Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Takashi Izuhara"'
Autor:
Kazuhiro Watanabe, Wakako Yokota, Munenori Inoue, Takeyuki Suzuki, Tadashi Katoh, Ayaka Nobeyama, Takashi Izuhara
Publikováno v:
Tetrahedron. 62:1590-1608
The epoxycyclohexenone moieties 2 and 3b of scyphostatin ( 1 ), a potent and specific inhibitor of neutral sphingomyelinase, were synthesized in enantiomerically pure forms starting from (−)-quinic acid ( 11 ). The synthetic method features (i) the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e4ebd183a4e120bcb6adb927b52acab
https://doi.org/10.1016/j.tet.2005.10.082
https://doi.org/10.1016/j.tet.2005.10.082
Autor:
Takashi Izuhara, Tadashi Katoh
Publikováno v:
Tetrahedron Letters. 41:7651-7655
An efficient synthesis of (4 S ,5 S ,6 S )-6-benzyl-4,5-epoxy-6-hydroxy-2-cyclohexen-1-one ( 2 ) representing a model compound for the cyclohexenone moiety of scyphostatin ( 1 ) was accomplished; the method features masking of the enone system in 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::386f2db59c07f2ba047750c189ba16f7
https://doi.org/10.1016/s0040-4039(00)01312-5
https://doi.org/10.1016/s0040-4039(00)01312-5
Autor:
Kazuhiko Otoguro, Haruki Yamada, Takashi Izuhara, Aki Ishiyama, Miyuki Kobayashi, Toshiaki Sunazuka, Hitomi Sekiguchi, Hiroshi Tomoda, Satoshi Omura
Publikováno v:
The Journal of Antibiotics. 57:400-402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb61807d31902086cf5da30cdd01cb6
https://doi.org/10.7164/antibiotics.57.400
https://doi.org/10.7164/antibiotics.57.400
Autor:
Takashi Izuhara, Tadashi Katoh
Publikováno v:
ChemInform. 32
The cyclohexenone segment 2 of scyphostatin (1), a potent inhibitor of neutral sphingomyelinase, was synthesized in an enantioselective manner starting from the bromo ether 5 and d-serinal derivative 3. The synthetic method features a coupling reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4cf726dd5551305be9c4fd05c678c00
https://doi.org/10.1002/chin.200137035
https://doi.org/10.1002/chin.200137035
Autor:
Kazuro Shiomi,†,‡,§ and, Toshiaki Sunazuka, Tomoyasu Hirose, Satoshi Ōmura, Takashi Izuhara, Hiroyuki Shimamura
Publikováno v:
Organic letters. 9(1)
[reaction: see text] Total synthesis of verticipyrone, a novel NADH-fumarate reductase inhibitor, has been accomplished by a convergent approach using novel "Reverse Julia olefination" method. During total synthetic studies, we also prepared and eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71c0363bebaf6b93b75358989945412
https://pubmed.ncbi.nlm.nih.gov/17192086
https://pubmed.ncbi.nlm.nih.gov/17192086
Publikováno v:
Angewandte Chemie (International ed. in English). 43(32)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fe59e3bbdcd5ff461063950902d6aa
https://pubmed.ncbi.nlm.nih.gov/15307088
https://pubmed.ncbi.nlm.nih.gov/15307088
Autor:
Tadashi Katoh, Takashi Izuhara
Publikováno v:
Organic letters. 3(11)
The cyclohexenone segment 2 of scyphostatin (1), a potent inhibitor of neutral sphingomyelinase, was synthesized in an enantioselective manner starting from the bromo ether 5 and d-serinal derivative 3. The synthetic method features a coupling reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd4b4fb9816265ee475cc9d022e3fa3
https://pubmed.ncbi.nlm.nih.gov/11405678
https://pubmed.ncbi.nlm.nih.gov/11405678
Publikováno v:
HETEROCYCLES. 56:553
(S)-4-Benzyl-3-(p-toluenesulfonyl)-2-oxazolidinone (6) was synthesized as a simplified model substrate for the cyclohexenone subunit (2) of scyphostatin (1) starting from L-phenylalanine (3). Transformation of 6 to (S)-N-(l-benzyl-2-hydroxyethyl)hexa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c1f70b37a6be4e9ae57328c15a5304b
https://doi.org/10.3987/com-01-s(k)55
https://doi.org/10.3987/com-01-s(k)55