Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Takashi Orimo"'
Autor:
Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki, Hiroyuki Mishima, Akira Kinoshita, Tsunehiro Mizushima, Satoru Hamada, Kazuya Hamada, Norio Kawamoto, Saori Kadowaki, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Miyuki Tsumura, Yusuke Yamashita, Shinobu Tamura, Takashi Orimo, Toshiya Ozasa, Takashi Kato, Izumi Sasaki, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Yutaka Inaba, Kayo Kunimoto, Satoshi Okada, Takeshi Taketani, Koichi Nakanishi, Shigeo Murata, Koh-ichiro Yoshiura, Tsuneyasu Kaisho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Genetic variants of proteasome subunit genes have been shown to associate with perturbed immune function. Here authors show that a heterozygous missense variant of the immunoproteasome subunit β-type 9 causes an autoinflammatory/immune deficiency sy
Externí odkaz:
https://doaj.org/article/bc153bd94dab48289d8e89f5cfa52002
Augmentation of Stimulator of Interferon Genes–Induced Type I Interferon Production in COPA Syndrome
Autor:
Takashi Orimo, Junko Takita, Hidenori Nakamura, Masaki Yamamoto, Kyoichi Isono, Toshiaki Miyamoto, Takashi Kato, Kohei Murakami, Tsuneyasu Kaisho, Tadashi Matsubayashi, Yuri Fukuda-Ohta, Hiroaki Hemmi, Yoshiro Otsuki, Yoshitaka Honda, Saki Takayama, Kazushi Izawa, Izumi Sasaki, Takahiro Yasumi, Ryuta Nishikomori
Publikováno v:
Arthritis & Rheumatology. 73:2105-2115
OBJECTIVE Coatomer subunit alpha (COPA) syndrome, also known as autoinflammatory interstitial lung, joint, and kidney disease, is caused by heterozygous mutations in COPA. We identified a novel COPA variant in 4 patients in one family. We undertook t
Autor:
Keiji Hayata, Mikihito Nakamori, Tomokazu Ohta, Yuji Kitahata, Masahiro Katsuda, Hiroki Yamaue, Hiroaki Hemmi, Izumi Sasaki, Masaki Nakamura, Atsushi Miyamoto, Kenji Matsuda, Takashi Orimo, Soichiro Okura, Toshiyasu Ojima, Yuri Fukuda-Ohta, Yuki Mizumoto, Koji Tamada, Masanaka Sugiyama, Motoki Miyazawa, Tsuneyasu Kaisho
Publikováno v:
British Journal of Cancer
BackgroundCancer peptide vaccines show only marginal effects against cancers. Immune checkpoint inhibitors (ICIs) show significant curative effects in certain types of cancers, but the response rate is still limited. In this study, we aim to improve
Autor:
Takashi Orimo, Yumi Kuninaka, Mika Mizoguchi, Naoyuki Iwahashi, Izumi Sasaki, Tamaki Yahata, Kazuhiko Ino, Toshikazu Kondo, Yuko Ishida, Hiroaki Hemmi, Mizuho Nosaka, Yuri Fukuda-Ohta, Saori Toujima, Akihiko Kimura, Tsuneyasu Kaisho, Tomoko Noguchi
Publikováno v:
Cancer Science
Programmed cell death ligand 1 (PD‐L1) on tumor cells suppresses anti‐tumor immunity and has an unfavorable prognostic impact in ovarian cancer patients. We herein report the pathophysiological and therapeutic impacts of PD‐L1 disruption in ova
Autor:
Ken Ishii, Kiyoshi Takeda, Kensuke Miyake, Takashi Orimo, Yuri Fukuda-Ohta, Kei-ichi Katayama, Izumi Sasaki, Mariko Kitauchi, Yayoi Sato, Mio Morinaka, Toshiya Ozasa, Tsuneyasu Kaisho, Takashi Tanaka, Tomokazu Ohta, Katsuaki Hoshino, Takashi Satoh, Masahiro Yamamoto, Koichi Furukawa, Takako Yamaguchi, Etsushi Kuroda, Hiroaki Hemmi, Shinji Fukuda
Publikováno v:
International Immunology
Cholera toxin B (CTB) is a subunit of cholera toxin, a bacterial enterotoxin secreted by Vibrio cholerae and also functions as an immune adjuvant. However, it remains unclear how CTB activates immune cells. We here evaluated whether or how CTB induce
Autor:
Yusuke Yamashita, Kazushi Izawa, Satoru Hamada, Yoshitaka Honda, Kazuya Hamada, Noriko Kinjo, Takashi Orimo, Wakaki-Nishiyama N, Takashi Kato, Ryuta Nishikomori, Koichi Nakanishi, Akira Kinoshita, Tsunehiro Mizushima, Jun Hamazaki, Saori Kadowaki, Hidenori Ohnishi, Satoshi Okada, Yutaka Inaba, Tsuneyasu Kaisho, Izumi Sasaki, Norio Kawamoto, Toshiya Ozasa, Yuri Fukuda-Ohta, Miyuki Tsumura, Nobuo Kanazawa, Shigeo Murata, Kayo Kunimoto, Shinobu Tamura, Koh-ichiro Yoshiura, Hiroyuki Mishima, Hiroaki Hemmi, Takeshi Taketani
BACKGROUNDDefective proteasome activities due to genetic mutations lead to an autoinflammatory disease, termed as proteasome-associated autoinflammatory syndromes (PRAAS). In PRAAS relapsing inflammations and progressive wasting are common, but immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd5842997c9d94ba01e5b6d903f096d
https://doi.org/10.1101/2021.02.01.21250077
https://doi.org/10.1101/2021.02.01.21250077
Autor:
Ken Ishii, Izumi Sasaki, Masanaka Sugiyama, Yuri Fukuda, Takashi Orimo, Tsuneyasu Kaisho, Florent Ginhoux, Soichiro Okura, Hiroaki Hemmi, Katsuaki Hoshino, Chihiro Yamazaki, Tomokazu Ohta
Publikováno v:
Scientific Reports
Intestinal immune homeostasis requires dynamic crosstalk between innate and adaptive immune cells. Dendritic cells (DCs) exist as multiple phenotypically and functionally distinct sub-populations within tissues, where they initiate immune responses a