Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Takashi Matozaki"'
Autor:
Mayuki Omatsu, Yuki Nakanishi, Kosuke Iwane, Naoki Aoyama, Angeles Duran, Yu Muta, Anxo Martinez-Ordoñez, Qixiu Han, Nobukazu Agatsuma, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mio Namikawa, Kensuke Hamada, Yuichi Fukunaga, Takahiro Utsumi, Makoto Sono, Tomonori Masuda, Akitaka Hata, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Satoshi Ogawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Toshiaki Kogame, Hiroaki Kasashima, Nobuyuki Kakiuchi, Masahiro M. Nakagawa, Kenji Kawada, Masakazu Yashiro, Kiyoshi Maeda, Yasuyuki Saito, Takashi Matozaki, Akihisa Fukuda, Kenji Kabashima, Kazutaka Obama, Seishi Ogawa, Nader Sheibani, Maria T. Diaz-Meco, Jorge Moscat, Hiroshi Seno
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving progression and metastasis. Targetable molecules in the tumor microenvironment
Externí odkaz:
https://doaj.org/article/faf191500a2f4f9e8f8e32b58ac4ba14
Autor:
Yasuyuki Saito, Rie Iida-Norita, Tania Afroj, Alaa Refaat, Daisuke Hazama, Satomi Komori, Shinya Ohata, Tomoko Takai, Okechi S. Oduori, Takenori Kotani, Yohei Funakoshi, Yu-Ichiro Koma, Yoji Murata, Kimikazu Yakushijin, Hiroshi Matsuoka, Hironobu Minami, Hiroshi Yokozaki, Markus G. Manz, Takashi Matozaki
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment and are considered potential targets for cancer immunotherapy. To examine the antitumor effects of agents targeting human TAMs in vivo, we here established preclinical tum
Externí odkaz:
https://doaj.org/article/784d3137dd2e455384e08104a9ce3615
Autor:
Takenori Kotani, Jajar Setiawan, Tasuku Konno, Noriko Ihara, Saki Okamoto, Yasuyuki Saito, Yoji Murata, Tetsuo Noda, Takashi Matozaki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Cell signaling important for homeostatic regulation of colonic epithelial cells (CECs) remains poorly understood. Mammalian target of rapamycin complex 1 (mTORC1), a protein complex that contains the serine-threonine kinase mTOR, mediates si
Externí odkaz:
https://doaj.org/article/e259b404b0d9467a82163ad3fbd8cc8b
Autor:
Gerard Elberg, Sigal Liraz-Zaltsman, Fanny Reichert, Takashi Matozaki, Michael Tal, Shlomo Rotshenker
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Recovery of function from traumatic nerve injury depends on the ability of severed axons to grow/regenerate back to their target tissues. This is achieved by successfully crossing the lesion site where physical impact severed axon
Externí odkaz:
https://doaj.org/article/69614fe77c6a4fc6a55d5baed287356e
Autor:
Takenori Kotani, Noriko Ihara, Saki Okamoto, Jajar Setiawan, Tasuku Konno, Yasuyuki Saito, Yoji Murata, Takashi Matozaki
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256774 (2021)
Cross talk between different signaling pathways is thought to be important for regulation of homeostasis of, as well as oncogenesis of, the intestinal epithelium. Expression of an active form of K-Ras specifically in intestinal epithelial cells (IECs
Externí odkaz:
https://doaj.org/article/3dc6677168d443738bc23e40aae51d3f
Autor:
Katka Franke, Saravanan Y. Pillai, Mark Hoogenboezem, Marion J. J. Gijbels, Hanke L. Matlung, Judy Geissler, Hugo Olsman, Chantal Pottgens, Patrick J. van Gorp, Maria Ozsvar-Kozma, Yasuyuki Saito, Takashi Matozaki, Taco W. Kuijpers, Rudi W. Hendriks, Georg Kraal, Christoph J. Binder, Menno P. J. de Winther, Timo K. van den Berg
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The inhibitory immunoreceptor SIRPα is expressed on myeloid and neuronal cells and interacts with the broadly expressed CD47. CD47-SIRPα interactions form an innate immune checkpoint and its targeting has shown promising results in cancer patients.
Externí odkaz:
https://doaj.org/article/ee6a819bfd8145e18c05d69a81a9717a
Autor:
Bochao Wang, Kouichi Hara, Akiko Kawabata, Mitsuhiro Nishimura, Aika Wakata, Lidya Handayani Tjan, Anna Lystia Poetranto, Chisato Yamamoto, Yasunari Haseda, Taiki Aoshi, Lisa Munakata, Ryo Suzuki, Masato Komatsu, Ryuko Tsukamoto, Tomoo Itoh, Chikako Nishigori, Yasuyuki Saito, Takashi Matozaki, Yasuko Mori
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008609 (2020)
Primary infection of human herpesvirus 6B (HHV-6B) occurs in infants after the decline of maternal immunity and causes exanthema subitum accompanied by a high fever, and it occasionally develops into encephalitis resulting in neurological sequelae. T
Externí odkaz:
https://doaj.org/article/1bc42e2b18414aa7aa4b1be7d0e62f42
Autor:
Mitsuharu Watanabe, Yoriaki Kaneko, Yuko Ohishi, Masato Kinoshita, Toru Sakairi, Hidekazu Ikeuchi, Akito Maeshima, Yasuyuki Saito, Hiroshi Ohnishi, Yoshihisa Nojima, Takashi Matozaki, Keiju Hiromura
Publikováno v:
Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)
Tissue resident mononuclear phagocytes (Mophs), comprising monocytes, macrophages, and dendritic cells (DCs), play important roles under physiological and pathological conditions. The presence of these cells in the kidney has been known for decades,
Externí odkaz:
https://doaj.org/article/6eb6f882e76249a9b68652a890f92ac8
Autor:
Sanne M. Meinderts, Per-Arne Oldenborg, Boukje M. Beuger, Thomas R.L. Klei, Johanna Johansson, Taco W. Kuijpers, Takashi Matozaki, Elise J. Huisman, Masja de Haas, Timo K. van den Berg, Robin van Bruggen
Publikováno v:
Blood Advances, Vol 1, Iss 14, Pp 875-886 (2017)
Abstract: Red blood cell (RBC) clearance is known to occur primarily in the spleen, and is presumed to be executed by red pulp macrophages. Erythrophagocytosis in the spleen takes place as part of the homeostatic turnover of RBCs to remove old RBCs.
Externí odkaz:
https://doaj.org/article/35136858b7b643d18bc4326c31e3fc80
Autor:
Miho Sato-Hashimoto, Tomomi Nozu, Riho Toriba, Ayano Horikoshi, Miho Akaike, Kyoko Kawamoto, Ayaka Hirose, Yuriko Hayashi, Hiromi Nagai, Wakana Shimizu, Ayaka Saiki, Tatsuya Ishikawa, Ruwaida Elhanbly, Takenori Kotani, Yoji Murata, Yasuyuki Saito, Masae Naruse, Koji Shibasaki, Per-Arne Oldenborg, Steffen Jung, Takashi Matozaki, Yugo Fukazawa, Hiroshi Ohnishi
Publikováno v:
eLife, Vol 8 (2019)
A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c+ microglia, as well as the mechanism of its induction, are poorly understood. Here we report that the genetic ablation of
Externí odkaz:
https://doaj.org/article/8bca47c9b3664098b6aa35fd634ec088