Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Takashi, Mizuma"'
Publikováno v:
Chem-Bio Informatics Journal. 17:103-109
Autor:
Shingo Takatori, Marina Shigematsu, Hiroaki Araki, Hiroshi Kimura, Shinichi Watanabe, Akihiro Tanaka, Takashi Mizuma, Mamoru Tanaka
Publikováno v:
Therapeutic Drug Monitoring. 39:614-616
The performance of a population pharmacokinetic model in predicting trough concentrations after the initial vancomycin dose was evaluated in patients with albuminuria compared with patients who did not have albuminuria.Data were collected from 52 pat
Publikováno v:
Journal of Pharmaceutical Sciences. 102:3447-3450
Drug toxicity impedes drug development and its clinical use. In the present study, a toxicity risk index (TRI), which is an index for warning idiosyncratic drug toxicity (IDT), was proposed. The TRI of drugs was defined as a function of dose, pharmac
Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development
Autor:
Takashi Mizuma
Publikováno v:
Journal of Pharmaceutical Sciences. 99:1078-1086
Although prodrugging (prodrug derivatization) is a powerful technique for improving the pharmacokinetic characteristics of drugs, the intestinal pharmacokinetics of prodrugs has yet to be elucidated fully. A previous article reported the kinetic requ
Autor:
Takashi Mizuma
Publikováno v:
Folia Pharmacologica Japonica. 134:142-145
腸管代謝は経口薬が循環血中に入るまでの初期に起こる過程であり,吸収率,肝アベイラビリティとともに重要な因子である.近年,腸管のCYP3Aによる第I相酸化代謝が経口バイオアベイ
Autor:
Takashi Mizuma
Publikováno v:
Chem-Bio Informatics Journal. 8:25-32
Chemical modification of an active drug with promoiety to a prodrug (“prodrugging”) is a way to improve the pharmacokinetic characteristics of an active drug in the body; however, no kinetic principles have been proposed to design orally effectiv
Autor:
Takashi Mizuma
Publikováno v:
Chem-Bio Informatics Journal. 8:58-68
Because no kinetic principles have been proposed for designing orally effective prodrugs, the author recently reported a kinetic model for membrane transport of prodrugs (Chem-Bio Informatics Journal, 8, 25-32 (2008)), and proposed the kinetic classi
Autor:
Takashi Mizuma
Publikováno v:
Drug Delivery System. 21:126-133
糖トランスポーターを利用したDDSについて, これまでの知見をまとめた. 糖トランスポーターを利用した“薬物”のデリバリーの報告例は少ない. 腸管においては, SGLT1を介した各種グリコ
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 28:1531-1537
A high performance liquid chromatographic assay method was established to simultaneously determine lenampicillin (ampicillin prodrug), ampicillin, and an absorption marker compound (antipyrine) for the high‐throughput in vitro assessment of intesti
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:661-664
Glycosidase activity influences the intestinal absorption of glycosides. Our previous study in rats suggested that disaccharide conjugates might be prototypes for pre-prodrugs aiming at the Na+/ glucose co-transporter-mediated transport of prodrugs (