Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Takashi Shimoaka"'
Autor:
Hiroshi Kawaguchi, Takashi Shimoaka, Hirotaka Chikuda, Takashi Yamada, Kazuto Hoshi, M. Uchida, Ung-il Chung, Satoru Kamekura, Kozo Nakamura, Atsushi Seichi, Naoshi Ogata
Publikováno v:
Osteoarthritis and Cartilage. 13:632-641
Summary Objective Although osteoarthritis (OA) is induced by accumulated mechanical stress to joints, little is known about the underlying molecular mechanism. To apply approaches from mouse genomics, this study created experimental mouse OA models b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f12bc71588f4ebd581e80da1d562b2d
https://doi.org/10.1016/j.joca.2005.03.004
https://doi.org/10.1016/j.joca.2005.03.004
Autor:
Kajuro Komeda, Atsuko Tsuchida, Hiroshi Kawaguchi, Hirotaka Chikuda, Takashi Shimoaka, Toru Ogasawara, Satoru Kamekura, Toshiyuki Ikeda, Norihide Yokoi, Hirotaka Kawano, Kazuto Hoshi, Fumitaka Kugimiya, Kozo Nakamura, Ung-il Chung
Publikováno v:
Genes & Development. 18:2418-2429
The Komeda miniature rat Ishikawa (KMI) is a naturally occurring mutant caused by an autosomal recessive mutation mri, which exhibits longitudinal growth retardation. Here we identified the mri mutation as a deletion in the rat gene encoding cGMP-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a55c60d627edc8750af88763426bb2
https://doi.org/10.1101/gad.1224204
https://doi.org/10.1101/gad.1224204
Autor:
Wataru Ogawa, Michihiro Matsumoto, Kazuto Hoshi, Satoru Kamekura, Hiroshi Kawaguchi, Ung-il Chung, Toru Akune, Zenjiro Maruyama, Kozo Nakamura, Takashi Kadowaki, Hirotaka Chikuda, Takashi Shimoaka, Yasuo Terauchi, Toshihisa Komori
Publikováno v:
Journal of Biological Chemistry. 279:15314-15322
Insulin receptor substrate-1 (IRS-1) is an essential molecule for intracellular signaling of insulin-like growth factor (IGF)-I and insulin, both of which are potent anabolic regulators of bone and cartilage metabolism. To investigate the role of IRS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6a3ab0ae8c7c9dafea4f326f4e5a2f
https://doi.org/10.1074/jbc.m312525200
https://doi.org/10.1074/jbc.m312525200
Autor:
Hidehiro Ozawa, Hiroshi Kawaguchi, Kazuto Hoshi, Masakazu Iwasaka, Hiroko Kotani, Shoogo Ueno, Kozo Nakamura, Takashi Shimoaka
Publikováno v:
Journal of Bone and Mineral Research. 17:1814-1821
The induction of bone formation to an intentional orientation is a potentially viable clinical treatment for bone disorders. Among the many chemical and physical factors, a static magnetic field (SMF) of tesla order can regulate the shapes of blood c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94aa204212c6df5bf67685e203b229a5
https://doi.org/10.1359/jbmr.2002.17.10.1814
https://doi.org/10.1359/jbmr.2002.17.10.1814
Autor:
Toru Ogasawara, Takashi Shimoaka, Mika Katagiri, Daichi Chikazu, Kozo Nakamura, Tsuyoshi Takato, Hiroshi Kawaguchi, Naoshi Ogata
Publikováno v:
Journal of Bone and Mineral Research. 16:2074-2081
This study investigated the mechanism of direct and indirect actions of fibroblast growth factor 2 (FGF-2) on osteoclast differentiation using two mouse cell culture systems. In the coculture system of osteoblasts and bone marrow cells, FGF-2 stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30dc084edd49efe106ea306dce1a563
https://doi.org/10.1359/jbmr.2001.16.11.2074
https://doi.org/10.1359/jbmr.2001.16.11.2074
Autor:
Kozo Nakamura, Shingo Sato, Takashi Shimoaka, Toshihisa Komori, Satoru Kamekura, Ung-il Chung, Kazuto Hoshi, Hirotaka Chikuda, Yosuke Kawasaki, Shu Takeda, Hiroshi Kawaguchi, Zenjiro Maruyama, Gerard Karsenty
Publikováno v:
Arthritis and rheumatism. 54(8)
Objective By producing instability in mouse knee joints, we attempted to determine the involvement of runt-related transcription factor 2 (RUNX-2), which is required for chondrocyte hypertrophy, in the development of osteoarthritis (OA). Methods An e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2694badbc637d4ac5f2a76453fb75891
https://pubmed.ncbi.nlm.nih.gov/16868966
https://pubmed.ncbi.nlm.nih.gov/16868966
Autor:
Kozo Nakamura, Yasuo Terauchi, Ung-il Chung, Shin-ichi Kenmotsu, Hedehiro Ozawa, Takashi Shimoaka, Takashi Kadowaki, Hiroshi Kawaguchi, Kazuto Hoshi, Naoshi Ogata
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 19(2)
Morphological analyses in and around the epiphyseal cartilage of mice deficient in insulin receptor substrate-1 (IRS-1) showed IRS-1 signaling to be important for skeletal growth by preventing early closure of the epiphyseal cartilage and maintaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dc0a57f4e179b40a6bec821ff0233d
https://pubmed.ncbi.nlm.nih.gov/14969391
https://pubmed.ncbi.nlm.nih.gov/14969391
Autor:
Nobuyuki Itoh, Hirotaka Kawano, Hiroshi Kawaguchi, Akiko Yonamine, Daichi Chikazu, Takashi Shimoaka, Kozo Nakamura, Toru Ogasawara
Publikováno v:
The Journal of biological chemistry. 277(9)
This study investigated the actions of fibroblast growth factor (FGF)-18, a novel member of the FGF family, on osteoblasts, chondrocytes, and osteoclasts and compared them with those of FGF-2 and FGF-10. FGF-18 stimulated the proliferation of culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed0336dc63626fc72087a5cef8f5bd5
https://pubmed.ncbi.nlm.nih.gov/11741978
https://pubmed.ncbi.nlm.nih.gov/11741978
Autor:
Hiroyuki Suzuki, Kazumi Obara, Hideyuki Yamato, Yumiko Nagai, Takashi Shimoaka, Hiroshi Kawaguchi, Motoyuki Uchida, Toshiyuki Ikeda, Masaaki Shima, Ayako Fujieda
Publikováno v:
Journal of cellular physiology. 185(2)
In addition to their stimulating function on osteoclastic bone resorption, bone resorptive factors may regulate proteinases and related factors in osteoblastic cells to degrade bone matrix proteins. This study investigated the regulation of matrix me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aac500095e16c80b1392d6f7e9b8f4c
https://pubmed.ncbi.nlm.nih.gov/11025442
https://pubmed.ncbi.nlm.nih.gov/11025442
Autor:
Satoru Kamekura, Yosuke Kawasaki, Kazuto Hoshi, Takashi Shimoaka, Hirotaka Chikuda, Zenjiro Maruyama, Toshihisa Komori, Shingo Sato, Shu Takeda, Gerard Karsenty, Kozo Nakamura, Ung‐il Chung, Hiroshi Kawaguchi
Publikováno v:
Arthritis & Rheumatism; Aug2006, Vol. 54 Issue 8, p2462-2470, 9p