Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Takashi Ishiuchi"'
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 5, Pp 320-326 (2024)
Regulation of gene expression through histone modifications underlies cell homeostasis and differentiation. Kdm4d and Kdm4dl exhibit a high degree of similarity and demethylate H3K9me3. However, the physiological functions of these proteins remain un
Externí odkaz:
https://doaj.org/article/06f7941772a94cc8b6f84b4c180e427e
Autor:
Mizuki Sakamoto, Aoi Ito, Sayaka Wakayama, Hiroyuki Sasaki, Teruhiko Wakayama, Takashi Ishiuchi
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114118- (2024)
Summary: Zygotic genome activation (ZGA) after fertilization enables the maternal-to-zygotic transition. However, the global view of ZGA, particularly at initiation, is incompletely understood. Here, we develop a method to capture and sequence newly
Externí odkaz:
https://doaj.org/article/9ed8ec9cff2f42ee8f95fda64a19b2b8
Autor:
Seiichi Yano, Takashi Ishiuchi, Shusaku Abe, Satoshi H. Namekawa, Gang Huang, Yoshihiro Ogawa, Hiroyuki Sasaki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
DNMT3A is known to methylate DNA at histone H3 lysine 36 (H3K36me3)-marked transcriptionally active regions in mouse oocytes. Here the authors show that DNMT3A is also guided by H3K36me2 to methylate broad domains in genic and intergenic loci, as wel
Externí odkaz:
https://doaj.org/article/d14052d145fd491295690d0b53f6bf95
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The development of safe preservation methods for genetic resources is important. Here, the authors successfully produce cloned mice from freeze-dried somatic cells, demonstrating the possibility of safe and low-cost preservation of genetic resources.
Externí odkaz:
https://doaj.org/article/a9fbc47c206440e687a4263bcb2a5024
Publikováno v:
Epigenetics, Vol 16, Iss 10, Pp 1123-1134 (2021)
Histone lysine-to-methionine (K-to-M) mutations have been identified as driver mutations in human cancers. Interestingly, these ‘oncohistone’ mutations inhibit the activity of histone methyltransferases. Therefore, they can potentially be used as
Externí odkaz:
https://doaj.org/article/5be4f6b5062b4fd0baaf5383c2f8e329
Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development
Autor:
Takashi Ishiuchi, Hiroaki Ohishi, Tetsuya Sato, Satoshi Kamimura, Masayoshi Yorino, Shusaku Abe, Atsushi Suzuki, Teruhiko Wakayama, Mikita Suyama, Hiroyuki Sasaki
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1742-1754.e6 (2019)
Summary: Placental development is a key event in mammalian reproduction and embryogenesis. However, the molecular basis underlying placental development is not fully understood. Here, we conduct a forward genetic screen to identify regulators for ext
Externí odkaz:
https://doaj.org/article/320ddf41f2394174a2c62fe0da0b290c
Autor:
Takashi Ishiuchi, Mizuki Sakamoto
Publikováno v:
Life Science Alliance; Nov2023, Vol. 6 Issue 11, p1-8, 8p
Publikováno v:
Epigenetics
Histone lysine-to-methionine (K-to-M) mutations have been identified as driver mutations in human cancers. Interestingly, these ‘oncohistone’ mutations inhibit the activity of histone methyltransferases. Therefore, they can potentially be used as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01e0fa7d38734afeb877c768cdae538
https://doi.org/10.1080/15592294.2020.1841873
https://doi.org/10.1080/15592294.2020.1841873
Autor:
Yuka Miki, Shusaku Abe, Wan Kin Au Yeung, Takashi Ishiuchi, Atsuo Ogura, Kimiko Inoue, Hiroyuki Sasaki
Publikováno v:
Nature Structural & Molecular Biology. 28:38-49
Epigenetic reprogramming of the zygote involves dynamic incorporation of histone variant H3.3. However, the genome-wide distribution and dynamics of H3.3 during early development remain unknown. Here, we delineate the H3.3 landscapes in mouse oocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5589f5ea5e491ef4c95eaa2e1aa755a
https://doi.org/10.1038/s41594-020-00521-1
https://doi.org/10.1038/s41594-020-00521-1
Autor:
Mizuki Sakamoto, Daiyu Ito, Rei Inoue, Sayaka Wakayama, Yasuyuki Kikuchi, Li Yang, Erika Hayashi, Rina Emura, Hirosuke Shiura, Takashi Kohda, Satoshi H. Namekawa, Takashi Ishiuchi, Teruhiko Wakayama, Masatoshi Ooga
Publikováno v:
Development (Cambridge, England). 149(18)
Round spermatid injection (ROSI) results in a lower birth rate than intracytoplasmic sperm injection, which has hampered its clinical application. Inefficient development of ROSI embryos has been attributed to epigenetic abnormalities. However, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af43c9a789f0f230f3c4fc1bf5c50fcd
https://pubmed.ncbi.nlm.nih.gov/35993297
https://pubmed.ncbi.nlm.nih.gov/35993297