Zobrazeno 1 - 10
of 3 404
pro vyhledávání: '"Takashi K"'
Autor:
Alan Kivitz, Wesley DeHaan, Rehan Azeem, Justin Park, Sheri Rhodes, Jamie Inshaw, Sheldon S. Leung, Savvas Nicolaou, Lloyd Johnston, Takashi K. Kishimoto, Peter G. Traber, Earl Sands, Hyon Choi
Publikováno v:
Rheumatology and Therapy, Vol 10, Iss 4, Pp 825-847 (2023)
Abstract Introduction SEL-212 is a developmental treatment for uncontrolled gout characterized by serum uric acid (sUA) levels ≥ 6 mg/dl despite treatment. It comprises a novel PEGylated uricase (SEL-037; also called pegadricase) co-administered wi
Externí odkaz:
https://doaj.org/article/cf6f1cb3ba274f37b044035ffe0ee7d4
Autor:
Sousuke Okukawa, Kazuyuki Hara, Kinya Hibino, Yusaku Katayose, Kazumasa Kawata, Munehiro Ohnishi, Takashi Sako, Takashi K Sako, Makio Shibata, Atsushi Shiomi, Masato Takita
Publikováno v:
Machine Learning: Science and Technology, Vol 5, Iss 2, p 025016 (2024)
The Tibet AS γ experiment has been observing cosmic gamma rays and cosmic rays in the energy range from teraelectron volts to several tens of petaelectron volts with a surface detector array since 1990. The derivation of cosmic gamma-ray flux is mad
Externí odkaz:
https://doaj.org/article/7868266bff474167b95f3687e5b84a78
Autor:
Nicholas D. Weber, Leticia Odriozola, Irene Ros-Gañán, Guillermo García-Porrero, David Salas, Josepmaria Argemi, Jean-Philippe Combal, Takashi K. Kishimoto, Gloria González-Aseguinolaza
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100713- (2023)
Background & Aims: Gene therapy using recombinant adeno-associated virus (rAAV) vector carrying multidrug resistance protein 3 (MDR3) coding sequence (AAV8-MDR3) represents a potential curative treatment for progressive familial intrahepatic cholesta
Externí odkaz:
https://doaj.org/article/87de6a3ad3184e34980b1de9f40a5bae
Autor:
Takashi K. Ito, Tomohito Sato, Yusuke Takanashi, Zinat Tamannaa, Takuya Kitamoto, Keiichi Odagiri, Mitsutoshi Setou
Publikováno v:
Translational Medicine of Aging, Vol 5, Iss , Pp 43-51 (2021)
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple species, including humans. Our previous clinical trial showed that supplementation of 200 mg nicotinamide, a form of vitamin B3, increased blood NAD+ lev
Externí odkaz:
https://doaj.org/article/2049627f6360406f8f653386934dc2ab
Autor:
Takashi K. Ito, Tomohito Sato, Akio Hakamata, Yuki Onoda, Shumpei Sato, Fumiyoshi Yamazaki, Makoto Horikawa, Yutaka Takahashi, Takuya Kitamoto, Masako Suzuki, Shinya Uchida, Keiichi Odagiri, Mitsutoshi Setou
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 45-54 (2020)
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of v
Externí odkaz:
https://doaj.org/article/f4fdfd2190064feea97ad4bed3f1f17e
Autor:
Hirokazu Madokoro, Kota Takahashi, Satoshi Yamamoto, Stephanie Nix, Shun Chiyonobu, Kazuki Saruta, Takashi K. Saito, Yo Nishimura, Kazuhito Sato
Publikováno v:
Applied Sciences, Vol 12, Iss 15, p 7785 (2022)
Classification, segmentation, and recognition techniques based on deep-learning algorithms are used for smart farming. It is an important and challenging task to reduce the time, burden, and cost of annotation procedures for collected datasets from f
Externí odkaz:
https://doaj.org/article/c30f0be50688405a8adcf86408899ca6
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 13, Iss C, Pp 18-22 (2017)
A major obstacle to enzyme replacement therapy (ERT) with recombinant human acid-α-glucosidase (rhGAA) for Pompe disease is the development of high titers of anti-rhGAA antibodies in a subset of patients, which often leads to a loss of treatment eff
Externí odkaz:
https://doaj.org/article/6982ba32545843df92fdc44f63a5bdd2
Autor:
Robert A. LaMothe, Pallavi N. Kolte, Trinh Vo, Joseph D. Ferrari, Tracy C. Gelsinger, Jodie Wong, Victor T. Chan, Sinthia Ahmed, Aditi Srinivasan, Patrick Deitemeyer, Roberto A. Maldonado, Takashi K. Kishimoto
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
T cells reacting to self-components can promote tissue damage when escaping tolerogenic control mechanisms which may result in autoimmune disease. The current treatments for these disorders are not antigen (Ag) specific and can compromise host immuni
Externí odkaz:
https://doaj.org/article/41c70cd556174c1e9d6f0707d851f21d
Autor:
Takashi K. Ito, Chenhao Lu, Jacob Khan, Quy Nguyen, Heather Z. Huang, Dayae Kim, James J. Phillips, Jo Tan, Yenna Lee, Tuyet Nguyen, Samy Khessib, Natalie Lim, Surapat Mekvanich, Joshua Oh, Victor V. Pineda, Weirong Wang, Alessandro Bitto, Jonathan Y. An, John F. Morton, Mitsutoshi Setou, Warren C. Ladiges, Matt Kaeberlein
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/c99404f4c52046d6b736e90ad388d71e
Autor:
Takashi K. Ito, Chenhao Lu, Jacob Khan, Quy Nguyen, Heather Z. Huang, Dayae Kim, James Phillips, Jo Tan, Yenna Lee, Tuyet Nguyen, Samy Khessib, Natalie Lim, Surapat Mekvanich, Joshua Oh, Victor V. Pineda, Weirong Wang, Alessandro Bitto, Jonathan Y. An, John F. Morton, Mitsutoshi Setou, Warren C. Ladiges, Matt Kaeberlein
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
The inactivation of ribosomal protein S6 kinase 1 (S6K1) recapitulates aspects of caloric restriction and mTORC1 inhibition to achieve prolonged longevity in invertebrate and mouse models. In addition to delaying normative aging, inhibition of mTORC1
Externí odkaz:
https://doaj.org/article/b9e4abcd91a34deea0dfa54c43c48b29