Výsledky vyhledávání - "Takaomi Ishida"

Akademický článek

BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

Autor: Jin Gohda, Kazuo Suzuki, Kai Liu, Xialin Xie, Hiroaki Takeuchi, Jun-ichiro Inoue, Yasushi Kawaguchi, Takaomi Ishida

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Abstract HIV-1 latent reservoirs harbouring silenced but replication-competent proviruses are a major obstacle against viral eradication in infected patients. The “shock and kill” strategy aims to reactivate latent provirus with latency reversing

Externí odkaz: https://doaj.org/article/d37f295b182b40f49c519bc38e7232db

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Akademický článek

Emergence of Lamivudine-Resistant HBV during Antiretroviral Therapy Including Lamivudine for Patients Coinfected with HIV and HBV in China.

Autor: Lijun Gu, Yang Han, Yijia Li, Ting Zhu, Xiaojing Song, Ying Huang, Feifei Yang, Shuo Guan, Jing Xie, Jin Gohda, Noriaki Hosoya, Ai Kawana-Tachikawa, Wenjun Liu, George Fu Gao, Aikichi Iwamoto, Taisheng Li, Takaomi Ishida

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134539 (2015)

In China, HIV-1-infected patients typically receive antiretroviral therapy (ART) that includes lamivudine (3TC) as a reverse-transcriptase inhibitor (RTI) (ART-3TC). Previous studies from certain developed countries have shown that, in ART-3TC, 3TC-r

Externí odkaz: https://doaj.org/article/216c82b675544a2aa0cef6cdbd61c0b6

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Akademický článek

Development and customization of a color-coded microbeads-based assay for drug resistance in HIV-1 reverse transcriptase.

Autor: Lijun Gu, Ai Kawana-Tachikawa, Teiichiro Shiino, Hitomi Nakamura, Michiko Koga, Tadashi Kikuchi, Eisuke Adachi, Tomohiko Koibuchi, Takaomi Ishida, George F Gao, Masaki Matsushita, Wataru Sugiura, Aikichi Iwamoto, Noriaki Hosoya

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109823 (2014)

BACKGROUND: Drug resistance (DR) of HIV-1 can be examined genotypically or phenotypically. Although sequencing is the gold standard of the genotypic resistance testing (GRT), high-throughput GRT targeted to the codons responsible for DR may be more a

Externí odkaz: https://doaj.org/article/fd606701257a452080916c4259f4048a

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Akademický článek

Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing

Autor: Kazuo Suzuki, Shinichiro Hattori, Katherine Marks, Chantelle Ahlenstiel, Yosuke Maeda, Takaomi Ishida, Michelle Millington, Maureen Boyd, Geoff Symonds, David A Cooper, Seiji Okada, Anthony D Kelleher

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)

Despite prolonged and intensive application, combined antiretroviral therapy cannot eradicate human immunodeficiency virus (HIV)-1 because it is harbored as a latent infection, surviving for long periods of time. Alternative approaches are required t

Externí odkaz: https://doaj.org/article/373f6ecfe7794fecaf0be6afb73a9de8

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Elevation of cell-associated HIV-1 transcripts in CSF CD4+ T cells, despite effective antiretroviral therapy, is linked to brain injury

Autor: Kazuo Suzuki, John Zaunders, Thomas M. Gates, Angelique Levert, Shannen Butterly, Zhixin Liu, Takaomi Ishida, Sarah Palmer, Caroline D. Rae, Lauriane Jugé, Lucette A. Cysique, Bruce J. Brew

Publikováno v: Proceedings of the National Academy of Sciences. 119

Antiretroviral therapy (ART) can attain prolonged undetectable HIV-1 in plasma and cerebrospinal fluid (CSF), but brain injury remains prevalent in people living with HIV-1 infection (PLHIV). We investigated cell-associated (CA)-HIV-1 RNA transcripts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7801baa8653f0c7488ec8ef4682c908f
https://doi.org/10.1073/pnas.2210584119

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Identification and characterization of Stathmin 1 as a host factor involved in HIV-1 latency

Autor: Hiroaki Takeuchi, Takaomi Ishida, Haruki Kitamura, Jin Gohda, Selase D. Deletsu, Shoji Yamaoka

Publikováno v: Biochemical and Biophysical Research Communications. 567:106-111

Latency remains a barrier to achieving a sterilizing cure to HIV infection. It is thus important to find new host factor(s) to better understand maintenance of HIV latency and be exploited to develop new and more efficient latency reversing agents (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d3e3ae669ddf3539bc3bcab8f53f6
https://doi.org/10.1016/j.bbrc.2021.06.017

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