Synthesis of difluoromethylated diarylmethanes via Fe(OTf)3-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates

Autor: Yamamoto, Yoshihiko, Takase, Tomoya, Kuroyanagi, Eisuke, Yasui, Takeshi

Publikováno v: Chemical Communications. 57(32):3877-3880

The Fe(OTf)3-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates with electron-rich (hetero)arenes afforded difluoromethylated diarylmethanes. Control experiments showed that Fe(OTf)3 behaves as the Lewis acid, and that the pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::f618bfe3bf57a6c77d28bc553fe81974
https://nagoya.repo.nii.ac.jp/records/2001581

Synthesis of difluoromethylated diarylmethanes via Fe(OTf) 3 -catalyzed Friedel-Crafts reaction of 2,2-difluoro-1-arylethyl phosphates.

Autor: Yamamoto Y; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. yamamoto-yoshi@ps.nagoya-u.ac.jp., Takase T; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. yamamoto-yoshi@ps.nagoya-u.ac.jp., Kuroyanagi E; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. yamamoto-yoshi@ps.nagoya-u.ac.jp., Yasui T; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. yamamoto-yoshi@ps.nagoya-u.ac.jp.

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Apr 25; Vol. 57 (32), pp. 3877-3880. Date of Electronic Publication: 2021 Mar 22.