Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Takashi Kurohara"'
Autor:
Hidetomo Yokoo, Nobumichi Ohoka, Mami Takyo, Takahito Ito, Keisuke Tsuchiya, Takashi Kurohara, Kiyoshi Fukuhara, Takao Inoue, Mikihiko Naito, Yosuke Demizu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8772 (2021)
Peptide-based target protein degradation inducers called PROTACs/SNIPERs have low cell penetrability and poor intracellular stability as drawbacks. These shortcomings can be overcome by easily modifying these peptides by conjugation with cell penetra
Externí odkaz:
https://doaj.org/article/bacf65a5757446ff8279bef36cf1143a
Autor:
Hirokazu Mishima, Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki, Naoya Asada, Ken‐ichi Kusakabe, Yuko Okamoto
Publikováno v:
Journal of Computational Chemistry. 44:1604-1609
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32bb8a93832574088f3e90ab7a2aaec7
https://doi.org/10.1002/jcc.27111
https://doi.org/10.1002/jcc.27111
Autor:
Mami Takyo, Yumi Sato, Naoya Hirata, Keisuke Tsuchiya, Hiroaki Ishida, Takashi Kurohara, Yuta Yanase, Takahito Ito, Yasunari Kanda, Keiko Yamamoto, Takashi Misawa, Yosuke Demizu
Publikováno v:
ACS Omega. 7(50):46573-46582
The vitamin D receptor (VDR) is a nuclear receptor, which is involved in several physiological processes, including differentiation and bone homeostasis. The VDR is a promising target for the development of drugs against cancer and bone-related disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cae905381b7eb59715143fed360a172
https://ousar.lib.okayama-u.ac.jp/64268
https://ousar.lib.okayama-u.ac.jp/64268
Autor:
Yuki Murakami, Hinata Osawa, Takashi Kurohara, Yuta Yanase, Takahito Ito, Hidetomo Yokoo, Norihito Shibata, Mikihiko Naito, Kosuke Aritake, Yosuke Demizu
Publikováno v:
RSC Medicinal Chemistry. 13:1495-1503
SAR studies of PROTACs that target H-PGDS, focusing on the E3 ligase ligand and the H-PGDS ligand, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e077833a5ea1afdf4b6a4883f35896f
https://doi.org/10.1039/d2md00284a
https://doi.org/10.1039/d2md00284a
Autor:
Hirokazu Mishima, Takayoshi Suzuki, Yukihiro Itoh, Naoya Asada, Takashi Kurohara, Ken-ichi Kusakabe, Yuko Okamoto
Publikováno v:
Journal of Computational Chemistry; 7/5/2023, Vol. 44 Issue 18, p1604-1609, 6p
Autor:
Hanqiao Xu, Takashi Kurohara, Reina Takano, Hidetomo Yokoo, Norihito Shibata, Nobumichi Ohoka, Takao Inoue, Mikihiko Naito, Yosuke Demizu
Publikováno v:
ChemistryOpen. 11
Optimizing linker design is important for ensuring efficient degradation activity of proteolysis-targeting chimeras (PROTACs). Therefore, developing a straightforward synthetic approach that combines the protein-of-interest ligand (POI ligand) and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd63949de0bbb213c6d3b59ed54c63ae
https://doi.org/10.1002/open.202200131
https://doi.org/10.1002/open.202200131
Autor:
Minami Fujita, Keisuke Tsuchiya, Takashi Kurohara, Kiyoshi Fukuhara, Takashi Misawa, Yosuke Demizu
Publikováno v:
Bioorganic & Medicinal Chemistry. 84:117264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88268f8fe8c9ba544b647e65f967923b
https://doi.org/10.1016/j.bmc.2023.117264
https://doi.org/10.1016/j.bmc.2023.117264
Publikováno v:
Bioorganic & Medicinal Chemistry. 84:117259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d04f0c02e9ec3587bb13baa2b97cf564
https://doi.org/10.1016/j.bmc.2023.117259
https://doi.org/10.1016/j.bmc.2023.117259
Autor:
Yosuke Ota, Yukihiro Itoh, Takashi Kurohara, Ritesh Singh, Elghareeb E. Elboray, Chenliang Hu, Farzad Zamani, Anirban Mukherjee, Yuri Takada, Yasunobu Yamashita, Mie Morita, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki
Publikováno v:
ACS medicinal chemistry letters. 13(10)
Anticancer drug delivery by small molecules offers a number of advantages over conventional macromolecular drug delivery systems. We previously developed phenylcyclopropylamine (PCPA)-drug conjugates (PDCs) as small-molecule-based drug delivery vehic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532973eca856d52a01da6f15b203605f
https://pubmed.ncbi.nlm.nih.gov/36262394
https://pubmed.ncbi.nlm.nih.gov/36262394