Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Takashi Morisaki"'
Autor:
PingShan Zhong, Kohei Nakata, Koki Oyama, Nobuhiro Higashijima, Akiko Sagara, Satomi Date, HaiZhen Luo, Masataka Hayashi, Akihiro Kubo, ChenYi Wu, Shan He, Takeo Yamamoto, Kazuhiro Koikawa, Chika Iwamoto, Toshiya Abe, Naoki Ikenaga, Kenoki Ohuchida, Takashi Morisaki, Yoshinao Oda, Keiji Kuba, Masafumi Nakamura
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)
Abstract Background Although immune checkpoint blockade (ICB) therapy has proven to be extremely effective at managing certain cancers, its efficacy in treating pancreatic ductal adenocarcinoma (PDAC) has been limited. Therefore, enhancing the effect
Externí odkaz:
https://doaj.org/article/435f4cebeaec4b2e9e2df24a63879fd4
Autor:
Shinji Morisaki, Hideya Onishi, Takafumi Morisaki, Makoto Kubo, Masayo Umebayashi, Hiroto Tanaka, Norihiro Koya, Shinichiro Nakagawa, Kenta Tsujimura, Sachiko Yoshimura, Poh Yin Yew, Kazuma Kiyotani, Yusuke Nakamura, Masafumi Nakamura, Takanari Kitazono, Takashi Morisaki
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Neoantigens/ are tumor-specific antigens that evade central immune tolerance mechanisms in the thymus. Long-term tumor-specific cytotoxic T lymphocyte activity maintenance requires class II antigen-reactive CD4+ T cells. We had previously shown that
Externí odkaz:
https://doaj.org/article/8a24b0348b3c46f88fc706dfa5b638e0
Autor:
Sho Okuda, Kenoki Ohuchida, Shoichi Nakamura, Chikanori Tsutsumi, Kyoko Hisano, Yuki Mochida, Jun Kawata, Yoshiki Ohtsubo, Tomohiko Shinkawa, Chika Iwamoto, Nobuhiro Torata, Yusuke Mizuuchi, Koji Shindo, Taiki Moriyama, Kohei Nakata, Takehiro Torisu, Takashi Morisaki, Takanari Kitazono, Yoshinao Oda, Masafumi Nakamura
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106480- (2023)
Summary: Although chemotherapy has been an essential treatment for cancer, the development of immune checkpoint blockade therapy was revolutionary, and a comprehensive understanding of the immunological tumor microenvironment (TME) has become crucial
Externí odkaz:
https://doaj.org/article/a31b166674cc471891eaf4bb6406e9ce
Autor:
Shoichi Nakamura, Kenoki Ohuchida, Yoshiki Ohtsubo, Yutaka Yamada, Chikanori Tsutsumi, Sho Okuda, Kyoko Hisano, Yuki Mochida, Tomohiko Shinkawa, Chika Iwamoto, Nobuhiro Torata, Yusuke Mizuuchi, Koji Shindo, Kohei Nakata, Taiki Moriyama, Takehiro Torisu, Eishi Nagai, Takashi Morisaki, Takanari Kitazono, Yoshinao Oda, Masafumi Nakamura
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Background Tumour immune microenvironment is related with carcinogenesis and efficacy of immunotherapy. B cells play major roles in humoral immunity, but detailed functions of tumour‐infiltrating B lymphocytes (TIL‐Bs) are unknown. There
Externí odkaz:
https://doaj.org/article/2eb5651f2fdf491390cb52bc3aa6a53b
Autor:
Takafumi Morisaki, Makoto Kubo, Masayo Umebayashi, Poh Yin Yew, Sachiko Yoshimura, Jae-Hyun Park, Kazuma Kiyotani, Masaya Kai, Mai Yamada, Yoshinao Oda, Yusuke Nakamura, Takashi Morisaki, Masafumi Nakamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Neoantigens are tumour-specific antigens that arise from non-synonymous mutations in tumour cells. However, their effect on immune responses in the tumour microenvironment remains unclear in breast cancer. We performed whole exome and RNA se
Externí odkaz:
https://doaj.org/article/2c8160b2daa6447d8caac1e64206aa46
Autor:
Satoko Koga, Hideya Onishi, Shogo Masuda, Akiko Fujimura, Shu Ichimiya, Kazunori Nakayama, Akira Imaizumi, Kenichi Nishiyama, Masayuki Kojima, Kei Miyoshi, Katsuya Nakamura, Masayo Umebayashi, Takashi Morisaki, Masafumi Nakamurab
Publikováno v:
Translational Oncology, Vol 17, Iss , Pp 101344- (2022)
Externí odkaz:
https://doaj.org/article/c8358138816e4f5e92ea2ab235375183
Autor:
Satoko Koga, Hideya Onishi, Shogo Masuda, Akiko Fujimura, Shu Ichimiya, Kazunori Nakayama, Akira Imaizumi, Kenichi Nishiyama, Masayuki Kojima, Kei Miyoshi, Katsuya Nakamura, Masayo Umebayashi, Takashi Morisaki, Masafumi Nakamura
Publikováno v:
Translational Oncology, Vol 14, Iss 9, Pp 101152- (2021)
In our previous study, we found that inhibition of protein tyrosine phosphatase non-receptor type 3 (PTPN3), which is expressed in lymphocytes, enhances lymphocyte activation, suggesting PTPN3 may act as an immune checkpoint molecule. However, PTPN3
Externí odkaz:
https://doaj.org/article/84661136be934983893ab0deca732d5f
Autor:
Makoto Kawamoto, Yoshiyuki Wada, Norihiro Koya, Yuko Takami, Hideki Saitsu, Naoki Ishizaki, Mineo Tabata, Hideya Onishi, Masafumi Nakamura, Takashi Morisaki
Publikováno v:
Surgical Case Reports, Vol 4, Iss 1, Pp 1-8 (2018)
Abstract Background Gallbladder cancer (GBC) is one of the refractory diseases. Multidisciplinary approach including immunotherapy for such cancers has received much attention in recent years. Case presentation A 59-year-old man underwent an extended
Externí odkaz:
https://doaj.org/article/6c3cfe2bf2d34b2b928925aa338ec8d8
Autor:
Makoto Kawamoto, Hideya Onishi, Norihiro Koya, Hiroyuki Konomi, Kenji Mitsugi, Risa Tanaka, Junichi Motoshita, Takashi Morisaki, Masafumi Nakamura
Publikováno v:
Surgical Case Reports, Vol 3, Iss 1, Pp 1-6 (2017)
Abstract Background The prognosis of stage IV gastric cancer (GC) still remains unfavorable. Multidisciplinary approaches should therefore be considered to improve the survival of patients with stage IV GC. We report here a case of primary GC with po
Externí odkaz:
https://doaj.org/article/e4299ec51a2646a38da24723af85b7ae
Autor:
Shogo Masuda, Hideya Onishi, Naoya Iwamoto, Akira Imaizumi, Satoko Koga, Shinjiro Nagao, Keita Sakanashi, Shinsaku Itoyama, Akiko Fujimura, Noritaka Komune, Ryunosuke Kogo, Masayo Umebayashi, Takashi Morisaki, Takashi Nakagawa
Publikováno v:
Journal of Immunotherapy; Apr2024, Vol. 47 Issue 3, p89-97, 9p