Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Takashi Shingu"'
Autor:
Fatma Betul Aksoy Yasar, Takashi Shingu, Daniel B. Zamler, Mohammad Fayyad Zaman, Derek Lin Chien, Qiang Zhang, Jiangong Ren, Jian Hu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Glioblastoma (GBM) is a high-grade, aggressive brain tumor with dismal median survival time of 15 months. Chromosome 6q (Ch6q) is a hotspot of genomic alterations, which is commonly deleted or hyper-methylated in GBM. Two neighboring genes in this re
Externí odkaz:
https://doaj.org/article/bc98eecd8e994e478679c277d4c85a2a
Autor:
Daniel B. Zamler, Takashi Shingu, Laura M. Kahn, Kristin Huntoon, Cynthia Kassab, Martina Ott, Katarzyna Tomczak, Jintan Liu, Yating Li, Ivy Lai, Rocio Zorilla-Veloz, Cassian Yee, Kunal Rai, Betty Y.S. Kim, Stephanie S. Watowich, Amy B. Heimberger, Giulio F. Draetta, Jian Hu
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Novel therapeutic strategies targeting glioblastoma (GBM) often fail in the clinic, partly because preclinical models in which hypotheses are being tested do not recapitulate human disease. To address this challenge, we took advantage of our previous
Externí odkaz:
https://doaj.org/article/f2d1aec989ba484691463ec5f1531b0b
Autor:
Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zeng, Shaobo Wang, Xin Zhou, Hongtao Li, Qiang Zhang, Qinling Mo, Jiafu Long, Fei Lan, Yiwen Chen, Jian Hu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Eye lens cells are highly enriched in cholesterol that sustains lens transparency, and disruption of cholesterol biosynthesis leads to cataracts. The authors show that cholesterol biosynthesis regulated by Qki is essential for maintenance of membrane
Externí odkaz:
https://doaj.org/article/d277186ce32543ea986dbee11a0ed576
Autor:
Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu
Publikováno v:
eLife, Vol 10 (2021)
Myelination depends on timely, precise control of oligodendrocyte differentiation and myelinogenesis. Cholesterol is the most abundant component of myelin and essential for myelin membrane assembly in the central nervous system. However, the underlyi
Externí odkaz:
https://doaj.org/article/e845eaeb64b84ef2807b2cdb227342fc
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in re
Externí odkaz:
https://doaj.org/article/567eed3baa0b4b0988dff002eda6616d
Autor:
Chao-Hsien Chen, Renee L Chin, Genevieve P Hartley, Spencer T Lea, Brian J Engel, Cheng-En Hsieh, Rishika Prasad, Jason Roszik, Takashi Shingu, Gregory A Lizee, Amy B Heimberger, Steven W Millward, Jian Hu, David S Hong, Michael A Curran
Publikováno v:
Neuro-Oncology.
Background The lack of murine glioblastoma models that mimic the immunobiology of human disease has impeded basic and translational immunology research. We, therefore, developed murine glioblastoma stem cell lines derived from Nestin-CreERT2 QkL/L; T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2796021029fdc38e5f05d5a834911648
https://doi.org/10.1093/neuonc/noad025
https://doi.org/10.1093/neuonc/noad025
Autor:
Yunfei Wang, Jiafu Long, Xin Zhou, Chenxi He, Hao Zhou, Jian Hu, Shaobo Wang, Fei Lan, Qiang Zhang, Yanjun Wei, Takashi Shingu, Qinling Mo, Ailiang Zeng, Hongtao Li, Seula Shin, Yiwen Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Defective cholesterol biosynthesis in eye lens cells is often associated with cataracts; however, how genes involved in cholesterol biosynthesis are regulated in lens cells remains unclear. Here, we show that Quaking (Qki) is required for the transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f619ede8c81c26edebd97128e64576ef
https://doaj.org/article/d277186ce32543ea986dbee11a0ed576
https://doaj.org/article/d277186ce32543ea986dbee11a0ed576
Autor:
Jiangong Ren, Feng Zhou, Qianghu Wang, Visweswaran Ravikumar, Yunfei Wang, Chythra R. Chandregowda, Sharon R. Stevens, Arvind Rao, Yiwen Chen, Matthew N. Rasband, Liang Yuan, Chenxi He, Benjamin M. Segal, Hongwu Zheng, Daniel Zamler, Congxin Dai, Takashi Shingu, Jian Hu, Amy B. Heimberger, Fei Lan, Xin Zhou
Publikováno v:
J Clin Invest
Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669c2a95e7face4e932c0daf2a9bfcf4
https://doi.org/10.1172/jci131800
https://doi.org/10.1172/jci131800
Publikováno v:
Neuro-Oncology. 24:vii278-vii278
An average GBM has roughly 30% infiltration of myeloid cells, the highest reported case at 70% infiltration, with some variation dependent on subtype. When we consider this fact in combination with the advent and success of immunotherapies in similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f4286c42516910b424843a4942c3cbb
https://doi.org/10.1093/neuonc/noac209.1077
https://doi.org/10.1093/neuonc/noac209.1077
Autor:
Rocío I Zorrilla-Veloz, Fei Lan, Jian Hu, Takashi Shingu, Matthew N. Rasband, Xin Zhou, Qiang Zhang, Liang Yuan, Congxin Dai, Chenxi He, Yunfei Wang, Yiwen Chen, Jiangong Ren, Seula Shin
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Myelination depends on timely, precise control of oligodendrocyte differentiation and myelinogenesis. Cholesterol is the most abundant component of myelin and essential for myelin membrane assembly in the central nervous system. However, the underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898df270de037c418f4ef7cbf43376e2
https://doi.org/10.7554/elife.60467
https://doi.org/10.7554/elife.60467