Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Takao Shoji"'
Autor:
Tomohiko Yamamura, Tomoko Horinouchi, Tomomi Adachi, Maki Terakawa, Yutaka Takaoka, Kohei Omachi, Minoru Takasato, Kiyosumi Takaishi, Takao Shoji, Yoshiyuki Onishi, Yoshito Kanazawa, Makoto Koizumi, Yasuko Tomono, Aki Sugano, Akemi Shono, Shogo Minamikawa, China Nagano, Nana Sakakibara, Shinya Ishiko, Yuya Aoto, Misato Kamura, Yutaka Harita, Kenichiro Miura, Shoichiro Kanda, Naoya Morisada, Rini Rossanti, Ming Juan Ye, Yoshimi Nozu, Masafumi Matsuo, Hirofumi Kai, Kazumoto Iijima, Kandai Nozu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Alport syndrome is a progressive inherited nephritis accompanied by sensorineural loss of hearing and ocular abnormalities, for which there is currently no effective therapy. Here, the authors develop an exon-skipping therapy using an antisense-oligo
Externí odkaz:
https://doaj.org/article/165df2dbd3f44073aaae13fc966489b5
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1946-1955 (2018)
Artificial orthogonal bond formations such as the alkyne–azide cycloaddition have enabled selective bioconjugations under mild conditions, yet naturally occurring linkages between native functional groups would be more straightforward to elaborate
Externí odkaz:
https://doaj.org/article/55c8cda6ea9c4bf287f86256befbb436
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2176
Antisense oligonucleotides (ASOs) are widely used for the identification of gene functions and regulation of genes involved in different diseases for therapeutic purposes. For in vitro evaluation of the knockdown activity of gapmer ASOs, we often use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a12b7128d0d686a7fe3eec34a645125
https://pubmed.ncbi.nlm.nih.gov/32865789
https://pubmed.ncbi.nlm.nih.gov/32865789
Autor:
Minoru Takasato, Shogo Minamikawa, Kazumoto Iijima, Nana Sakakibara, Tomoko Horinouchi, Tomohiko Yamamura, Yoshiyuki Onishi, Yoshito Kanazawa, Hirofumi Kai, Tomomi Adachi, Kohei Omachi, Ming Juan Ye, Kenichiro Miura, Maki Terakawa, Kiyosumi Takaishi, Takao Shoji, China Nagano, Masafumi Matsuo, Akemi Shono, Misato Kamura, Shoichiro Kanda, Yutaka Harita, Yutaka Takaoka, Naoya Morisada, Shinya Ishiko, Kandai Nozu, Aki Sugano, Yoshimi Nozu, Yuya Aoto, Rini Rossanti, Yasuko Tomono, Makoto Koizumi
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Currently, there are no treatments for Alport syndrome, which is the second most commonly inherited kidney disease. Here we report the development of an exon-skipping therapy using an antisense-oligonucleotide (ASO) for severe male X-linked Alport sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6c2dfb7226e7010d90166b17536923
http://europepmc.org/articles/PMC7265383
http://europepmc.org/articles/PMC7265383
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607701
Antisense oligonucleotides (ASOs) are widely used for the identification of gene functions and regulation of genes involved in different diseases for therapeutic purposes. For in vitro evaluation of the knockdown activity of gapmer ASOs, we often use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4c238483750e5264c7a5ad66fde465b
https://doi.org/10.1007/978-1-0716-0771-8_11
https://doi.org/10.1007/978-1-0716-0771-8_11
Publikováno v:
Chemistry – A European Journal. 24:17902-17905
Azanucleosides, the sugar-modified nucleoside analogues, have various biological activities, while their efficient synthetic strategy is still under development. Herein, a novel method for the synthesis of pharmaceutically relevant azanucleosides, β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9d3fd460f258a70492bb2b2d600943
https://doi.org/10.1002/chem.201804285
https://doi.org/10.1002/chem.201804285
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1946-1955 (2018)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
Artificial orthogonal bond formations such as the alkyne–azide cycloaddition have enabled selective bioconjugations under mild conditions, yet naturally occurring linkages between native functional groups would be more straightforward to elaborate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a25201625a1bcae9acb79ef4698947f
https://doi.org/10.3762/bjoc.14.169
https://doi.org/10.3762/bjoc.14.169
Publikováno v:
Angewandte Chemie International Edition. 56:4011-4014
Azanucleosides, in which the 4'-oxygen atom has been replaced with a nitrogen atom, have drawn much attention owing to their anticancer and antivirus activity, and tolerance towards nucleases. However, the traditional synthetic strategy requires mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a893809a635d676921aee3ea173a39
https://doi.org/10.1002/anie.201700547
https://doi.org/10.1002/anie.201700547
Publikováno v:
Electrochimica Acta. 200:290-295
A facile electrochemical method for modification of the 5-position in N -acryloyl-proline methyl ester ( N -Acr-Pro-OMe), followed by post-functionalization at the N -terminus by conjugate addition, was developed using anodic modification in a LiClO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dfa5cf3e21cb97b88183eb4b675c17b
https://doi.org/10.1016/j.electacta.2016.03.073
https://doi.org/10.1016/j.electacta.2016.03.073
Publikováno v:
Organic Letters. 18:800-803
A straightforward method for the synthesis of oligonucleotide blocks using a Cbz-type alkyl-chain-soluble support (Z-ACSS) attached to the 3'-OH group of 3'-terminal nucleosides was developed. The Z-ACSS allowed for the preparation of fully protected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9824776fd4103af071d4bf752e6c66
https://doi.org/10.1021/acs.orglett.6b00077
https://doi.org/10.1021/acs.orglett.6b00077