leading to hyperglycemia. Studies of antidiabetic agents by Takeda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f9ca01b8585a13b1fa3a94d7e45b544
https://doi.org/10.1248/yakushi.122.909
https://doi.org/10.1248/yakushi.122.909
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:1349-1357
A novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the 2,4-thiazolidinedione moiety. These compounds were evaluated for glucose and lipid lowering effects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60aac99ec863637aacf698c3c048100f
https://doi.org/10.1248/cpb.50.1349
https://doi.org/10.1248/cpb.50.1349
Publikováno v:
Journal of Pharmaceutical Sciences. 90:2121-2130
The benzothiepin derivative (2R,4S)‐(‐)‐N‐(4‐diethoxyphosphorylmethylphenyl)‐1,2,4,5‐tetrahydro‐4‐methyl‐7,8‐methylenedioxy‐5‐oxo‐3‐benzothiepin‐2‐carboxamide (TAK‐778) is a potent bone formation stimulant. A susta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4259e3018dc37aeb2fd5eb656b2374
https://doi.org/10.1002/jps.1163
https://doi.org/10.1002/jps.1163
Autor:
Tetsuo Hoshino, Hirofumi Nagai, Haruhiko Makino, Yasuaki Ogawa, Hiroya Muranishi, Kazuhiro Saito, Takashi Sohda, Kohei Notoya
Publikováno v:
Journal of Biomedical Materials Research. 51:299-306
The feasibility of using microcapsules containing a bone formation stimulant, (2R,4S)-(−)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide (TAK-778) to enhance fracture repair wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498bcb4ee97021a6ad14b9e7c8433675
https://doi.org/10.1002/1097-4636(20000905)51:3<299::aid-jbm2>3.0.co
https://doi.org/10.1002/1097-4636(20000905)51:3<299::aid-jbm2>3.0.co
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:1130-1134
The metabolites of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmeth yl)quinoline -3-carboxylate (1, TAK-603), which is under clinical evaluation as a new type of disease-modifying antirheumatic drug (DMARD), were prepared to conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c863663b974ec0e3645b6f56eb0ad95
https://doi.org/10.1248/cpb.46.1130
https://doi.org/10.1248/cpb.46.1130
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 613:43-49
An on-line urine clean-up system was developed for the simultaneous determination of free and total pyridinoline, hydroxylysyl-pyridinoline (HP) and lysylpyridinoline (LP) by high-performance liquid chromatography (HPLC) using a column-switching tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2449ea35d31ee8c4fb9cb122a33c5d
https://doi.org/10.1016/0378-4347(93)80195-a
https://doi.org/10.1016/0378-4347(93)80195-a
Autor:
Haruhiko Makino, Noriaki Kawamura, Shigehisa Taketomi, Yoshikazu Ohta, Takashi Sohda, Atsuo Baba
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a78e0b6fa1691f54d69edfc6181dd969
https://doi.org/10.1002/chin.199716185
https://doi.org/10.1002/chin.199716185
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9013fada4a4dbdd3ae0e94a4279b05
https://doi.org/10.1002/chin.199852310
https://doi.org/10.1002/chin.199852310
Autor:
Atsushi Nishimura, Yukio Fujisawa, Takashi Sohda, Tsuneo Yasuma, Satoru Oi, Toshiyuki Nomura, Nobuo Choh, Naoki Furuyama
Publikováno v:
ChemInform. 30
Cathepsin L, a lysosomal cysteine protease, is secreted by osteoclasts and participates in bone collagen degradation. In a search for cathepsin L inhibitors as antiosteoporotic agents, a series of ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a5ebc4c82ecfbae17002f56f976e5d3
https://doi.org/10.1002/chin.199912205
https://doi.org/10.1002/chin.199912205
Autor:
Atsuo Baba, Tsuneo Oda, Takashi Sohda, Haruhiko Makino, Kohei Notoya, Atsushi Nishimura, Shigehisa Taketomi
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::297c45e3c5e490abc08c931007ae77ea
https://doi.org/10.1002/chin.199942153
https://doi.org/10.1002/chin.199942153