Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Takashi Kawashiro"'
Autor:
Makoto Niwa, Takashi Kawashiro
Publikováno v:
Biomedical Chromatography. 25:517-523
A sensitive high-performance liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for measuring vinorelbine was developed. A 100 µL aliquot of plasma was spiked with deuterium-labeled internal standard and subjected to solid-phase extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828d220b55c1c29b3a2d48296ff5c3d9
https://doi.org/10.1002/bmc.1477
https://doi.org/10.1002/bmc.1477
Autor:
Makoto Niwa, Takashi Kawashiro
Publikováno v:
YAKUGAKU ZASSHI. 129:993-999
Applicability of atmospheric pressure photoionization mass spectrometry (APPI-MS) to the analysis of hydrophilic drugs was investigated. Model compounds with moderate to high hydrophilicity was tested, and most compounds showed good signal response w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7842ea991bb279d9c086f425b468101f
https://doi.org/10.1248/yakushi.129.993
https://doi.org/10.1248/yakushi.129.993
Autor:
Kaoru Takanaka, Yukiharu Nakayama, Keiichi Ida, Shunichi Kametani, Toshio Inoda, Takashi Izumi, Masato Tani, Kouichi Nakamura, Eiji Kashiyama, Shigemichi Morita, Fukuichi Ohsawa, Shuichi Sakai, Meguru Achira, Akira Kagayama, Satoru Asahi, Nobuo Osawa, Jun Morita, Yoshinobu Yoshimura, Kimitoshi Saito, Yoshiaki Terauchi, Takuro Niwa, Osamu Takenaka, Takanori Hashizume, Kiyoshi Noguchi, Toshifumi Shiraga, Yasuhiro Nakai, Satoshi Omori, Akinori Aoyama, Takashi Kuwabara, Hiroyuki Kawai, Akio Nakamura, Toshiyuki Kume, Sekio Nagayama, Masahiko Iwasaki, Takuya Yoshimura, Mitsuaki Takeuchi, Hideki Nakamura, Takashi Kawashiro, Takeshi Nakabayashi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 19:444-452
As a part of the studies conducted by the Pharma SNPs Consortium (PSC), the enzyme activities of CYP1A2, CYP2A6 and CYP2B6 variants with altered amino acids as a result of single nucleotide polymorphisms (SNPs) found among the Japanese population wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8022493d1f872622e180d5d0b15d9e
https://doi.org/10.2133/dmpk.19.444
https://doi.org/10.2133/dmpk.19.444
Publikováno v:
Drug metabolism and pharmacokinetics. 30(5)
Toremifene (TOR) and Tamoxifen (TAM) are widely used as endocrine therapy for estrogen receptor positive breast cancer. Poor metabolizers of TAM are likely to have worse clinical outcomes than patients who exhibit normal TAM metabolism due to lower p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1705966cadbfdf63214747896cc0d82f
https://pubmed.ncbi.nlm.nih.gov/26423799
https://pubmed.ncbi.nlm.nih.gov/26423799
Autor:
Kazue Nemoto, Shuichiro Tsutsumi, Takashi Kawashiro, Hiroki Ebine, Kouwa Yamashita, Takuo Washio, Kazuhiro Kohsaka, Atsushi Takao, Yayoi Shimizu, Takashi Nogami
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:553-557
The absorption, excretion and metabolism of SNI-2011, a novel muscarinic acetylcholine receptor agonist developed as an agent improving the symptoms of dry mouth or dry eye caused by Sjogren's syndrome, were studied in dogs. 1. After a single oral ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbab5f3b7e438fe959529e48cc5ba736
https://doi.org/10.2133/dmpk.16.553
https://doi.org/10.2133/dmpk.16.553
Autor:
Shin-ichi Shimada, Makoto Niwa, Yayoi Yoshioka, Kazuhiro Kohsaka, Takashi Nogami, Kazue Nemoto, Shuichiro Tsutsumi, Takuo Washio, Takashi Kawashiro, Toshie Tomizuka, Hiroki Ebine, Atsushi Takao, Akinori Wakaiki, Yayoi Shimizu, Kouwa Yamashita, Ken-ichi Nakano, Masato Suwa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:537-552
The absorption, distribution, metabolism, excretion and plasma protein binding of SNI-2011, a novel muscarinic acetylcholine receptor agonist developed as an agent improving the symptoms of dry mouth or dry eye caused by Sjogren's syndrome, were stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8c2139933a71137f59e819de33724d1
https://doi.org/10.2133/dmpk.16.537
https://doi.org/10.2133/dmpk.16.537
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 32:313-317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7d34d958297c2d24d00ec9b79ba3916
https://doi.org/10.3999/jscpt.32.6_313
https://doi.org/10.3999/jscpt.32.6_313
Autor:
Toshiya Yamaguchi, Iwao Nakamura, Keiko Ebara, Takafumi Ichida, Eiji Ichimura, Chihiro Nishimura, Hiroko Mashiba, Kazuya Okamoto, Naoko Nakajima, Takashi Kawashiro, Yuh-ichiro Ichikawa
Publikováno v:
Drug Discoveries & Therapeutics.
We conducted an in vivo study to evaluate the anticancer effect and toxicity of fine- powder cisplatin suspended in lipiodol (fCDDP/LPD suspension) after a single administration of three different doses to rats via the intrahepatic artery after trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a27c8e26b589b5964c01086a70e6b7
https://doi.org/10.5582/ddt.2013.v7.5.201
https://doi.org/10.5582/ddt.2013.v7.5.201
Autor:
Takashi Kawashiro, Eiji Ichimura, Takeshi Onda, Shin-ichi Matsumoto, Chihiro Nishimura, Kazuya Okamoto, Hitomi Hayashi, Noriko Watanabe, Masuda Kuniko
Publikováno v:
Cancer Research. 70:5522-5522
Introduction: NK012 is a novel micelle-forming macromolecular prodrug of SN-38, an active metabolite of irinotecan (CPT-11), which is gradually released from the molecule in an enzyme-independent manner at physiological pH. We have demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c99747e9c9f1a55b2660552139e4461
https://doi.org/10.1158/1538-7445.am10-5522
https://doi.org/10.1158/1538-7445.am10-5522
Autor:
TAKASHI KAWASHIRO
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:266-266
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ef88c0ff9d3fbcaf9cbd82918370b49
https://doi.org/10.2133/dmpk.12.266
https://doi.org/10.2133/dmpk.12.266