Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Takaomi Sanda"'
Autor:
Sinan Xiong, Jianbiao Zhou, Tze King Tan, Tae-Hoon Chung, Tuan Zea Tan, Sabrina Hui-Min Toh, Nicole Xin Ning Tang, Yunlu Jia, Yi Xiang See, Melissa Jane Fullwood, Takaomi Sanda, Wee-Joo Chng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Multiple myeloma is a hematological malignancy arising from immunoglobulin-secreting plasma cells. It remains poorly understood how chromatin rewiring of regulatory elements contributes to tumorigenesis and therapy resistance in myeloma. Her
Externí odkaz:
https://doaj.org/article/a72d588788c3426aa48efeac9ff0d625
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113541- (2023)
Summary: Neuroblastoma originates from developing neural crest and can interconvert between the mesenchymal (MES) and adrenergic (ADRN) states, each of which are controlled by different sets of transcription factors forming the core regulatory circui
Externí odkaz:
https://doaj.org/article/c9688bf24836492f9b226b8aa8d73946
Autor:
Jianbiao Zhou, Sabrina Hui-Min Toh, Tze King Tan, Kalpnaa Balan, Jing Quan Lim, Tuan Zea Tan, Sinan Xiong, Yunlu Jia, Siok-Bian Ng, Yanfen Peng, Anand D. Jeyasekharan, Shuangyi Fan, Soon Thye Lim, Chin-Ann Johnny Ong, Choon Kiat Ong, Takaomi Sanda, Wee-Joo Chng
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-20 (2023)
Abstract Background Extranodal natural killer/T-cell lymphoma (NKTL) is an aggressive type of non-Hodgkin lymphoma with dismal outcome. A better understanding of disease biology and key oncogenic process is necessary for the development of targeted t
Externí odkaz:
https://doaj.org/article/846e95d9de9a442a8d6a7330386245b8
Publikováno v:
Haematologica, Vol 109, Iss 5 (2023)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy derived from thymic T-cell precursors. Approximately 40-60% of T-ALL cases exhibit aberrant overexpression of the TAL1 oncogenic transcription factor. Here, we provide a comprehe
Externí odkaz:
https://doaj.org/article/431d29fc83c9404bad1fc84a3bbeaab0
Autor:
Takayoshi Matsumura, Haruhito Totani, Yoshitaka Gunji, Masahiro Fukuda, Rui Yokomori, Jianwen Deng, Malini Rethnam, Chong Yang, Tze King Tan, Tadayoshi Karasawa, Kazuomi Kario, Masafumi Takahashi, Motomi Osato, Takaomi Sanda, Toshio Suda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The transcription factor MYB has been shown to regulate haematopoietic stem cells but there could be lineage specific enhancers. Here, using lineage tracing and single cell sequencing the authors characterise a Myb −68 enhancer that regulates the d
Externí odkaz:
https://doaj.org/article/f7b34ab06eff47b1947cf8949cde1d29
Autor:
Stella Amanda, Tze King Tan, Jolynn Zu Lin Ong, Madelaine Skolastika Theardy, Regina Wan Ju Wong, Xiao Zi Huang, Muhammad Zulfaqar Ali, Yan Li, Zhiyuan Gong, Hiroshi Inagaki, Ee Yong Foo, Brendan Pang, Soo Yong Tan, Shinsuke Iida, Takaomi Sanda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
IRF4 is a regulator of immune function, and is overexpressed in lymphoid neoplasms. Here, the authors utilise single cell RNA-seq to show the abundance of double-negative T cells in IRF4 driven zebrafish tumour models, and identify sensitivity of the
Externí odkaz:
https://doaj.org/article/ff3debb04d284c5488577eed6625143c
Autor:
Tomotaka Suzuki, Rui Yokomori, Takaomi Sanda, Takaki Kikuchi, Yoshiaki Marumo, Shiori Kinoshita, Tomoko Narita, Ayako Masaki, Asahi Ito, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Hiroshi Inagaki, Shinsuke Iida
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
We report a 69-year-old female who was a human T-cell leukemia virus type 1 carrier and exhibited a unique clinical course of developing three hematological malignancies within a short period: diffuse large B-cell lymphoma (DLBCL), chronic myelomonoc
Externí odkaz:
https://doaj.org/article/8aba716dd1a04644967bae0b971ebc08
Autor:
Fang Qi Lim, Allison Si-Yu Chan, Rui Yokomori, Xiao Zi Huang, Madelaine Skolastika Theardy, Allen Eng Juh Yeoh, Shi Hao Tan, Takaomi Sanda
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy of thymic T-cell precursors. Overexpression of oncogenic transcription factor TAL1 is observed in 40-60% of human T-ALL cases, frequently together with activation of the NOTCH1 and PI3K-AKT
Externí odkaz:
https://doaj.org/article/41fbefeee4bf462ca1a3441c3663a321
Autor:
Yunlu Jia, Jianbiao Zhou, Tze King Tan, Tae-Hoon Chung, Regina Wan Ju Wong, Jing-Yuan Chooi, Julia Sze Lynn Lim, Takaomi Sanda, Melissa Ooi, Sanjay De Mel, Cinnie Soekojo, Yongxia Chen, Enfan Zhang, Zhen Cai, Peng Shen, Jian Ruan, Wee-Joo Chng
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 2, Pp 1-13 (2021)
Abstract Multiple myeloma (MM) is an aggressive plasma cell neoplasm characterized by genomic heterogeneity. Superenhancers (SEs) are defined as large clusters of enhancers in close genomic proximity, which regulate genes for maintaining cellular ide
Externí odkaz:
https://doaj.org/article/84a9518ee10c44cc91668e7428907d28
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/63c8edc69def49af87c84551a1d9fe30