Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Takashi Obama"'
Autor:
Hiroyuki Itabe, Takashi Obama
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5747 (2023)
A high concentration of low-density lipoproteins (LDLs) in circulation has been well-known as a major risk factor for cardiovascular diseases. The presence of oxidized LDLs (oxLDLs) in atherosclerotic lesions and circulation was demonstrated using an
Externí odkaz:
https://doaj.org/article/b4445ce59c424c6fa1aeb2449a59288f
Autor:
Naoko Sawada, Takashi Obama, Shinji Koba, Takashi Takaki, Sanju Iwamoto, Toshihiro Aiuchi, Rina Kato, Masaki Kikuchi, Yuji Hamazaki, Hiroyuki Itabe
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 816-829 (2020)
Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, dete
Externí odkaz:
https://doaj.org/article/ab84766f6d904cca9467842094fec8c2
Publikováno v:
Biological Research, Vol 53, Iss 1, Pp 1-10 (2020)
Abstract Background The pellicle, the acellular organic material deposited on the surface of tooth enamel, has been thought to be derived from saliva. In this study, protein compositions of the pellicle, gingival crevicular fluid, and saliva collecte
Externí odkaz:
https://doaj.org/article/3d09217028934b429f51713b9c433590
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13992 (2022)
Neutrophil extracellular traps (NETs) are found in patients with various diseases, including cardiovascular diseases. We previously reported that copper-oxidized low-density lipoprotein (oxLDL) promotes NET formation of neutrophils, and that the resu
Externí odkaz:
https://doaj.org/article/060f2077804947d2886e4d9801000d85
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6366 (2022)
Lipid droplets (LDs) are intracellular organelles that are ubiquitous in many types of cells. The LD core consists of triacylglycerols (TGs) surrounded by a phospholipid monolayer and surface proteins such as perilipin 2 (PLIN2). Although TGs accumul
Externí odkaz:
https://doaj.org/article/09d87a35f20b46f3a1a23a85b025924b
Autor:
Shunji Kato, Yusuke Osuka, Saoussane Khalifa, Takashi Obama, Hiroyuki Itabe, Kiyotaka Nakagawa
Publikováno v:
Antioxidants, Vol 10, Iss 10, p 1598 (2021)
The continuous formation and accumulation of oxidized lipids (e.g., lipid hydroperoxides (LOOH)) which are present even in plasma lipoproteins of healthy subjects, are ultimately considered to be linked to various diseases. Because lipid peroxidation
Externí odkaz:
https://doaj.org/article/dc316f64ce744ec08a39a261d0a6cb53
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 655 (2021)
Oxidative modification of lipoproteins is implicated in the occurrence and development of atherosclerotic lesions. Earlier studies have elucidated on the mechanisms of foam cell formation and lipid accumulation in these lesions, which is mediated by
Externí odkaz:
https://doaj.org/article/24fbfb2c453440afa9edaa8bf3347be4
Autor:
Takashi Obama, Hitomi Ohinata, Takashi Takaki, Sanju Iwamoto, Naoko Sawada, Toshihiro Aiuchi, Rina Kato, Hiroyuki Itabe
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The function of oxidatively modified low-density lipoprotein (oxLDL) in the progression of cardiovascular diseases has been extensively investigated and well-characterized with regards to the activation of multiple cellular responses in macrophages a
Externí odkaz:
https://doaj.org/article/6d31fc7fb5724d3e909123d776131799
Autor:
Takashi Obama, Hiroyuki Itabe
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8312 (2020)
Neutrophil extracellular traps (NETs) significantly contribute to various pathophysiological conditions, including cardiovascular diseases. NET formation in the vasculature exhibits inflammatory and thrombogenic activities on the endothelium. NETs ar
Externí odkaz:
https://doaj.org/article/6457475971ea42e5b2a5b125356c4e5c
Autor:
Naoko Sawada, Takashi Obama, Mirei Mizuno, Kiyoshi Fukuhara, Sanju Iwamoto, Toshihiro Aiuchi, Tomohiko Makiyama, Hiroyuki Itabe
Publikováno v:
Antioxidants, Vol 9, Iss 11, p 1045 (2020)
Oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL), known as risk factors for cardiovascular disease, have been observed in plasma and atheromatous plaques. In a previous study, the content of oxidized phosphatidyl
Externí odkaz:
https://doaj.org/article/461cbb6d5a0541fb97dbfb313a8ac042