Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Takashi OHAMA"'
Autor:
Daisuke Fujimori, Jun Kinoshita, Takahisa Yamaguchi, Yusuke Nakamura, Katsuya Gunjigake, Takashi Ohama, Koichi Sato, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Tetsuo Ohta, Sachio Fushida
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Peritoneal metastasis (PM) in gastric cancer (GC) is characterized by diffusely infiltrating and proliferating cancer cells accompanied by extensive stromal fibrosis in the peritoneal space. The prognosis of GC with PM is still po
Externí odkaz:
https://doaj.org/article/f44b2db7eac8404289dae8a3b34f174d
Autor:
Ryotaro Yabe, Shunya Tsuji, Satoru Mochida, Tsuyoshi Ikehara, Tatsuya Usui, Takashi Ohama, Koichi Sato
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1486-1496 (2018)
Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme. Accumulating evidence links PP2Ac methylation to diseases, including cancer
Externí odkaz:
https://doaj.org/article/aa84b8c027ea43db99e5813fce983440
Autor:
Satoru Kake, Shunya Tsuji, Shuhei Enjoji, Sayaka Hanasaki, Hiroshi Hayase, Ryotaro Yabe, Yuiko Tanaka, Takayuki Nakagawa, Hao-Ping Liu, Shih-Chieh Chang, Tatsuya Usui, Takashi Ohama, Koichi Sato
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Canine mammary tumor is the most common neoplasm in female dogs, and it has generated considerable attention as a translational model for human breast cancer. Ser/Thr protein phosphatase 2A (PP2A) plays a critical role as a tumor suppressor,
Externí odkaz:
https://doaj.org/article/9d3996734a2e4ea98d3f019b4c72c5de
Autor:
Koji Umata, Yusuke Sakai, Shunta Ikeda, Shunya Tsuji, Hideyoshi Kawasaki, Takashi Ohama, Koichi Sato
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222845 (2019)
SET (also called I2PP2A and TIF-1) is a multi-functional protein that regulates a variety of cell signaling including nucleosome assembly, histone binding, and tumorigenesis. Elevated SET protein levels are observed in various human tumors, and are c
Externí odkaz:
https://doaj.org/article/589d4130bb0f4663a79ddf39e092ece5
Autor:
Tatsuya Usui, Masashi Sakurai, Shuhei Enjoji, Hideyoshi Kawasaki, Koji Umata, Takashi Ohama, Nobuyuki Fujiwara, Ryotaro Yabe, Shunya Tsuji, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Tumor microenvironment has been implicated in tumor development and progression. As a three-dimensional tumor microenvironment model, air liquid interface (ALI) organoid culture from oncogene transgenic mouse gastrointestinal tissues was recently pro
Externí odkaz:
https://doaj.org/article/fc8bb372c4704bf9b693b80671eeaa11
Autor:
Tatsuya Usui, Masashi Sakurai, Koji Umata, Mohamed Elbadawy, Takashi Ohama, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato, Masahiro Kaneda, Kazuaki Sasaki
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1098 (2018)
Colorectal cancer is one of the most common causes of cancer death worldwide. In patients with metastatic colorectal cancer, combination treatment with several anti-cancer drugs is employed and improves overall survival in some patients. Nevertheless
Externí odkaz:
https://doaj.org/article/732fc60fef534435926d0d5b42a064c4
Autor:
Ryotaro Yabe, Akane Miura, Tatsuya Usui, Ingrid Mudrak, Egon Ogris, Takashi Ohama, Koichi Sato
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145226 (2015)
Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways. Protein phosphatase methyl esterase (PME-1) catalyzes specifically the d
Externí odkaz:
https://doaj.org/article/b9e1f577414e4c8a9b168a027e3190a8
Autor:
Sana Ando, Masashi Sakurai, Shusaku Shibutani, Nobuyuki Kimura, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Ryotaro Yabe, Takashi Ohama, Koichi Sato
Publikováno v:
The Journal of Biochemistry. 173:435-445
The abnormal activity of PP2A, a dominant member of type 2A serine/threonine protein phosphatase, has been implicated in the development of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). PP2A is a holoenzyme, and protein methylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cbf9500db5e8348d22fd2230b76d7af
https://doi.org/10.1093/jb/mvad006
https://doi.org/10.1093/jb/mvad006
Publikováno v:
Journal of Veterinary Medical Science; 2023, Vol. 85 Issue 12, p1319-1323, 5p
Autor:
Koichi Sato, Takashi Ohama, Tatsuya Usui, Yoshitaka Hippo, Tetsuya Matsuura, Michael P. Vitek, Masanobu Oshima, Hiroko Oshima, Hiroaki Nagano, Shoichi Hazama, Shigefumi Yoshino, Hiroko Takenouchi, Yusuke Sakai, Masashi Sakurai, Hideyoshi Kawasaki, Kazuhiro Yoshimura, Shunya Tsuji, Ryotaro Yabe, Shuhei Enjoji
Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related deaths worldwide. Chemotherapies against gastric cancer often fail, with cancer recurrence due potentially to the persistence of cancer stem cells. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a864b489e0b4324020de729a78cd2f2
https://doi.org/10.1158/1541-7786.c.6540399.v1
https://doi.org/10.1158/1541-7786.c.6540399.v1
