Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Takashi Ayaki"'
Autor:
Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract The aggregated alpha-synuclein (αsyn) in oligodendrocytes (OLGs) is one of the pathological hallmarks in multiple system atrophy (MSA). We have previously reported that αsyn accumulates not only in neurons but also in OLGs long after the a
Externí odkaz:
https://doaj.org/article/cd30b625e77b48f48134f51505938d29
Autor:
Sumio Minamiyama, Madoka Sakai, Yuko Yamaguchi, Makiko Kusui, Hideki Wada, Ryota Hikiami, Yoshitaka Tamaki, Megumi Asada-Utsugi, Akemi Shodai, Akiko Makino, Noriko Fujiwara, Takashi Ayaki, Takakuni Maki, Hitoshi Warita, Masashi Aoki, Keizo Tomonaga, Ryosuke Takahashi, Makoto Urushitani
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 312-329 (2023)
Superoxide dismutase1 (SOD 1) mutation is a leading cause of familial amyotrophic lateral sclerosis (ALS). Growing evidence suggests that antibody therapy against misfolded SOD1 protein can be therapeutic. However, the therapeutic effects are limited
Externí odkaz:
https://doaj.org/article/125f475f713e45e783a43ac5eb717f6d
Autor:
Mingyue Jin, Sakiko Matsumoto, Takashi Ayaki, Hodaka Yamakado, Tomoyuki Taguchi, Natsuko Togawa, Ayumu Konno, Hirokazu Hirai, Hiroshi Nakajima, Shoji Komai, Ryuichi Ishida, Syuhei Chiba, Ryosuke Takahashi, Toshifumi Takao, Shinji Hirotsune
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In this work, the authors show that α-synuclein is posttranslationally dopanized at Tyr136 by tyrosine hydroxylase, which facilitates the formation of oligomers. This modification likely impacts pathogenesis and the selective degeneration of dopamin
Externí odkaz:
https://doaj.org/article/ed3bba349ad1462fa25323761da6c9f0
Autor:
Ryota Hikiami, Toshifumi Morimura, Takashi Ayaki, Tomoyuki Tsukiyama, Naoko Morimura, Makiko Kusui, Hideki Wada, Sumio Minamiyama, Akemi Shodai, Megumi Asada-Utsugi, Shin-ichi Muramatsu, Takatoshi Ueki, Ryosuke Takahashi, Makoto Urushitani
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Genetic mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). Although mitochondrial dysfunction and stress granule have been crucially implicated in FUS proteinopathy, the molecular basis remains unclear. Here, we s
Externí odkaz:
https://doaj.org/article/466c0b9b2b744c3492877408d329cf97
Autor:
Megumi Asada-Utsugi, Kengo Uemura, Takashi Ayaki, Maiko T. Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryosuke Takahashi, Ayae Kinoshita, Makoto Urushitani
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Phosphorylated microtubule-associated protein tau (p-tau) accumulates at double-strand breaks (DSBs) in neurons. Loss of tau induces failure of DSB repair and excessive DSB accumulation, leading to aberrant p-tau aggregation and apoptotic neurons.
Externí odkaz:
https://doaj.org/article/de0adf46df324e2681f7db4538e8e628
Autor:
Erina Ono, Akira Ishii, Yoshiaki Higashi, Natsuko Koita, Takashi Ayaki, Katsuya Tanigaki, Shunsuke Takayanagi, Naoya Kondo, Kaoru Sakai, Shuichiro Endo, Hideki Yokoi, Takeshi Matsubara, Sachiko Minamiguchi, Ichizo Nishino, Ryosuke Takahashi, Motoko Yanagita
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background Lately, monoclonal gammopathy of renal significance (MGRS) has been defined as a group of renal disorders that are strongly associated with monoclonal protein, including amyloid immunoglobulin light chain (AL) amyloidosis. Amyloid
Externí odkaz:
https://doaj.org/article/3494f0f0d62b4d5bafcbe09b66373f12
Autor:
Seiji Kaji, Takakuni Maki, Jun Ueda, Tomoyuki Ishimoto, Yutaka Inoue, Ken Yasuda, Masanori Sawamura, Rie Hikawa, Takashi Ayaki, Hodaka Yamakado, Ryosuke Takahashi
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Multiple system atrophy (MSA) is pathologically characterized by the presence of fibrillar α-synuclein-immunoreactive inclusions in oligodendrocytes. Although the myelinating process of oligodendrocytes can be observed in adult human brains
Externí odkaz:
https://doaj.org/article/f29b433490d948c7880cd807b7c97654
Autor:
Takashi Kurashige, Masahito Kuramochi, Ryosuke Ohsawa, Yui Yamashita, Go Shioi, Hiroyuki Morino, Masaki Kamada, Takashi Ayaki, Hidefumi Ito, Yusuke Sotomaru, Hirofumi Maruyama, Hideshi Kawakami
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105215- (2021)
We previously showed that optineurin (OPTN) mutations lead to the development of amyotrophic lateral sclerosis. The association between OPTN mutations and the pathogenesis of amyotrophic lateral sclerosis remains unclear. To investigate the mechanism
Externí odkaz:
https://doaj.org/article/190dffdfc2224b6d86b31a6626a887da
Autor:
Seiji Kaji, Takakuni Maki, Hisanori Kinoshita, Norihito Uemura, Takashi Ayaki, Yasuhiro Kawamoto, Takahiro Furuta, Makoto Urushitani, Masato Hasegawa, Yusuke Kinoshita, Yuichi Ono, Xiaobo Mao, Tran H. Quach, Kazuhiro Iwai, Valina L. Dawson, Ted M. Dawson, Ryosuke Takahashi
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 356-365 (2018)
Summary: Glial cytoplasmic inclusions (GCIs), commonly observed as α-synuclein (α-syn)-positive aggregates within oligodendrocytes, are the pathological hallmark of multiple system atrophy. The origin of α-syn in GCIs is uncertain; there is little
Externí odkaz:
https://doaj.org/article/bed96d5567674d73b17dcc007f16421b
Autor:
Natsue Kishida, Takakuni Maki, Yasushi Takagi, Ken Yasuda, Hisanori Kinoshita, Takashi Ayaki, Takayuki Noro, Yusuke Kinoshita, Yuichi Ono, Hiroharu Kataoka, Kazumichi Yoshida, Eng H. Lo, Ken Arai, Susumu Miyamoto, Ryosuke Takahashi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 9 (2019)
Background Oligodendrocyte precursor cells (OPCs) regulate neuronal, glial, and vascular systems in diverse ways and display phenotypic heterogeneity beyond their established role as a reservoir for mature oligodendrocytes. However, the detailed phen
Externí odkaz:
https://doaj.org/article/ef5956e8d804407fb6a0b7b4877a9c97