Zobrazeno 1 - 10
of 677
pro vyhledávání: '"Takaomi C, Saido"'
Autor:
Keiko Honda, Hiroo Takahashi, Saori Hata, Ruriko Abe, Takashi Saito, Takaomi C. Saido, Hidenori Taru, Yuriko Sobu, Kanae Ando, Tohru Yamamoto, Toshiharu Suzuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Generation and accumulation of amyloid-β (Aβ) protein in the brain are the primary causes of Alzheimer’s disease (AD). Alcadeins (Alcs composed of Alcα, Alcβ and Alcγ family) are a neuronal membrane protein that is subject to proteoly
Externí odkaz:
https://doaj.org/article/558d723416ea4db3b6ab826b46b13cb7
Autor:
Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Takaomi C. Saido, Takashi Saito, Koji Yamanaka
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Neuroinflammation substantially contributes to the pathology of Alzheimer’s disease (AD), the most common form of dementia. Studies have reported that nuclear factor erythroid 2-related factor 2 (Nrf2) attenuates neuroinflammati
Externí odkaz:
https://doaj.org/article/8faa1d5d1ab24c86b2133cd8308b52a7
Autor:
Laura Wieg, Jason C. Ciola, Caroline C. Wasén, Fidelia Gaba, Brianna R. Colletti, Maren K. Schroeder, Robert G. Hinshaw, Millicent N. Ekwudo, David M. Holtzman, Takashi Saito, Hiroki Sasaguri, Takaomi C. Saido, Laura M. Cox, Cynthia A. Lemere
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9379 (2024)
Cosmic radiation experienced during space travel may increase the risk of cognitive impairment. While simulated galactic cosmic radiation (GCRsim) has led to memory deficits in wildtype (WT) mice, it has not been investigated whether GCRsim in combin
Externí odkaz:
https://doaj.org/article/1d54f1557c004e96900c2809e2acba91
Autor:
Lidia Sánchez-Puebla, Rosa de Hoz, Elena Salobrar-García, Alberto Arias-Vázquez, María González-Jiménez, Ana I. Ramírez, José A. Fernández-Albarral, José A. Matamoros, Lorena Elvira-Hurtado, Takaomi C. Saido, Takashi Saito, Carmen Nieto Vaquero, María I. Cuartero, María A. Moro, Juan J. Salazar, Inés López-Cuenca, José M. Ramírez
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8221 (2024)
In Alzheimer’s disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APPNL-F/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients
Externí odkaz:
https://doaj.org/article/3ce6abd2cda9437d8823ac4665dff182
Autor:
Lidia Sánchez-Puebla, Inés López-Cuenca, Elena Salobrar-García, María González-Jiménez, Alberto Arias-Vázquez, José A. Matamoros, Ana I. Ramírez, José A. Fernández-Albarral, Lorena Elvira-Hurtado, Takaomi C. Saido, Takashi Saito, Carmen Nieto-Vaquero, María I. Cuartero, María A. Moro, Juan J. Salazar, Rosa de Hoz, José M. Ramírez
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 828 (2024)
Alzheimer’s disease (AD) may manifest retinal changes preceding brain pathology. A transversal case-control study utilized spectral-domain OCT angiography (SD-OCTA) and Angio-Tool software 0.6a to assess retinal vascular structures and OCT for inne
Externí odkaz:
https://doaj.org/article/bceffc28deb94c739883335509abc02b
Autor:
Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian, Jingjing Sun, Guangxin Sun, Sherif Rashad, Caroline Kornbrek, Sarah Anne Daley, Peter C. Dedon, Brian Nguyen, Weiming Xia, Takashi Saito, Takaomi C. Saido, Benjamin Wolozin
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionThe study of the pathophysiology study of Alzheimer’s disease (AD) has been hampered by lack animal models that recapitulate the major AD pathologies, including extracellular -amyloid (A) deposition, intracellular aggregation of microtu
Externí odkaz:
https://doaj.org/article/b7557e4ad4e346968ea1ea10bd07ae48
Autor:
Suzuko Ochi, Kumiko Yamada, Takashi Saito, Takaomi C. Saido, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kubo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionAlzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (Aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognit
Externí odkaz:
https://doaj.org/article/5fcf8d1ccf79443b89280e07717274de
Autor:
Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Satoru Kawamura, Eri Wakai, Tsuyoshi Miyoshi, Takashi Sato, Yumi Ohta, Takashi Saito, Takaomi C. Saido, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/cf37a8eb5b964041adb735ddaa9ddbf9
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
Waka Sato, Miho Watanabe-Takahashi, Takuya Murata, Naoko Utsunomiya-Tate, Jun Motoyama, Masataka Anzai, Seiko Ishihara, Nanako Nishioka, Hina Uchiyama, Juri Togashi, Saeka Nishihara, Kiyoshi Kawasaki, Takashi Saito, Takaomi C. Saido, Satoru Funamoto, Kiyotaka Nishikawa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Multivalent peptide library screens identify a tetravalent peptide that binds APP and A β via multivalent interactions and reduces A β in the brains of Alzheimer’s disease model mice.
Externí odkaz:
https://doaj.org/article/18881887888349608aa45d5d46a40371