Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Takashi, Iezaki"'
Autor:
Satoru Demura, Eiichi Hinoi, Noriaki Kawakami, Makoto Handa, Noriaki Yokogawa, Manami Hiraiwa, Satoshi Kato, Kazuya Shinmura, Takaki Shimizu, Norihiro Oku, Ryohei Annen, Motoya Kobayashi, Yohei Yamada, Satoshi Nagatani, Takashi Iezaki, Yuki Taniguchi, Hiroyuki Tsuchiya
Publikováno v:
Spine Surgery and Related Research, Vol 6, Iss 4, Pp 402-407 (2022)
Introduction: Amino acid transporters are transmembrane proteins that are known to mediate the transfer of amino acids. As one of the amino acid transporters, LAT1, which is encoded by Slc7a5, mediates the cellular uptake of the essential amino acids
Externí odkaz:
https://doaj.org/article/bed056206ed544c2b9118085d3105223
Autor:
Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Yusuke Masuo, Yuka Inaba, Takanori Tatsuno, Takanori Yamada, Kazuya Tokumura, Sayuki Iwahashi, Takashi Iezaki, Katsuyuki Kaneda, Yukio Kato, Yasuhito Ishigaki, Michihiro Mieda, Tomohiro Tanaka, Kazuma Ogawa, Hiroki Ochi, Shingo Sato, Yun-Bo Shi, Hiroshi Inoue, Hojoon Lee, Eiichi Hinoi
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Hypothalamic neurons regulate body homeostasis by sensing and integrating changes in the levels of key hormones and primary nutrients (amino acids, glucose, and lipids). However, the molecular mechanisms that enable hypothalamic neurons to detect pri
Externí odkaz:
https://doaj.org/article/69274c6ccd734fd68d05813f708b0c90
Autor:
Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, Gyujin Park, Katsuyuki Kaneda, Tomoki Todo, Atsushi Hirao, Mitsutoshi Nakada, Eiichi Hinoi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Hiraiwa et al. show that phosphorylation of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) at Thr249 mediates ubiquitylation and degradation of the TGF-β receptor TGBR1 leading to loss of glioblastoma stem cell tumorigenic capacity. Their data
Externí odkaz:
https://doaj.org/article/947620c5dbce49479302679a911d0d45
Autor:
Shinsuke Ochiai, Kazuya Tokumura, Gyujin Park, Kakeru Ozaki, Tetsuhiro Horie, Takanori Yamada, Sayuki Iwahashi, Kaname Ohta, Hiroki Fusawa, Yasuka Okayama, Katsuyuki Kaneda, Takashi Iezaki, Eiichi Hinoi
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 1-5 (2021)
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailt
Externí odkaz:
https://doaj.org/article/8bb19e32b3b8492a93d071b9d27caabe
Autor:
Takashi Iezaki, Tetsuhiro Horie, Kazuya Fukasawa, Makoto Kitabatake, Yuka Nakamura, Gyujin Park, Yuki Onishi, Kakeru Ozaki, Takashi Kanayama, Manami Hiraiwa, Yuka Kitaguchi, Katsuyuki Kaneda, Takayuki Manabe, Yasuhito Ishigaki, Mutsuhito Ohno, Eiichi Hinoi
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Summary: The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs
Externí odkaz:
https://doaj.org/article/a74140fb7e634b20b5faa27345d65c2c
Autor:
Sayuki Iwahashi, Jiajun Lyu, Kazuya Tokumura, Ryoma Osumi, Manami Hiraiwa, Takuya Kubo, Tetsuhiro Horie, Satoru Demura, Noriaki Kawakami, Taku Saito, Gyujin Park, Kazuya Fukasawa, Takashi Iezaki, Akane Suzuki, Akane Tomizawa, Hiroki Ochi, Hironori Hojo, Shinsuke Ohba, Eiichi Hinoi
Publikováno v:
Journal of Cellular Physiology. 237:4292-4302
Scoliosis, usually diagnosed in childhood and early adolescence, is an abnormal lateral curvature of the spine. L-type amino acid transporter 1 (LAT1), encoded by solute carrier transporter 7a5 (Slc7a5), plays a crucial role in amino acid sensing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2cda1add0dc93d47f653c22f0a29cc
https://doi.org/10.1002/jcp.30883
https://doi.org/10.1002/jcp.30883
Autor:
Manami Hiraiwa, Kakeru Ozaki, Takanori Yamada, Takashi Iezaki, Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Hikari Kamada, Kazuya Tokumura, Mei Motono, Katsuyuki Kaneda, Eiichi Hinoi
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The mechanistic/mammalian target of rapamycin (mTOR) is widely implicated in the pathogenesis of various diseases, including cancer, obesity, and cardiovascular disease. Bone homeostasis is maintained by the actions of bone-resorbing osteoclasts and
Externí odkaz:
https://doaj.org/article/77d5728b82864ecfb103a2d6f83a5a78
Autor:
Takashi Iezaki, Kazuya Fukasawa, Takanori Yamada, Manami Hiraiwa, Katsuyuki Kaneda, Eiichi Hinoi
Publikováno v:
Bio-Protocol, Vol 9, Iss 1 (2019)
Mesenchymal stem cells have the ability to differentiate into multiple lineages, including adipocytes, osteoblasts and chondrocytes. Mesenchymal stem cells can be induced to differentiate into chondrocytes in extracellular matrices, such as alginate
Externí odkaz:
https://doaj.org/article/34ca24adb829480b9e73dc835aaede93
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 216-223 (2016)
We previously demonstrated a marked upregulation in the bone morphogenic protein (BMP)/growth differentiation factor (GDF) family member, GDF5, which is capable of promoting brown adipogenesis, in brown adipose tissue (BAT) of obese mice. In this stu
Externí odkaz:
https://doaj.org/article/cf484434d96a4c9f8b6ef16305eab2a6
Autor:
Tetsuhiro Horie, Kazuya Fukasawa, Takanori Yamada, Seiya Mizuno, Takashi Iezaki, Kazuya Tokumura, Sayuki Iwahashi, Shiho Sakai, Akane Suzuki, Takuya Kubo, Ryoma Osumi, Akane Tomizawa, Hiroki Ochi, Shingo Sato, Katsuyuki Kaneda, Satoru Takahashi, Eiichi Hinoi
Publikováno v:
Stem Cells. 40:411-422
Extracellular signal-regulated kinase 5 (Erk5) belongs to the mitogen-activated protein kinase (MAPK) family. Previously, we demonstrated that Erk5 directly phosphorylates Smad-specific E3 ubiquitin protein ligase 2 (Smurf2) at Thr249 (Smurf2Thr249)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702abd4941b4cbec48ce3e6f8c4bebaf
https://doi.org/10.1093/stmcls/sxac011
https://doi.org/10.1093/stmcls/sxac011