Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Takashi Kusama"'
Autor:
Makiko Shimizu, Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Norie Murayama, Erika Sasaki, Kanami Shimura, Kazuyuki Nakanishi, Takashi Kusama, Yusuke Kamiya, Hiroshi Yamazaki
Publikováno v:
Biochemical Pharmacology. 152:272-278
Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical studies. An anti-inflammatory drug, diclofenac is reportedly metabolized mainly by human cytochrome P450 (P450) 2C9 to 4′-hydroxydiclofenac and min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44db96d686cc995c3b53168b510d9ea5
https://doi.org/10.1016/j.bcp.2018.04.002
https://doi.org/10.1016/j.bcp.2018.04.002
Autor:
Hiroshi Yamazaki, Shotaro Uehara, Yasuhiro Uno, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Takashi Inoue, Erika Sasaki, Takashi Kusama
Publikováno v:
Xenobiotica. 48:1072-1077
1. Simulated clearances of R-warfarin and efavirenz were recently reported for individual cynomolgus monkeys genotyped for cytochrome P450 2C19 and 2C9, respectively. To expand and verify this modeling procedure, simulations of R/S-omeprazole and R/S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a156c12c9fd4eff36d43e069ee6158
https://doi.org/10.1080/00498254.2017.1393121
https://doi.org/10.1080/00498254.2017.1393121
Autor:
Masahiro Utoh, Tomonori Miura, Yasuhiro Uno, Takahiro Hirano, Takashi Kusama, Marina Mitsui, Hiroshi Yamazaki, Makiko Shimizu, Mirai Kawano
Publikováno v:
Xenobiotica. 48:206-210
1. Cynomolgus monkey cytochrome P450 2C19 (formerly known as P450 2C75), homologous to human P450 2C19, has been identified as R-warfarin 7-hydroxylase. In this study, simulations of R-warfarin clearance in individual cynomolgus monkeys genotyped for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31d9c7f83c53ca01623b5fa4d63b828
https://doi.org/10.1080/00498254.2017.1288945
https://doi.org/10.1080/00498254.2017.1288945
Autor:
Hiroshi Yamazaki, Akiko Toda, Shotaro Uehara, Norie Murayama, Yusuke Kamiya, Hiroshi Suemizu, Takashi Kusama, Tomonori Miura, Mayuko Nakazato, Makiko Shimizu
Publikováno v:
The Journal of toxicological sciences. 44(8)
Long-term exposure to certain volatile organic compounds is a significant public health concern. A variety of food containers and drinking cups prepared from polystyrene or polystyrene-related plastics could contain styrene monomer. In the current st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452c8670f1ce2c2e939c868d7731b693
https://pubmed.ncbi.nlm.nih.gov/31378765
https://pubmed.ncbi.nlm.nih.gov/31378765
Autor:
Makiko Shimizu, Sawa Mizuno, Hiroshi Suemizu, Hiroshi Yamazaki, Takashi Kusama, Shotaro Uehara, Tomonori Miura
Publikováno v:
The Journal of toxicological sciences. 43(6)
Medicinal carnitine-derived and dietary-derived malodorous trimethylamine and its non-malodorous metabolite trimethylamine N-oxide were historically regarded as nontoxic. Clinical and toxicological interest has recently arisen because of their potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfccd5f40222e950b77c5c5ecda04f6c
https://pubmed.ncbi.nlm.nih.gov/29877215
https://pubmed.ncbi.nlm.nih.gov/29877215
Autor:
Masayuki Mogi, Shotaro Uehara, Takashi Kusama, Yasuhiro Uno, Makiko Shimizu, Akiko Toda, Erika Sasaki, Hiroshi Yamazaki, Takashi Inoue, Masahiro Utoh
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(7)
1. The pharmacokinetics were investigated for human cytochrome P450 probes after single intravenous and oral administrations of 0.20 and 1.0 mg/kg, respectively, of caffeine, warfarin, omeprazole, metoprolol and midazolam to aged (10-14 years old, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c8ee544468450d9e9f45325787796c
https://pubmed.ncbi.nlm.nih.gov/28686070
https://pubmed.ncbi.nlm.nih.gov/28686070
Autor:
Shotaro Uehara, Tomonori Miura, Yasuhiro Uno, Makiko Shimizu, Masahiro Utoh, Hiroshi Yamazaki, Takashi Kusama
Publikováno v:
Biopharmaceuticsdrug disposition. 38(7)
Cynomolgus monkey cytochrome P450 2C9 (formerly known as P450 2C43) variation was reportedly associated with metabolic clearance of the antiretroviral drug efavirenz in vivo (in three wild-type, one heterozygote and two homozygote animals), being unl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2404842af37d82cc3be087a3103078d
https://pubmed.ncbi.nlm.nih.gov/28608515
https://pubmed.ncbi.nlm.nih.gov/28608515
The aim of this work is to improve the recognition performance of spontaneous speech. In order to achieve the purpose, the authors of this chapter propose new approaches of unsupervised adaptation for spontaneous speech and evaluate the methods by us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78db5378cee26ad85e3b7f0c364c46d1
https://doi.org/10.4018/978-1-61520-871-5.ch016
https://doi.org/10.4018/978-1-61520-871-5.ch016
Autor:
Takashi Kusama, Toshiyuki Ohkami
Publikováno v:
Doboku Gakkai Ronbunshu. 1992:167-175
Lagrange 多項式は内挿関数として広く用いられている. しかしながら, 高次多項式は, Runge の問題, Bernstein の問題などのように曲線に対する適合性がよくない場合がある. 本文は線形関係を
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5b2a032f4538a9009629f080f782f78
https://doi.org/10.2208/jscej.1992.446_167
https://doi.org/10.2208/jscej.1992.446_167
Publikováno v:
Doboku Gakkai Ronbunshu. 1990:205-213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9018e771f4e63fa61719a9de50a7c6e9
https://doi.org/10.2208/jscej.1990.416_205
https://doi.org/10.2208/jscej.1990.416_205