Zobrazeno 1 - 10
of 2 904
pro vyhledávání: '"Takashi Saito"'
Autor:
Akira Sobue, Okiru Komine, Fumito Endo, Chihiro Kakimi, Yuka Miyoshi, Noe Kawade, Seiji Watanabe, Yuko Saito, Shigeo Murayama, Takaomi C. Saido, Takashi Saito, Koji Yamanaka
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-14 (2024)
Abstract Alzheimer’s disease (AD) is the most common form of dementia and is characterized by the accumulation of amyloid β (Aβ) and phosphorylated tau. Neuroinflammation, mainly mediated by glial activation, plays an important role in AD progres
Externí odkaz:
https://doaj.org/article/ccc319a907c149fd965fc867b0286b32
Autor:
Yuko Matsui, Satoshi Higuchi, Fumiaki Mori, Kao Takehisa, Kensuke Kikuchi, Haruka Kikuchi, Kohei Hirobe, Ryozo Maeda, Kei Tsukamoto, Takashi Saito, Morio Shoda, Junichi Yamaguchi
Publikováno v:
Journal of Arrhythmia, Vol 40, Iss 5, Pp 1150-1157 (2024)
Abstract Background Various surgical procedures have employed microporous polysaccharide hemosphere (MPH) hemostatic agents. However, data regarding their effectiveness in preventing pocket hematomas (PHs) during the implantation of cardiac implantab
Externí odkaz:
https://doaj.org/article/2e9648cece51429597e890eea98eb19d
Autor:
Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Takashi Saito, Takaomi C. Saido, Shuji Wakatsuki, Toshiyuki Araki
Publikováno v:
Neuroscience Research, Vol 205, Iss , Pp 40-46 (2024)
Sleep apnea is regarded as an important risk factor in the pathogenesis of Alzheimer disease (AD). Chronic intermittent hypoxia treatment (IHT) given during the sleep period of the circadian cycle in experimental animals is a well-established sleep a
Externí odkaz:
https://doaj.org/article/2970af987d6f457b9f2fbe1bf4d1e0a0
Autor:
Keiko Honda, Hiroo Takahashi, Saori Hata, Ruriko Abe, Takashi Saito, Takaomi C. Saido, Hidenori Taru, Yuriko Sobu, Kanae Ando, Tohru Yamamoto, Toshiharu Suzuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Generation and accumulation of amyloid-β (Aβ) protein in the brain are the primary causes of Alzheimer’s disease (AD). Alcadeins (Alcs composed of Alcα, Alcβ and Alcγ family) are a neuronal membrane protein that is subject to proteoly
Externí odkaz:
https://doaj.org/article/558d723416ea4db3b6ab826b46b13cb7
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-23 (2024)
Abstract Mesenchymal stem cells (MSCs) may be effective in treating connective tissue disease and associated organ damage, leveraging their anti-inflammatory and immunoregulatory effects. Moreover, MSCs may possess the ability to produce antiapoptoti
Externí odkaz:
https://doaj.org/article/303e945bf04f4f38ba1866eb6e9d3eca
Autor:
Masashi Mizumoto, Sho Hosaka, Kei Nakai, Yinuo Li, Yoshiko Oshiro, Takashi Iizumi, Takashi Saito, Masako Inaba, Hiroko Fukushima, Ryoko Suzuki, Shosei Shimizu, Kazushi Maruo, Hideyuki Sakurai
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40372- (2024)
Introduction: Proton beam therapy (PBT) may reduce the number of adverse events in treatment of patients with pediatric cancer. However, it is difficult to evaluate whether the actual therapeutic effect is truly equivalent to that of photon radiother
Externí odkaz:
https://doaj.org/article/ebf208c1047e4c448e538a6a18e222c2
Autor:
Stephanie R. Miller, Kevin Luxem, Kelli Lauderdale, Pranav Nambiar, Patrick S. Honma, Katie K. Ly, Shreya Bangera, Mary Bullock, Jia Shin, Nick Kaliss, Yuechen Qiu, Catherine Cai, Kevin Shen, K. Dakota Mallen, Zhaoqi Yan, Andrew S. Mendiola, Takashi Saito, Takaomi C. Saido, Alexander R. Pico, Reuben Thomas, Erik D. Roberson, Katerina Akassoglou, Pavol Bauer, Stefan Remy, Jorge J. Palop
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114870- (2024)
Summary: Computer-vision and machine-learning (ML) approaches are being developed to provide scalable, unbiased, and sensitive methods to assess mouse behavior. Here, we used the ML-based variational animal motion embedding (VAME) segmentation platfo
Externí odkaz:
https://doaj.org/article/624d2d95b9884a1bbb7878c8a321d192
Autor:
Akiko Hashimoto-Tane, Edward P. Bowman, Machie Sakuma, Natsumi Yoneda, Katsuyuki Yugi, Rene de Waal Malefyt, Takashi Saito
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lymphocyte activation gene (Lag)-3 is an inhibitory co-receptor and target of immune checkpoint inhibitor (ICI) therapy for cancer. The dynamic behavior of Lag-3 was analyzed at the immune synapse upon T-cell activation to elucidate the Lag-3 inhibit
Externí odkaz:
https://doaj.org/article/01488bb5ac8c4a6ab38ab7b584d9ff15
Autor:
Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Takaomi C. Saido, Takashi Saito, Koji Yamanaka
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Neuroinflammation substantially contributes to the pathology of Alzheimer’s disease (AD), the most common form of dementia. Studies have reported that nuclear factor erythroid 2-related factor 2 (Nrf2) attenuates neuroinflammati
Externí odkaz:
https://doaj.org/article/8faa1d5d1ab24c86b2133cd8308b52a7
Publikováno v:
Children, Vol 11, Iss 9, p 1084 (2024)
Background/Objectives: Engaging in physical activity (PA) is crucial for children’s physical and mental health, with PA in childhood influencing lifelong activity levels. However, PA during childhood tends to decrease with age. Childhood friendship
Externí odkaz:
https://doaj.org/article/aff7702a284741a5af215dc02a8c1f84