Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Takashi FURUSAWA"'
Autor:
Ravikanth Nanduri, Takashi Furusawa, Alexei Lobanov, Bing He, Carol Xie, Kimia Dadkhah, Michael C. Kelly, Oksana Gavrilova, Frank J. Gonzalez, Michael Bustin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
White adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the
Externí odkaz:
https://doaj.org/article/73d8ac3438a74fbb8ecb66a525062117
Autor:
Bing He, Iris Zhu, Yuri Postnikov, Takashi Furusawa, Lisa Jenkins, Ravikanth Nanduri, Michael Bustin, David Landsman
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract Background Nucleosomal binding proteins, HMGN, is a family of chromatin architectural proteins that are expressed in all vertebrate nuclei. Although previous studies have discovered that HMGN proteins have important roles in gene regulation
Externí odkaz:
https://doaj.org/article/b44bd378d4d748af8243cc81356595cf
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The nucleosome-binding proteins HMGN1 and HMGN2 prefer acetylated nucleosomes at H3K27ac and the loss of this interaction alters binding of transcription factors to chromatin.
Externí odkaz:
https://doaj.org/article/cc238a02973f426a873b928e07a51622
Autor:
Lucia Cabal-Hierro, Peter van Galen, Miguel A. Prado, Kelly J. Higby, Katsuhiro Togami, Cody T. Mowery, Joao A. Paulo, Yingtian Xie, Paloma Cejas, Takashi Furusawa, Michael Bustin, Henry W. Long, David B. Sykes, Steven P. Gygi, Daniel Finley, Bradley E. Bernstein, Andrew A. Lane
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification i
Externí odkaz:
https://doaj.org/article/f424d9b406fb49f7a429fe6474f60a2d
Autor:
Bing He, Tao Deng, Iris Zhu, Takashi Furusawa, Shaofei Zhang, Wei Tang, Yuri Postnikov, Stefan Ambs, Caiyi Cherry Li, Ferenc Livak, David Landsman, Michael Bustin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
HMGN1 and HMGN2 are ubiquitous nucleosome binding proteins. Here the authors provide evidence that HMGN proteins preferentially localize to chromatin regulatory sites to modulate the plasticity of the epigenetic landscape, proposing that HGMNs stabil
Externí odkaz:
https://doaj.org/article/acb87ff987c14ca2b815b9f6f7ffe5ff
Autor:
Akihiro UEMURA, Hironori MIYAZAWA, Takashi FURUSAWA, Satoru YAMAMOTO, Koichi YONEZAWA, Shuichi UMEZAWA, Shuichi OHMORI
Publikováno v:
Mechanical Engineering Journal, Vol 7, Iss 4, Pp 20-00068-20-00068 (2020)
The purpose of this study is to simulate unsteady steam flows through three-stage stator and rotor blade passages in a middle-pressure steam turbine operated in a power plant while considering manufactured and secular-changed blade shapes. The shapes
Externí odkaz:
https://doaj.org/article/770a9fdda7764a8da3834281e52f7dc8
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 449 (2020)
Chromatin plays a key role in regulating gene expression programs necessary for the orderly progress of development and for preventing changes in cell identity that can lead to disease. The high mobility group N (HMGN) is a family of nucleosome bindi
Externí odkaz:
https://doaj.org/article/b7f39a00780d4d7e8c36279e5f57793e
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression
Autor:
Cody T. Mowery, Jaime M. Reyes, Lucia Cabal-Hierro, Kelly J. Higby, Kristen L. Karlin, Jarey H. Wang, Robert J. Kimmerling, Paloma Cejas, Klothilda Lim, Hubo Li, Takashi Furusawa, Henry W. Long, David Pellman, Bjoern Chapuy, Michael Bustin, Scott R. Manalis, Thomas F. Westbrook, Charles Y. Lin, Andrew A. Lane
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1898-1911.e5 (2018)
Summary: Down syndrome (DS, trisomy 21) is associated with developmental abnormalities and increased leukemia risk. To reconcile chromatin alterations with transcriptome changes, we performed paired exogenous spike-in normalized RNA and chromatin imm
Externí odkaz:
https://doaj.org/article/70783644fe2f43be951838ad8302663a
Publikováno v:
Journal of Fluid Science and Technology, Vol 12, Iss 2, Pp JFST0018-JFST0018 (2017)
The causal relationship between unsteady forces of wet-steam flows on rotor-blade rows and the steam condensation in low pressure steam turbines is still one of unresolved issues. In this study, we investigate the effect of condensation on the time-d
Externí odkaz:
https://doaj.org/article/ed6c2b1398b340cdb8e27928e3a6276b
Autor:
Takashi FURUSAWA, Satoru YAMAMOTO
Publikováno v:
Journal of Fluid Science and Technology, Vol 12, Iss 1, Pp JFST0002-JFST0002 (2017)
Wet-steam flows under high-pressure conditions are numerically investigated using a newly derived condensation model that assumes a real gas and uses a real gas Equation of State (EOS). Under high-pressure conditions, the present condensation model c
Externí odkaz:
https://doaj.org/article/f2a8ecb53f8047cdab1971115c85d6c0