Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Takashi Kyoi"'
Autor:
Naoki Inoue, Asami Hashino, Kiyoto Kageyama, Xin Zhang, Takahiro Sasagawa, Naoko Kawakita, Yosuke Takahashi, Katsumi Yoshida, Mikiko Hashimoto, Kazuya Mori, Takashi Kyoi
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 1, Pp 73-82 (2010)
NS-126 (9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-cyclohexanecarboxylate 17-cyclopropanecarboxylate) is a novel, highly lipophilic anti-inflammatory corticosteroid. We compared NS-126 and the widely used intranasal cort
Externí odkaz:
https://doaj.org/article/89d2f6f40d0d417a935f6e1aca25d706
Autor:
Naoki Inoue, Sunao Ito, Koyuki Tajima, Masaki Nogawa, Yosuke Takahashi, Takahiro Sasagawa, Akio Nakamura, Takashi Kyoi
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 4, Pp 600-605 (2009)
Cyclooxygenase (COX) contributes to neuropathic pain after peripheral nerve injury, yet COX inhibitors are generally ineffective against mechanical allodynia and hyperalgesia in neuropathic pain patients and animal models. In the present study, we in
Externí odkaz:
https://doaj.org/article/e18eed70af664bb0a0017c859ca9b867
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 3, Pp 321-328 (2004)
The effects of selective inhibitors of phosphodiesterase type IV (PDE4) on ischemia-reperfusion-induced gastric injuries were investigated in rats. Gastric ischemia was induced by applying a small clamp to the celiac artery, and reoxygenation was per
Externí odkaz:
https://doaj.org/article/4a98e4ad4b86456d89c9fd8b324352e0
Publikováno v:
Journal of Pharmacological Sciences, Vol 93, Iss 3, Pp 314-320 (2003)
ABSTRACT: The inhibitory effect of an anti-ulcer drug irsogladine [2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate] on monochloramine (NH2Cl)-induced gastric mucosal lesions and its mechanisms of action were clarified in rats. Irsogladine dose-
Externí odkaz:
https://doaj.org/article/dc43b916276c4ac1bca9f932efeb2d96
Autor:
Kenjiro Hayashi, Koichi Sato, Seishi Ochi, Shuhei Kawano, Seiichi Munesue, Ai Harashima, Yu Oshima, Kumi Kimura, Takashi Kyoi, Yasuhiko Yamamoto
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5757
Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activation. In this study, we examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21051e1f5db9811a6fc2cc6ab7e561a3
Autor:
Kenjiro, Hayashi, Koichi, Sato, Seishi, Ochi, Shuhei, Kawano, Seiichi, Munesue, Ai, Harashima, Yu, Oshima, Kumi, Kimura, Takashi, Kyoi, Yasuhiko, Yamamoto
Publikováno v:
International journal of molecular sciences. 23(10)
Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activation. In this study, we examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4af394703e57309133d8dcec2bab6c6b
https://pubmed.ncbi.nlm.nih.gov/35628567
https://pubmed.ncbi.nlm.nih.gov/35628567
Autor:
Akio Nakamura, Masaki Nogawa, Takahiro Sasagawa, Sunao Ito, Yasuhiro Yamashita, Takashi Kyoi, Naoki Inoue, Kouji Banno, Takashi Kotera, Makoto Ueda, Yosuke Takahashi, Koyuki Tajima
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:53-60
The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2835c8bfb9ad6a313f314deb2d8eae
https://doi.org/10.1124/jpet.111.187401
https://doi.org/10.1124/jpet.111.187401
Publikováno v:
Pharmacology. 90:47-54
Background and Purpose: The excitability of nociceptors is modulated by the transient receptor potential cation channel, ankyrin subfamily, member 1 (TRPA1). We have previously reported that etodolac, a nonsteroidal anti-inflammatory drug, attenuates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a626b1acc59f595c55e678e0d41dec
https://doi.org/10.1159/000338756
https://doi.org/10.1159/000338756
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:655-659
The anti-inflammatory agent etodolac is used worldwide and it has a good gastrointestinal safety profile. Etodolac consists of two enantiomers, S- and R-etodolac. Here, we investigated the beneficial activities of racemic etodolac and its enantiomers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3faadd6018d5a3efffebdb06c444ea4
https://doi.org/10.1248/bpb.34.655
https://doi.org/10.1248/bpb.34.655
Autor:
Yosuke Takahashi, Takashi Kyoi, Koyuki Tajima, Sunao Ito, Akio Nakamura, Naoki Inoue, Takahiro Sasagawa, Masaki Nogawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 4, Pp 600-605 (2009)
Cyclooxygenase (COX) contributes to neuropathic pain after peripheral nerve injury, yet COX inhibitors are generally ineffective against mechanical allodynia and hyperalgesia in neuropathic pain patients and animal models. In the present study, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21f7ec966174fbc61db5804bdaad45e
http://www.sciencedirect.com/science/article/pii/S1347861319312435
http://www.sciencedirect.com/science/article/pii/S1347861319312435