Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Takaomi, Hagi"'
Autor:
Rony Takchi, Bethany C. Prudner, Qingqing Gong, Takaomi Hagi, Kenneth F. Newcomer, Linda X. Jin, Suwanna Vangveravong, Brian A. Van Tine, William G. Hawkins, Dirk Spitzer
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)
Abstract Sigma-2-ligands (S2L) are characterized by high binding affinities to their cognate sigma-2 receptor, overexpressed in rapidly proliferating tumor cells. As such, S2L were developed as imaging probes (ISO1) or as cancer therapeutics, alone (
Externí odkaz:
https://doaj.org/article/ab445ff44b324f118dd5b3e9afc0d657
Autor:
Takaomi Hagi, Suwanna Vangveravong, Rony Takchi, Qingqing Gong, S. Peter Goedegebuure, Herve Tiriac, Brian A. Van Tine, Matthew A. Powell, William G. Hawkins, Dirk Spitzer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cancer selective apoptosis remains a therapeutic challenge and off-target toxicity has limited enthusiasm for this target clinically. Sigma-2 ligands (S2) have been shown to enhance the cancer selectivity of small molecule drug candidates by
Externí odkaz:
https://doaj.org/article/9e2904ef921e408c9a9dcba07e068c79
Autor:
Takaomi Hagi, Yukinori Kurokawa, Noboru Kobayashi, Tsuyoshi Takahashi, Takuro Saito, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Makoto Yamasaki, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Perioperative systemic inflammation induced by surgical stress elevates the risk of hematogenous cancer metastasis. This study investigated the anti-metastatic effects and mechanisms of methylprednisolone (MP) administration for surgical str
Externí odkaz:
https://doaj.org/article/721c71d72d4545deaa88e9e452b89840
Autor:
Takaomi Hagi, Yohei Hosoda, Izumi Komoto, Shinji Uemoto, Susumu Hijioka, Yoshiro Taki, Kazuhiro Nishiyama, Masayuki Imamura
Publikováno v:
Surgical Case Reports, Vol 3, Iss 1, Pp 1-6 (2017)
Abstract Background Primary hepatic gastrinoma causing severe ulcerogenic syndrome is extremely rare. Herein, we report a case of primary hepatic gastrinoma accompanied by hyperplasia of multi-nodular Brunner’s glands in a patient who instead, preo
Externí odkaz:
https://doaj.org/article/5a12382e4bcc4834b94dffb4799d3193
Autor:
Yuichiro Doki, Tomoki Makino, Kotaro Yamashita, Takaomi Hagi, Yukinori Kurokawa, Yuji Ishii, Takuro Saito, Koji Tanaka, Tsuyoshi Takahashi, Makoto Yamasaki, Hidetoshi Eguchi, Kiyokazu Nakajima
Publikováno v:
Surgery Today. 52:715-720
Microfocus computed tomography (micro-CT) has not been widely used at high radiation intensity (industrial micro-CT) in life science fields. In this preliminary study, we investigated its potential value in the detection of micro-hepatic tumors in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775abda01afc148ebd5662552b76ed4d
https://doi.org/10.1007/s00595-021-02396-1
https://doi.org/10.1007/s00595-021-02396-1
Autor:
Tomoki Makino, Takaomi Hagi, Masaaki Motoori, Yukinori Kurokawa, Koji Tanaka, Takuro Saito, Yuichiro Doki, Kiyokazu Nakajima, Kotaro Yamashita, Makoto Yamasaki, Hidetoshi Eguchi, Yutaka Kimura, Tsuyoshi Takahashi
Publikováno v:
Surgery Today. 51:777-784
To investigate the relationship between changes in taste due to surgical procedures and other clinical factors, we performed a detailed investigation of taste alteration in patients who underwent gastrectomy. Questionnaires on taste alteration were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b452b89c3f800c5beefd1b62751d94
https://doi.org/10.1007/s00595-020-02194-1
https://doi.org/10.1007/s00595-020-02194-1
Autor:
Makoto Yamasaki, Hidetoshi Eguchi, Taroh Satoh, Yukinori Kurokawa, Jin Matsuyama, Yusuke Akamaru, Motohiro Hirao, Takeshi Omori, Yuichiro Doki, Kazumasa Fujitani, Tsuyoshi Takahashi, Ryohei Kawabata, Takaomi Hagi
Publikováno v:
British Journal of Cancer
Background Predictive factors of nivolumab treatment response in patients with gastric cancer (GC) remain unclear. Methods In this retrospective cohort study, tissue specimens of patients with unresectable or recurrent GC and prior or scheduled treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2a046d505831fad178f6acd05bdb94
https://doi.org/10.1038/s41416-020-0975-7
https://doi.org/10.1038/s41416-020-0975-7
Autor:
Taroh Satoh, Daisuke Sakai, Takaomi Hagi, Yuichiro Doki, Masaaki Motoori, Makoto Yamasaki, Koji Tanaka, Masaki Mori, Naohiro Nishida, Tomoki Makino, Yutaka Kimura
Publikováno v:
Annals of Surgical Oncology. 26:4754-4764
Dysphagia is a major symptom of esophageal cancer (EC) that significantly affects patient quality of life; however, little is known regarding its clinical impact on the treatment course in patients with EC. This retrospective study included 434 conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c00d63ced16e0e533a7f6a6d6f1fa83
https://doi.org/10.1245/s10434-019-07744-7
https://doi.org/10.1245/s10434-019-07744-7
Autor:
Kiyokazu Nakajima, Tomoki Makino, Makoto Yamasaki, Masaki Mori, Yoshiki Taniguchi, Takaomi Hagi, Yuichiro Doki, Tsuyoshi Takahashi, Koji Tanaka, Yukinori Kurokawa, Yasuhiro Miyazaki
Publikováno v:
Annals of Surgical Oncology. 26:2831-2838
Surgery often introduce inflammatory response, which may promote tumor growth and metastasis of residual cancer cells. We investigated the impacts of methylprednisolone on the tumor growth and peritoneal seedings in mice treated with lipopolysacchari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef50121bfc06d96ed96fca8689bd79e6
https://doi.org/10.1245/s10434-019-07585-4
https://doi.org/10.1245/s10434-019-07585-4
Autor:
Kiyokazu Nakajima, Kotaro Yamashita, Eiichi Morii, Takaomi Hagi, Masaaki Motoori, Takuro Saito, Tsuyoshi Takahashi, Yutaka Kimura, Yukinori Kurokawa, Makoto Yamasaki, Hidetoshi Eguchi, Yuichiro Doki, Tomoki Makino, Koji Tanaka
Publikováno v:
Annals of surgery. 275(6)
OBJECTIVE To evaluate pathological response to NAC in metastatic LNs, and assess its clinical prognostic significance in patients with EC. SUMMARY OF BACKGROUND DATA The pathological response to preoperative treatment is commonly evaluated in the PT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad00fcc8c640f60e7d44892a28273b35
https://pubmed.ncbi.nlm.nih.gov/33214452
https://pubmed.ncbi.nlm.nih.gov/33214452