Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Takashi Nishigaki"'
Publikováno v:
Journal of Veterinary Medical Science. 62:499-504
The inhibitory activities of various 8-difluoromethoxy-4-quinolone derivatives against feline immunodeficiency virus (FIV) replication in the chronically infected cell line P-CrFK were investigated. Certain derivatives were found to inhibit FIV produ
Autor:
Masakatsu Kaneko, Toshinori Agatsuma, Koji Abe, Takashi Nishigaki, Rika Koga, Toshiyuki Kosaka, Junko Sone, Makoto Koizumi, Satoshi Kimura, Hitoshi Hotoda, Hidehiko Furukawa, Toshinori Sankyo Bio-Sc Ohmine, Kenji Momota, Shinya Tsutsumi, Kaoru Shimada
Publikováno v:
Journal of Medicinal Chemistry. 41:3655-3663
A series of hexadeoxyribonucleotides (6-mers), d(TGGGAG), substituted with a variety of aromatic groups at the 5'-end were synthesized and tested for anti-human immunodeficiency virus type 1 (HIV-1) activity. While unmodified d(TGGGAG) (31) had no an
Autor:
Ryuichi Yagi, Yuji Ozawa, Yuichiro Yabe, Takashi Watanabe, Takahiro Shibayama, Aikichi Iwamoto, Tamayo Nitta, Eiji Takashiro, Akihiko Nakagawa, Shuichi Miyamoto, Atsushi Kasuya, Takashi Nishigaki
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:595-604
The structure-activity relationship of HIV-1 protease (HIV-1 PR) inhibitors containing AHPBA (3-amino-2-hydroxy-4-phenylbutanoic acid) is discussed. In order to solve the problem of poor oral bioavailability, small-sized dipeptide HIV-1 protease inhi
Autor:
Hitoshi Hotoda, Makoto Koizumi, Toshinori Ohmine, Hidehiko Furukawa, Takashi Nishigaki, Koji Abe, Toshiyuki Kosaka, Shinya Tsutsumi, Junko Sone, Masakatsu Kaneko, Satoshi Kimura, Kaoru Shimada
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 17:243-252
Deoxyribose-moieties of modified hexadeoxyribonucleotide 1, which exhibits anti-HIV-1 activity, were partially replaced with glycerol-moieties. Compound 7 with two glycerylguanines at its 3′-end showed more potent anti-HIV-1 activity and more stabi
Autor:
Shinichi Oka, Yuji Ozawa, Masakatsu Kaneko, Takashi Nishigaki, Ryuichi Yagi, Satoshi Kimura, Yasuo Komatsu, Makoto Koizumi, Eiko Ohtsuka, Aikichi Iwamoto
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 17:207-218
Three ribozymes, a hairpin ribozyme (HR112) and two hammerhead ribozymes (RZ115 and RZ119) containing a 5′C(UUCG)G3′ loop were designed to cleave the U5 region in the long terminal repeat (LTR) of HIV-1 RNA. The t½ values of chemically synthesiz
Autor:
Koji Abe, Toshinori Ohmine, Takashi Nishigaki, Masakatsu Kaneko, Hidehiko Furukawa, Toshiyuki Kosaka, Toshinori Agatsuma, Makoto Koizumi, Satoshi Kimura, Junko Sone, Hitoshi Hotoda, Rika Koga, Kenji Momota, Shinya Tsutsumi, Kaoru Shimada
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:2235-2243
We have determined that hexadeoxyribonucleotides (5′TGGGAG3′), with modified aromatic groups such as a trityl group at the 5′-end, have anti-HIV-1 activity in vitro. The 6-mer bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5′-end had
Autor:
Shuichi Miyamoto, Takashi Nishigaki, Ryuichi Yagi, Hiroshi Handa, Yasuko Ishikawa, Tomoaki Komai, Atsushi Kasuya, Hisayo Suzuki-Sunagawa
Publikováno v:
Biochemical and Biophysical Research Communications. 230:557-561
In cell-free proteolytic processing using recombinant HIV-1 protease and Gag precursor polypeptide, certain simple oxim derivatives containing halogenomethylketone and phenyl moieties displayed HIV-1 protease inhibitory activity. Their Ki values rang
Autor:
Takashi Nishigaki, Ryuichi Yagi, Hiroshi Mohri, Hiroshi Handa, Hisayo Suzuki-Sunagawa, Mitsuya Sakurai, Kaoru Shimada, Higashida Susumu, Shinichi Oka, Tomoaki Komai, Akira Yasuoka, Satoshi Kimura, Yuichiro Yabe, Machiko Sugano
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:175-180
In a series of compounds containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), a transitionstate mimetic, R-87366:(2S,3S)-3-[N-(quinoxaline-2-carbonyl)-L-asparaginyl]amino- 2-hydroxy-4-phenylbutanoyl-L-proline tert-butylamide, was found
Autor:
Rika Koga, Takeshi Kinoshita, Kaoru Shimada, Makoto Koizumi, Toshinori Ohmine, Takashi Nishigaki, Masakatsu Kaneko, Hitoshi Hotoda, Hidehiko Furukawa, Satoshi Kimura, Kenji Momota
Publikováno v:
Nucleosides and Nucleotides. 15:531-538
Hexadeoxyribonucleotides (6-mers) having a 5′-TGGGAG-3′ sequence bearing hydrophobic substituents at their 5′-ends via phosphodiester linkages were prepared and evaluated for anti-HIV-1 activity in vitro. Some of these modified 6-mers showed we
Autor:
Tetsushi Katsube, Hiroto Kashiwase, Kaoru Shimada, Tomoaki Komai, Masahiko Hagihara, Tomio Kimura, Takashi Nishigaki, Kenji Momota, Toshinori Ohmine, Satoshi Kimura
Publikováno v:
ChemInform. 31
Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the comp